Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite Envenomations
Snakebite envenomations (SBEs) are a neglected medical condition of global importance that mainly affect the tropical and subtropical regions. Clinical manifestations include pain, edema, hemorrhage, tissue necrosis, and neurotoxic signs, and may evolve to functional loss of the affected limb, acute...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.842576/full |
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| author | Asenate A. X. Adrião Aline O. dos Santos Emilly J. S. P. de Lima Jéssica B. Maciel Weider H. P. Paz Felipe M. A. da Silva Felipe M. A. da Silva Manuela B. Pucca Ana M. Moura-da-Silva Ana M. Moura-da-Silva Wuelton M. Monteiro Marco A. Sartim Marco A. Sartim Marco A. Sartim Hector H. F. Koolen Hector H. F. Koolen Hector H. F. Koolen |
| author_facet | Asenate A. X. Adrião Aline O. dos Santos Emilly J. S. P. de Lima Jéssica B. Maciel Weider H. P. Paz Felipe M. A. da Silva Felipe M. A. da Silva Manuela B. Pucca Ana M. Moura-da-Silva Ana M. Moura-da-Silva Wuelton M. Monteiro Marco A. Sartim Marco A. Sartim Marco A. Sartim Hector H. F. Koolen Hector H. F. Koolen Hector H. F. Koolen |
| author_sort | Asenate A. X. Adrião |
| collection | DOAJ |
| description | Snakebite envenomations (SBEs) are a neglected medical condition of global importance that mainly affect the tropical and subtropical regions. Clinical manifestations include pain, edema, hemorrhage, tissue necrosis, and neurotoxic signs, and may evolve to functional loss of the affected limb, acute renal and/or respiratory failure, and even death. The standard treatment for snake envenomations is antivenom, which is produced from the hyperimmunization of animals with snake toxins. The inhibition of the effects of SBEs using natural or synthetic compounds has been suggested as a complementary treatment particularly before admission to hospital for antivenom treatment, since these alternative molecules are also able to inhibit toxins. Biodiversity-derived molecules, namely those extracted from medicinal plants, are promising sources of toxin inhibitors that can minimize the deleterious consequences of SBEs. In this review, we systematically synthesize the literature on plant metabolites that can be used as toxin-inhibiting agents, as well as present the potential mechanisms of action of molecules derived from natural sources. These findings aim to further our understanding of the potential of natural products and provide new lead compounds as auxiliary therapies for SBEs. |
| first_indexed | 2024-12-12T02:39:02Z |
| format | Article |
| id | doaj.art-98afe7877e8a409fbe9879430b7b9b70 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T02:39:02Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj.art-98afe7877e8a409fbe9879430b7b9b702022-12-22T00:41:12ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-05-011310.3389/fimmu.2022.842576842576Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite EnvenomationsAsenate A. X. Adrião0Aline O. dos Santos1Emilly J. S. P. de Lima2Jéssica B. Maciel3Weider H. P. Paz4Felipe M. A. da Silva5Felipe M. A. da Silva6Manuela B. Pucca7Ana M. Moura-da-Silva8Ana M. Moura-da-Silva9Wuelton M. Monteiro10Marco A. Sartim11Marco A. Sartim12Marco A. Sartim13Hector H. F. Koolen14Hector H. F. Koolen15Hector H. F. Koolen16Post Graduate Program in Biodiversity and Biotechnology BIONORTE, Superior School of Health Sciences, Amazonas State University, Manaus, BrazilPost Graduate Program in Biodiversity and Biotechnology BIONORTE, Superior School of Health Sciences, Amazonas State University, Manaus, BrazilPost Graduate Program in Biodiversity and Biotechnology BIONORTE, Superior School of Health Sciences, Amazonas State University, Manaus, BrazilPost Graduate Program in Tropical Medicine, Department of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, BrazilPost Graduate Program in Chemistry, Department of Chemistry, Federal University of Amazonas, Manaus, BrazilPost Graduate Program in Chemistry, Department of Chemistry, Federal University of Amazonas, Manaus, BrazilMultidisciplinary Support Center, Federal University of Amazonas, Manaus, BrazilMedical School, Federal University of Roraima, Boa Vista, BrazilPost Graduate Program in Tropical Medicine, Department of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, BrazilLaboratory of Immunopathology, Institute Butantan, São Paulo, BrazilPost Graduate Program in Tropical Medicine, Department of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, BrazilPost Graduate Program in Biodiversity and Biotechnology BIONORTE, Superior School of Health Sciences, Amazonas State University, Manaus, BrazilPost Graduate Program in Tropical Medicine, Department of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, BrazilUniversity Nilton Lins, Manaus, BrazilPost Graduate Program in Biodiversity and Biotechnology BIONORTE, Superior School of Health Sciences, Amazonas State University, Manaus, BrazilPost Graduate Program in Tropical Medicine, Department of Teaching and Research, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, BrazilPost Graduate Program in Chemistry, Department of Chemistry, Federal University of Amazonas, Manaus, BrazilSnakebite envenomations (SBEs) are a neglected medical condition of global importance that mainly affect the tropical and subtropical regions. Clinical manifestations include pain, edema, hemorrhage, tissue necrosis, and neurotoxic signs, and may evolve to functional loss of the affected limb, acute renal and/or respiratory failure, and even death. The standard treatment for snake envenomations is antivenom, which is produced from the hyperimmunization of animals with snake toxins. The inhibition of the effects of SBEs using natural or synthetic compounds has been suggested as a complementary treatment particularly before admission to hospital for antivenom treatment, since these alternative molecules are also able to inhibit toxins. Biodiversity-derived molecules, namely those extracted from medicinal plants, are promising sources of toxin inhibitors that can minimize the deleterious consequences of SBEs. In this review, we systematically synthesize the literature on plant metabolites that can be used as toxin-inhibiting agents, as well as present the potential mechanisms of action of molecules derived from natural sources. These findings aim to further our understanding of the potential of natural products and provide new lead compounds as auxiliary therapies for SBEs.https://www.frontiersin.org/articles/10.3389/fimmu.2022.842576/fullbioactive compoundsplantsenvenomationsnakessnakebites |
| spellingShingle | Asenate A. X. Adrião Aline O. dos Santos Emilly J. S. P. de Lima Jéssica B. Maciel Weider H. P. Paz Felipe M. A. da Silva Felipe M. A. da Silva Manuela B. Pucca Ana M. Moura-da-Silva Ana M. Moura-da-Silva Wuelton M. Monteiro Marco A. Sartim Marco A. Sartim Marco A. Sartim Hector H. F. Koolen Hector H. F. Koolen Hector H. F. Koolen Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite Envenomations Frontiers in Immunology bioactive compounds plants envenomation snakes snakebites |
| title | Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite Envenomations |
| title_full | Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite Envenomations |
| title_fullStr | Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite Envenomations |
| title_full_unstemmed | Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite Envenomations |
| title_short | Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite Envenomations |
| title_sort | plant derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations |
| topic | bioactive compounds plants envenomation snakes snakebites |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.842576/full |
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