Attempts and outcomes of liquisolid technology: An updated chronological compilation of innovative ideas and adjuvants in the field
It has been observed that most of the chemical entities have high lipophilicity and poor aqueous solubility, which result in poor bioavailability. In order to improve the bioavailability, the release behavior of such drugs should be improved. Although there are numerous techniques to handle solubili...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2016-01-01
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| Series: | Pharmaceutical and Biomedical Research |
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| Online Access: | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-63-4&slc_lang=en&sid=1 |
| _version_ | 1818291768843567104 |
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| author | Vijay Sharma Kamla Pathak |
| author_facet | Vijay Sharma Kamla Pathak |
| author_sort | Vijay Sharma |
| collection | DOAJ |
| description | It has been observed that most of the chemical entities have high lipophilicity and poor aqueous solubility, which result in poor bioavailability. In order to improve the bioavailability, the release behavior of such drugs should be improved. Although there are numerous techniques to handle solubility related issue, but they are expensive due to involvement of complicated equipments, advanced manufacturing operations that includes multiple and tedious steps. The liquisolid technology or powder solution technology is a promising technique for modifying the release characteristics of active pharmaceutical ingredients. As the liquisolid technology uses similar production processes as followed to develop a conventional tablet, but this technology to improve the release rate of poorly water soluble drugs is simple and cost effective The core concept of the technique involves, liquids such as solution/dispersion of poorly soluble drugs in a non-volatile solvent that is transformed into free flowing and desirable compression characteristics. To develop a fast-release liquisolid formulation, high amount of liquid vehicle is required while more effective tableting excipients with high liquid adsorption are needed to reduce the weight of the tablet. Simultaneously, this technology also has the capability to sustain the drug release and allow the development of sustained release formulation with desirable release kinetics. The present work deals with the chronological compilation and briefing of all the reported researches which involved the concept of underlined technology by the use of common as well as novel excipients to modify the release behavior of therapeutically active compounds. |
| first_indexed | 2024-12-13T02:49:19Z |
| format | Article |
| id | doaj.art-98adb693140149a6a6c1ee800f5a1f0c |
| institution | Directory Open Access Journal |
| issn | 2423-4486 2423-4494 |
| language | English |
| last_indexed | 2024-12-13T02:49:19Z |
| publishDate | 2016-01-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-98adb693140149a6a6c1ee800f5a1f0c2022-12-22T00:02:06ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44862423-44942016-01-0124121Attempts and outcomes of liquisolid technology: An updated chronological compilation of innovative ideas and adjuvants in the fieldVijay Sharma0Kamla Pathak1 Department of Pharmaceutics, Rajiv Academy for Pharmacy, N.H. #2, Delhi – Mathura Road, P.O. Chattikara, Mathura, Uttar Pradesh – 281001, India Department of Pharmaceutics, Pharmacy College Saifai, UPRIMS&R, Saifai, Etawah, Uttar Pradesh, India It has been observed that most of the chemical entities have high lipophilicity and poor aqueous solubility, which result in poor bioavailability. In order to improve the bioavailability, the release behavior of such drugs should be improved. Although there are numerous techniques to handle solubility related issue, but they are expensive due to involvement of complicated equipments, advanced manufacturing operations that includes multiple and tedious steps. The liquisolid technology or powder solution technology is a promising technique for modifying the release characteristics of active pharmaceutical ingredients. As the liquisolid technology uses similar production processes as followed to develop a conventional tablet, but this technology to improve the release rate of poorly water soluble drugs is simple and cost effective The core concept of the technique involves, liquids such as solution/dispersion of poorly soluble drugs in a non-volatile solvent that is transformed into free flowing and desirable compression characteristics. To develop a fast-release liquisolid formulation, high amount of liquid vehicle is required while more effective tableting excipients with high liquid adsorption are needed to reduce the weight of the tablet. Simultaneously, this technology also has the capability to sustain the drug release and allow the development of sustained release formulation with desirable release kinetics. The present work deals with the chronological compilation and briefing of all the reported researches which involved the concept of underlined technology by the use of common as well as novel excipients to modify the release behavior of therapeutically active compounds.http://pbr.mazums.ac.ir/browse.php?a_code=A-10-63-4&slc_lang=en&sid=1Liquisolid technology non-volatile solvent carrier material coating material dissolution enhancement liquisolid compact sustained release |
| spellingShingle | Vijay Sharma Kamla Pathak Attempts and outcomes of liquisolid technology: An updated chronological compilation of innovative ideas and adjuvants in the field Pharmaceutical and Biomedical Research Liquisolid technology non-volatile solvent carrier material coating material dissolution enhancement liquisolid compact sustained release |
| title | Attempts and outcomes of liquisolid technology: An updated chronological compilation of innovative ideas and adjuvants in the field |
| title_full | Attempts and outcomes of liquisolid technology: An updated chronological compilation of innovative ideas and adjuvants in the field |
| title_fullStr | Attempts and outcomes of liquisolid technology: An updated chronological compilation of innovative ideas and adjuvants in the field |
| title_full_unstemmed | Attempts and outcomes of liquisolid technology: An updated chronological compilation of innovative ideas and adjuvants in the field |
| title_short | Attempts and outcomes of liquisolid technology: An updated chronological compilation of innovative ideas and adjuvants in the field |
| title_sort | attempts and outcomes of liquisolid technology an updated chronological compilation of innovative ideas and adjuvants in the field |
| topic | Liquisolid technology non-volatile solvent carrier material coating material dissolution enhancement liquisolid compact sustained release |
| url | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-63-4&slc_lang=en&sid=1 |
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