Continuous Theta Burst Stimulation to the Secondary Visual Cortex at 80% Active Motor Threshold Does Not Impair Central Vision in Humans During a Simple Detection Task
Continuous theta burst stimulation (cTBS) is a powerful form of repetitive transcranial magnetic stimulation capable of suppressing cortical excitability for up to 50 min. A growing number of studies have applied cTBS to the visual cortex in human subjects to investigate the neural dynamics of visua...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2021.709275/full |
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| author | Carly A. Lasagna Stephan F. Taylor Taraz G. Lee Saige Rutherford Saige Rutherford Tristan Greathouse Pan Gu Ivy F. Tso Ivy F. Tso |
| author_facet | Carly A. Lasagna Stephan F. Taylor Taraz G. Lee Saige Rutherford Saige Rutherford Tristan Greathouse Pan Gu Ivy F. Tso Ivy F. Tso |
| author_sort | Carly A. Lasagna |
| collection | DOAJ |
| description | Continuous theta burst stimulation (cTBS) is a powerful form of repetitive transcranial magnetic stimulation capable of suppressing cortical excitability for up to 50 min. A growing number of studies have applied cTBS to the visual cortex in human subjects to investigate the neural dynamics of visual processing, but few have specifically examined its effects on central vision, which has crucial implications for safety and inference on downstream cognitive effects. The present study assessed the safety of offline, neuronavigated cTBS to V2 by examining its effects on central vision performance. In this single-blind, randomized sham-controlled, crossover study, 17 healthy adults received cTBS (at 80% active motor threshold) and sham to V2 1–2 weeks apart. Their central vision (≤8°) was tested at 1-min (T1) and again at 50-min (T50) post-stimulation. Effects of condition (cTBS vs. sham) and time (T1 vs. T50) on accuracy and reaction time were examined using Bayes factor. Bayes factor results suggested that cTBS did not impair stimulus detection over the entire central visual field nor subfields at T1 or T50. Our results offer the first explicit evidence supporting that cTBS applied to V2 does not create blind spots in the central visual field in humans during a simple detection task. Any subtler changes to vision and downstream visual perception should be investigated in future studies. |
| first_indexed | 2024-12-16T08:52:16Z |
| format | Article |
| id | doaj.art-98b579b84dae4db28f5c8b2f3739717b |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-16T08:52:16Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-98b579b84dae4db28f5c8b2f3739717b2022-12-21T22:37:22ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612021-08-011510.3389/fnhum.2021.709275709275Continuous Theta Burst Stimulation to the Secondary Visual Cortex at 80% Active Motor Threshold Does Not Impair Central Vision in Humans During a Simple Detection TaskCarly A. Lasagna0Stephan F. Taylor1Taraz G. Lee2Saige Rutherford3Saige Rutherford4Tristan Greathouse5Pan Gu6Ivy F. Tso7Ivy F. Tso8Department of Psychiatry, University of Michigan, Ann Arbor, MI, United StatesDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, United StatesDepartment of Psychology, University of Michigan, Ann Arbor, MI, United StatesDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, United StatesDepartment of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, NetherlandsDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, United StatesDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, United StatesDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, United StatesDepartment of Psychology, University of Michigan, Ann Arbor, MI, United StatesContinuous theta burst stimulation (cTBS) is a powerful form of repetitive transcranial magnetic stimulation capable of suppressing cortical excitability for up to 50 min. A growing number of studies have applied cTBS to the visual cortex in human subjects to investigate the neural dynamics of visual processing, but few have specifically examined its effects on central vision, which has crucial implications for safety and inference on downstream cognitive effects. The present study assessed the safety of offline, neuronavigated cTBS to V2 by examining its effects on central vision performance. In this single-blind, randomized sham-controlled, crossover study, 17 healthy adults received cTBS (at 80% active motor threshold) and sham to V2 1–2 weeks apart. Their central vision (≤8°) was tested at 1-min (T1) and again at 50-min (T50) post-stimulation. Effects of condition (cTBS vs. sham) and time (T1 vs. T50) on accuracy and reaction time were examined using Bayes factor. Bayes factor results suggested that cTBS did not impair stimulus detection over the entire central visual field nor subfields at T1 or T50. Our results offer the first explicit evidence supporting that cTBS applied to V2 does not create blind spots in the central visual field in humans during a simple detection task. Any subtler changes to vision and downstream visual perception should be investigated in future studies.https://www.frontiersin.org/articles/10.3389/fnhum.2021.709275/fulltranscranial magnetic stimulationtheta burst stimulationvisionsafetyV2visual cortex |
| spellingShingle | Carly A. Lasagna Stephan F. Taylor Taraz G. Lee Saige Rutherford Saige Rutherford Tristan Greathouse Pan Gu Ivy F. Tso Ivy F. Tso Continuous Theta Burst Stimulation to the Secondary Visual Cortex at 80% Active Motor Threshold Does Not Impair Central Vision in Humans During a Simple Detection Task Frontiers in Human Neuroscience transcranial magnetic stimulation theta burst stimulation vision safety V2 visual cortex |
| title | Continuous Theta Burst Stimulation to the Secondary Visual Cortex at 80% Active Motor Threshold Does Not Impair Central Vision in Humans During a Simple Detection Task |
| title_full | Continuous Theta Burst Stimulation to the Secondary Visual Cortex at 80% Active Motor Threshold Does Not Impair Central Vision in Humans During a Simple Detection Task |
| title_fullStr | Continuous Theta Burst Stimulation to the Secondary Visual Cortex at 80% Active Motor Threshold Does Not Impair Central Vision in Humans During a Simple Detection Task |
| title_full_unstemmed | Continuous Theta Burst Stimulation to the Secondary Visual Cortex at 80% Active Motor Threshold Does Not Impair Central Vision in Humans During a Simple Detection Task |
| title_short | Continuous Theta Burst Stimulation to the Secondary Visual Cortex at 80% Active Motor Threshold Does Not Impair Central Vision in Humans During a Simple Detection Task |
| title_sort | continuous theta burst stimulation to the secondary visual cortex at 80 active motor threshold does not impair central vision in humans during a simple detection task |
| topic | transcranial magnetic stimulation theta burst stimulation vision safety V2 visual cortex |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2021.709275/full |
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