iPSCs in Modeling and Therapy of Osteoarthritis
Osteoarthritis (OA) belongs to chronic degenerative disorders and is often a leading cause of disability in elderly patients. Typically, OA is manifested by articular cartilage erosion, pain, stiffness, and crepitus. Currently, the treatment options are limited, relying mostly on pharmacological the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-02-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/2/186 |
| _version_ | 1827589442417721344 |
|---|---|
| author | Maria Csobonyeiova Stefan Polak Andreas Nicodemou Radoslav Zamborsky Lubos Danisovic |
| author_facet | Maria Csobonyeiova Stefan Polak Andreas Nicodemou Radoslav Zamborsky Lubos Danisovic |
| author_sort | Maria Csobonyeiova |
| collection | DOAJ |
| description | Osteoarthritis (OA) belongs to chronic degenerative disorders and is often a leading cause of disability in elderly patients. Typically, OA is manifested by articular cartilage erosion, pain, stiffness, and crepitus. Currently, the treatment options are limited, relying mostly on pharmacological therapy, which is often related to numerous complications. The proper management of the disease is challenging because of the poor regenerative capacity of articular cartilage. During the last decade, cell-based approaches such as implantation of autologous chondrocytes or mesenchymal stem cells (MSCs) have shown promising results. However, the mentioned techniques face their hurdles (cell harvesting, low proliferation capacity). The invention of induced pluripotent stem cells (iPSCs) has created new opportunities to increase the efficacy of the cartilage healing process. iPSCs may represent an unlimited source of chondrocytes derived from a patient’s somatic cells, circumventing ethical and immunological issues. Aside from the regenerative potential of iPSCs, stem cell-derived cartilage tissue models could be a useful tool for studying the pathological process of OA. In our recent article, we reviewed the progress in chondrocyte differentiation techniques, disease modeling, and the current status of iPSC-based regenerative therapy of OA. |
| first_indexed | 2024-03-09T00:56:45Z |
| format | Article |
| id | doaj.art-98b5598d0d174a188caf5ca33d5d94b8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T00:56:45Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-98b5598d0d174a188caf5ca33d5d94b82023-12-11T16:51:12ZengMDPI AGBiomedicines2227-90592021-02-019218610.3390/biomedicines9020186iPSCs in Modeling and Therapy of OsteoarthritisMaria Csobonyeiova0Stefan Polak1Andreas Nicodemou2Radoslav Zamborsky3Lubos Danisovic4Institute of Histology and Embryology, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, SlovakiaInstitute of Histology and Embryology, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, SlovakiaInstitute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, SlovakiaNational Institute of Children’s Diseases, Department of Orthopedics, Faculty of Medicine, Comenius University, Limbova 1, 833 40 Bratislava, SlovakiaInstitute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, SlovakiaOsteoarthritis (OA) belongs to chronic degenerative disorders and is often a leading cause of disability in elderly patients. Typically, OA is manifested by articular cartilage erosion, pain, stiffness, and crepitus. Currently, the treatment options are limited, relying mostly on pharmacological therapy, which is often related to numerous complications. The proper management of the disease is challenging because of the poor regenerative capacity of articular cartilage. During the last decade, cell-based approaches such as implantation of autologous chondrocytes or mesenchymal stem cells (MSCs) have shown promising results. However, the mentioned techniques face their hurdles (cell harvesting, low proliferation capacity). The invention of induced pluripotent stem cells (iPSCs) has created new opportunities to increase the efficacy of the cartilage healing process. iPSCs may represent an unlimited source of chondrocytes derived from a patient’s somatic cells, circumventing ethical and immunological issues. Aside from the regenerative potential of iPSCs, stem cell-derived cartilage tissue models could be a useful tool for studying the pathological process of OA. In our recent article, we reviewed the progress in chondrocyte differentiation techniques, disease modeling, and the current status of iPSC-based regenerative therapy of OA.https://www.mdpi.com/2227-9059/9/2/186osteoarthritisiPSCsarticular cartilagestem cell-based therapydisease modeling |
| spellingShingle | Maria Csobonyeiova Stefan Polak Andreas Nicodemou Radoslav Zamborsky Lubos Danisovic iPSCs in Modeling and Therapy of Osteoarthritis Biomedicines osteoarthritis iPSCs articular cartilage stem cell-based therapy disease modeling |
| title | iPSCs in Modeling and Therapy of Osteoarthritis |
| title_full | iPSCs in Modeling and Therapy of Osteoarthritis |
| title_fullStr | iPSCs in Modeling and Therapy of Osteoarthritis |
| title_full_unstemmed | iPSCs in Modeling and Therapy of Osteoarthritis |
| title_short | iPSCs in Modeling and Therapy of Osteoarthritis |
| title_sort | ipscs in modeling and therapy of osteoarthritis |
| topic | osteoarthritis iPSCs articular cartilage stem cell-based therapy disease modeling |
| url | https://www.mdpi.com/2227-9059/9/2/186 |
| work_keys_str_mv | AT mariacsobonyeiova ipscsinmodelingandtherapyofosteoarthritis AT stefanpolak ipscsinmodelingandtherapyofosteoarthritis AT andreasnicodemou ipscsinmodelingandtherapyofosteoarthritis AT radoslavzamborsky ipscsinmodelingandtherapyofosteoarthritis AT lubosdanisovic ipscsinmodelingandtherapyofosteoarthritis |