Multimorbidity is associated with fragility fractures in women 50 years and older: A nationwide cross-sectional study
Introduction: Multimorbidity is a worldwide health problem, especially in elderly patients who have a higher risk of fragility fracture. Currently, there is insufficient knowledge about the burden of multimorbidity in patients with previous fragility fracture. The aim of this study was to evaluate t...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Bone Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S235218722100396X |
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| author | Anabela Barcelos David G. Lopes Helena Canhão Jaime da Cunha Branco Ana Maria Rodrigues |
| author_facet | Anabela Barcelos David G. Lopes Helena Canhão Jaime da Cunha Branco Ana Maria Rodrigues |
| author_sort | Anabela Barcelos |
| collection | DOAJ |
| description | Introduction: Multimorbidity is a worldwide health problem, especially in elderly patients who have a higher risk of fragility fracture. Currently, there is insufficient knowledge about the burden of multimorbidity in patients with previous fragility fracture. The aim of this study was to evaluate the association between multimorbidity and previous fragility fracture, and to assess the effect of fragility fracture and/or multimorbidity in the perception of quality-of-life and physical function, in women 50 years of age and older. Methods: Women aged ≥50 years from the EpiReumaPt study (2011−2013), a nationwide population-based study, were evaluated. Self-reported data regarding sociodemographics, health-related quality of life, physical functioning, fragility fracture, and multimorbidity were collected using a semi-structured questionnaire. Multimorbidity was defined as 2 or more chronic non-communicable diseases. Descriptive exploratory analysis of the data was performed using hypothesis testing. Multiple logistic regression modelling was used to assess the association between multimorbidity and fragility fractures, and linear regression was used for the quality-of-life and physical function outcomes. Results: The estimated prevalence of fragility fracture in women older than 50 years was 17.5%. A higher prevalence of multimorbidity (74.6%) was found in the group of women with previous fragility fracture than in those without previous fragility fracture. Multivariate logistic regression analysis revealed that women with multimorbidity had a higher odds of fragility fracture (adjusted odds ratio, 1.38; 95% confidence interval, 1.12–1.69), compared with women with 1 or no self-reported non-communicable chronic diseases. In women with previous fragility fracture, rheumatic diseases (62.7%) and hypertension (58.6%) were the most frequently self-reported non-communicable chronic diseases. Both multimorbidity and a previous fragility fracture were independently associated with worse health-related quality of life and physical functioning. Conclusions: Women 50 years and older with multimorbidity had a significantly increased odds of fragility fracture. Fragility fracture and multimorbidity were negatively associated with quality of life and disability. This study emphasizes the need to redesign health services to care for patients to prevent non-communicable chronic diseases and fragility fracture, particularly in women 50 years and older, in whom these diseases are likely to potentiate the risk of fragility fracture. |
| first_indexed | 2024-12-17T20:52:18Z |
| format | Article |
| id | doaj.art-98ab5026bced4052a3d2bd762cb81cc6 |
| institution | Directory Open Access Journal |
| issn | 2352-1872 |
| language | English |
| last_indexed | 2024-12-17T20:52:18Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj.art-98ab5026bced4052a3d2bd762cb81cc62022-12-21T21:32:58ZengElsevierBone Reports2352-18722021-12-0115101139Multimorbidity is associated with fragility fractures in women 50 years and older: A nationwide cross-sectional studyAnabela Barcelos0David G. Lopes1Helena Canhão2Jaime da Cunha Branco3Ana Maria Rodrigues4NOVA National School of Public Health, Public Health Research Centre, Universidade NOVA de Lisboa, Lisboa, Portugal; Comprehensive Health Research Center (CHRC), Universidade NOVA de Lisboa, Lisboa, Portugal; EpiDoC Unit, CEDOC, NOVA Medical School, Universidade Nova de Lisboa, Lisboa, Portugal; Rheumatology Department, CHBV, Aveiro, Portugal; Corresponding author at: Rheumatology Department, Centro Hospitalar do Baixo Vouga, Hospital Infante D. Pedro, EPE, Rua Artur Ravara, 3814-501 Aveiro, Portugal.Comprehensive Health Research Center (CHRC), Universidade NOVA de Lisboa, Lisboa, Portugal; EpiDoC Unit, CEDOC, NOVA Medical School, Universidade Nova de Lisboa, Lisboa, PortugalNOVA National School of Public Health, Public Health Research Centre, Universidade NOVA de Lisboa, Lisboa, Portugal; Comprehensive Health Research Center (CHRC), Universidade NOVA de Lisboa, Lisboa, Portugal; EpiDoC Unit, CEDOC, NOVA Medical School, Universidade Nova de Lisboa, Lisboa, Portugal; Rheumatology Department, CHULC, Lisboa, PortugalComprehensive Health Research Center (CHRC), Universidade NOVA de Lisboa, Lisboa, Portugal; EpiDoC Unit, CEDOC, NOVA Medical School, Universidade Nova de Lisboa, Lisboa, Portugal; Rheumatology Department, CHLO, Lisboa, PortugalComprehensive Health Research Center (CHRC), Universidade NOVA de Lisboa, Lisboa, Portugal; EpiDoC Unit, CEDOC, NOVA Medical School, Universidade Nova de Lisboa, Lisboa, Portugal; Rheumatology Department, Hospital dos Lusíadas, Lisboa, PortugalIntroduction: Multimorbidity is a worldwide health problem, especially in elderly patients who have a higher risk of fragility fracture. Currently, there is insufficient knowledge about the burden of multimorbidity in patients with previous fragility fracture. The aim of this study was to evaluate the association between multimorbidity and previous fragility fracture, and to assess the effect of fragility fracture and/or multimorbidity in the perception of quality-of-life and physical function, in women 50 years of age and older. Methods: Women aged ≥50 years from the EpiReumaPt study (2011−2013), a nationwide population-based study, were evaluated. Self-reported data regarding sociodemographics, health-related quality of life, physical functioning, fragility fracture, and multimorbidity were collected using a semi-structured questionnaire. Multimorbidity was defined as 2 or more chronic non-communicable diseases. Descriptive exploratory analysis of the data was performed using hypothesis testing. Multiple logistic regression modelling was used to assess the association between multimorbidity and fragility fractures, and linear regression was used for the quality-of-life and physical function outcomes. Results: The estimated prevalence of fragility fracture in women older than 50 years was 17.5%. A higher prevalence of multimorbidity (74.6%) was found in the group of women with previous fragility fracture than in those without previous fragility fracture. Multivariate logistic regression analysis revealed that women with multimorbidity had a higher odds of fragility fracture (adjusted odds ratio, 1.38; 95% confidence interval, 1.12–1.69), compared with women with 1 or no self-reported non-communicable chronic diseases. In women with previous fragility fracture, rheumatic diseases (62.7%) and hypertension (58.6%) were the most frequently self-reported non-communicable chronic diseases. Both multimorbidity and a previous fragility fracture were independently associated with worse health-related quality of life and physical functioning. Conclusions: Women 50 years and older with multimorbidity had a significantly increased odds of fragility fracture. Fragility fracture and multimorbidity were negatively associated with quality of life and disability. This study emphasizes the need to redesign health services to care for patients to prevent non-communicable chronic diseases and fragility fracture, particularly in women 50 years and older, in whom these diseases are likely to potentiate the risk of fragility fracture.http://www.sciencedirect.com/science/article/pii/S235218722100396XFragility fracturesOsteoporosisMultimorbidityWomen |
| spellingShingle | Anabela Barcelos David G. Lopes Helena Canhão Jaime da Cunha Branco Ana Maria Rodrigues Multimorbidity is associated with fragility fractures in women 50 years and older: A nationwide cross-sectional study Bone Reports Fragility fractures Osteoporosis Multimorbidity Women |
| title | Multimorbidity is associated with fragility fractures in women 50 years and older: A nationwide cross-sectional study |
| title_full | Multimorbidity is associated with fragility fractures in women 50 years and older: A nationwide cross-sectional study |
| title_fullStr | Multimorbidity is associated with fragility fractures in women 50 years and older: A nationwide cross-sectional study |
| title_full_unstemmed | Multimorbidity is associated with fragility fractures in women 50 years and older: A nationwide cross-sectional study |
| title_short | Multimorbidity is associated with fragility fractures in women 50 years and older: A nationwide cross-sectional study |
| title_sort | multimorbidity is associated with fragility fractures in women 50 years and older a nationwide cross sectional study |
| topic | Fragility fractures Osteoporosis Multimorbidity Women |
| url | http://www.sciencedirect.com/science/article/pii/S235218722100396X |
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