Legionnaires’ Disease Outbreak in Murcia, Spain

An explosive outbreak of Legionnaires’ disease occurred in Murcia, Spain, in July 2001. More than 800 suspected cases were reported; 449 of these cases were confirmed, which made this the world’s largest outbreak of the disease reported to date. Dates of onset for confirmed cases ranged from June 26...

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Main Authors: Ana García-Fulgueiras, Carmen Navarro, Daniel Fenoll, José García, Paulino González-Diego, Teresa Jiménez-Buñuales, Miguel Rodriguez, Rosa Lopez, Francisco Pacheco, Joaquín Ruiz, Manuel Segovia, Beatriz Baladrón, Carmen Pelaz
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2003-08-01
Series:Emerging Infectious Diseases
Subjects:
Online Access:https://wwwnc.cdc.gov/eid/article/9/8/03-0337_article
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author Ana García-Fulgueiras
Carmen Navarro
Daniel Fenoll
José García
Paulino González-Diego
Teresa Jiménez-Buñuales
Miguel Rodriguez
Rosa Lopez
Francisco Pacheco
Joaquín Ruiz
Manuel Segovia
Beatriz Baladrón
Carmen Pelaz
author_facet Ana García-Fulgueiras
Carmen Navarro
Daniel Fenoll
José García
Paulino González-Diego
Teresa Jiménez-Buñuales
Miguel Rodriguez
Rosa Lopez
Francisco Pacheco
Joaquín Ruiz
Manuel Segovia
Beatriz Baladrón
Carmen Pelaz
author_sort Ana García-Fulgueiras
collection DOAJ
description An explosive outbreak of Legionnaires’ disease occurred in Murcia, Spain, in July 2001. More than 800 suspected cases were reported; 449 of these cases were confirmed, which made this the world’s largest outbreak of the disease reported to date. Dates of onset for confirmed cases ranged from June 26 to July 19 , with a case-fatality rate of 1%. The epidemic curve and geographic pattern from the 600 completed epidemiologic questionnaires indicated an outdoor point-source exposure in the northern part of the city. A case-control study matching 85 patients living outside the city of Murcia with two controls each was undertaken to identify the outbreak source; the epidemiologic investigation implicated the cooling towers at a city hospital. An environmental isolate from these towers with an identical molecular pattern as the clinical isolates was subsequently identified and supported that epidemiologic conclusion.
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spelling doaj.art-98b376329e064391866dba6963e2e8262022-12-22T02:49:29ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592003-08-019891592110.3201/eid0908.030337Legionnaires’ Disease Outbreak in Murcia, SpainAna García-FulgueirasCarmen NavarroDaniel FenollJosé GarcíaPaulino González-DiegoTeresa Jiménez-BuñualesMiguel RodriguezRosa LopezFrancisco PachecoJoaquín RuizManuel SegoviaBeatriz BaladrónCarmen PelazAn explosive outbreak of Legionnaires’ disease occurred in Murcia, Spain, in July 2001. More than 800 suspected cases were reported; 449 of these cases were confirmed, which made this the world’s largest outbreak of the disease reported to date. Dates of onset for confirmed cases ranged from June 26 to July 19 , with a case-fatality rate of 1%. The epidemic curve and geographic pattern from the 600 completed epidemiologic questionnaires indicated an outdoor point-source exposure in the northern part of the city. A case-control study matching 85 patients living outside the city of Murcia with two controls each was undertaken to identify the outbreak source; the epidemiologic investigation implicated the cooling towers at a city hospital. An environmental isolate from these towers with an identical molecular pattern as the clinical isolates was subsequently identified and supported that epidemiologic conclusion.https://wwwnc.cdc.gov/eid/article/9/8/03-0337_articlecase-control studycommunity outbreakenvironmental exposureLegionnaires’ diseaseSpain
spellingShingle Ana García-Fulgueiras
Carmen Navarro
Daniel Fenoll
José García
Paulino González-Diego
Teresa Jiménez-Buñuales
Miguel Rodriguez
Rosa Lopez
Francisco Pacheco
Joaquín Ruiz
Manuel Segovia
Beatriz Baladrón
Carmen Pelaz
Legionnaires’ Disease Outbreak in Murcia, Spain
Emerging Infectious Diseases
case-control study
community outbreak
environmental exposure
Legionnaires’ disease
Spain
title Legionnaires’ Disease Outbreak in Murcia, Spain
title_full Legionnaires’ Disease Outbreak in Murcia, Spain
title_fullStr Legionnaires’ Disease Outbreak in Murcia, Spain
title_full_unstemmed Legionnaires’ Disease Outbreak in Murcia, Spain
title_short Legionnaires’ Disease Outbreak in Murcia, Spain
title_sort legionnaires disease outbreak in murcia spain
topic case-control study
community outbreak
environmental exposure
Legionnaires’ disease
Spain
url https://wwwnc.cdc.gov/eid/article/9/8/03-0337_article
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