THE IMPACT OF GUT MICROBIOTA ON RECURRENT APHTHOUS STOMATITIS
Recurrent Aphthous Stomatitis (RAS) is a prevalent oral mucosal disorder characterized by recurring painful ulcers. The pathogenesis of RAS remains incompletely understood, but emerging evidence suggests a significant link between gut microbiota and the development of RAS. This review aims to explor...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Romanian Dental Association for Education
2024-02-01
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| Series: | Romanian Journal of Medical and Dental Education |
| Subjects: | |
| Online Access: | https://journal.adre.ro/the-impact-of-gut-microbiota-on-recurrent-aphthous-stomatitis/ |
| _version_ | 1797205854887346176 |
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| author | Mihaela Paula Toader Oana Mihaela Condurache Hritcu Cristina Popa Ana Maria Sciuca Bianca Andreea Onofrei Stefan Vasile Toader |
| author_facet | Mihaela Paula Toader Oana Mihaela Condurache Hritcu Cristina Popa Ana Maria Sciuca Bianca Andreea Onofrei Stefan Vasile Toader |
| author_sort | Mihaela Paula Toader |
| collection | DOAJ |
| description | Recurrent Aphthous Stomatitis (RAS) is a prevalent oral mucosal disorder characterized by recurring painful ulcers. The pathogenesis of RAS remains incompletely understood, but emerging evidence suggests a significant link between gut microbiota and the development of RAS. This review aims to explore the existing literature on the interplay between gut microbiota and RAS, focusing on how intestinal dysbiosis may influence the onset and severity of RAS. We discuss the role of gut microbiota in immune modulation, the breakdown of oral tolerance, and the possible pathways through which gut bacteria can affect oral health. Additionally, we examine the impact of diet, antibiotics, and probiotics on the gut microbiota and, subsequently, on RAS. The review concludes with potential therapeutic strategies targeting gut microbiota to manage and prevent RAS, paving the way for novel interventions in this field. |
| first_indexed | 2024-04-24T08:57:45Z |
| format | Article |
| id | doaj.art-98b7621d678f40df9485d78807fae66f |
| institution | Directory Open Access Journal |
| issn | 2393-1531 2393-1108 |
| language | English |
| last_indexed | 2024-04-24T08:57:45Z |
| publishDate | 2024-02-01 |
| publisher | Romanian Dental Association for Education |
| record_format | Article |
| series | Romanian Journal of Medical and Dental Education |
| spelling | doaj.art-98b7621d678f40df9485d78807fae66f2024-04-16T06:33:25ZengRomanian Dental Association for EducationRomanian Journal of Medical and Dental Education2393-15312393-11082024-02-011318993THE IMPACT OF GUT MICROBIOTA ON RECURRENT APHTHOUS STOMATITISMihaela Paula Toader0Oana Mihaela Condurache Hritcu1Cristina Popa2Ana Maria Sciuca3Bianca Andreea Onofrei4Stefan Vasile Toader5Discipline of Oral Medicine, Oral Dermatology, Faculty of Dental Medicine, Grigore T. Popa University of Medicine and PharmacyDiscipline of Oral Medicine, Oral Dermatology, Faculty of Dental Medicine, Grigore T. Popa University of Medicine and PharmacyDiscipline of Oral Medicine, Oral Dermatology, Faculty of Dental Medicine, Grigore T. Popa University of Medicine and PharmacyDiscipline of Oral Medicine, Oral Dermatology, Faculty of Dental Medicine, Grigore T. Popa University of Medicine and PharmacyDiscipline of Oral Medicine, Oral Dermatology, Faculty of Dental Medicine, Grigore T. Popa University of Medicine and PharmacyDiscipline of Physiopathology, Faculty of Dental Medicine, Grigore T. Popa University of Medicine and PharmacyRecurrent Aphthous Stomatitis (RAS) is a prevalent oral mucosal disorder characterized by recurring painful ulcers. The pathogenesis of RAS remains incompletely understood, but emerging evidence suggests a significant link between gut microbiota and the development of RAS. This review aims to explore the existing literature on the interplay between gut microbiota and RAS, focusing on how intestinal dysbiosis may influence the onset and severity of RAS. We discuss the role of gut microbiota in immune modulation, the breakdown of oral tolerance, and the possible pathways through which gut bacteria can affect oral health. Additionally, we examine the impact of diet, antibiotics, and probiotics on the gut microbiota and, subsequently, on RAS. The review concludes with potential therapeutic strategies targeting gut microbiota to manage and prevent RAS, paving the way for novel interventions in this field.https://journal.adre.ro/the-impact-of-gut-microbiota-on-recurrent-aphthous-stomatitis/recurrent aphthous stomatitis; gut microbiota; oral health; intestinal dysbiosis; therapeutic strategies |
| spellingShingle | Mihaela Paula Toader Oana Mihaela Condurache Hritcu Cristina Popa Ana Maria Sciuca Bianca Andreea Onofrei Stefan Vasile Toader THE IMPACT OF GUT MICROBIOTA ON RECURRENT APHTHOUS STOMATITIS Romanian Journal of Medical and Dental Education recurrent aphthous stomatitis; gut microbiota; oral health; intestinal dysbiosis; therapeutic strategies |
| title | THE IMPACT OF GUT MICROBIOTA ON RECURRENT APHTHOUS STOMATITIS |
| title_full | THE IMPACT OF GUT MICROBIOTA ON RECURRENT APHTHOUS STOMATITIS |
| title_fullStr | THE IMPACT OF GUT MICROBIOTA ON RECURRENT APHTHOUS STOMATITIS |
| title_full_unstemmed | THE IMPACT OF GUT MICROBIOTA ON RECURRENT APHTHOUS STOMATITIS |
| title_short | THE IMPACT OF GUT MICROBIOTA ON RECURRENT APHTHOUS STOMATITIS |
| title_sort | impact of gut microbiota on recurrent aphthous stomatitis |
| topic | recurrent aphthous stomatitis; gut microbiota; oral health; intestinal dysbiosis; therapeutic strategies |
| url | https://journal.adre.ro/the-impact-of-gut-microbiota-on-recurrent-aphthous-stomatitis/ |
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