Disease stage-dependent changes in brain levels and neuroprotective effects of neuroactive steroids in Parkinson's disease

Disease stage-dependent changes in brain levels and neuroprotective effects of neuroactive steroids in Parkinson's disease

Neuroactive steroids are known neuroprotective agents and neurotransmitter regulators. We previously found that expression of the enzymes synthesizing 5α-dihydroprogesterone (5α-DHP), allopregnanolone (ALLO), and dehydroepiandrosterone sulfate (DHEAS) were reduced in the substantia nigra (SN) of Par...

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Bibliographic Details
Main Authors: Sabina Luchetti, Philippe Liere, Antoine Pianos, Ronald W.H. Verwer, Arja Sluiter, Inge Huitinga, Michael Schumacher, Dick F. Swaab, Matthew R.J. Mason
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Neurobiology of Disease
Subjects:
Neurosteroids
GC/MS
Allopregnanolone
5α-dihydroprogesterone
Slice culture
Post-mortem
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123001845

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