MuSK Myasthenia Gravis—Potential Pathomechanisms and Treatment Directed against Specific Targets
Myasthenia gravis (MG) is an autoimmune disease in which autoantibodies target structures within the neuromuscular junction, affecting neuromuscular transmission. Muscle-specific tyrosine kinase receptor-associated MG (MuSK-MG) is a rare, often more severe, subtype of the disease with different path...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/6/556 |
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| author | Edyta Dziadkowiak Dagmara Baczyńska Marta Waliszewska-Prosół |
| author_facet | Edyta Dziadkowiak Dagmara Baczyńska Marta Waliszewska-Prosół |
| author_sort | Edyta Dziadkowiak |
| collection | DOAJ |
| description | Myasthenia gravis (MG) is an autoimmune disease in which autoantibodies target structures within the neuromuscular junction, affecting neuromuscular transmission. Muscle-specific tyrosine kinase receptor-associated MG (MuSK-MG) is a rare, often more severe, subtype of the disease with different pathogenesis and specific clinical features. It is characterized by a more severe clinical course, more frequent complications, and often inadequate response to treatment. Here, we review the current state of knowledge about potential pathomechanisms of the MuSK-MG and their therapeutic implications as well as ongoing research in this field, with reference to key points of immune-mediated processes involved in the background of myasthenia gravis. |
| first_indexed | 2024-04-24T18:27:04Z |
| format | Article |
| id | doaj.art-98b845f2370246b7874d62e583fa0526 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-04-24T18:27:04Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-98b845f2370246b7874d62e583fa05262024-03-27T13:30:44ZengMDPI AGCells2073-44092024-03-0113655610.3390/cells13060556MuSK Myasthenia Gravis—Potential Pathomechanisms and Treatment Directed against Specific TargetsEdyta Dziadkowiak0Dagmara Baczyńska1Marta Waliszewska-Prosół2Department of Neurology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandDepartment of Molecular and Cellular Biology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, PolandDepartment of Neurology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandMyasthenia gravis (MG) is an autoimmune disease in which autoantibodies target structures within the neuromuscular junction, affecting neuromuscular transmission. Muscle-specific tyrosine kinase receptor-associated MG (MuSK-MG) is a rare, often more severe, subtype of the disease with different pathogenesis and specific clinical features. It is characterized by a more severe clinical course, more frequent complications, and often inadequate response to treatment. Here, we review the current state of knowledge about potential pathomechanisms of the MuSK-MG and their therapeutic implications as well as ongoing research in this field, with reference to key points of immune-mediated processes involved in the background of myasthenia gravis.https://www.mdpi.com/2073-4409/13/6/556myasthenia gravisMuSKneuromuscular diseaseautoimmune |
| spellingShingle | Edyta Dziadkowiak Dagmara Baczyńska Marta Waliszewska-Prosół MuSK Myasthenia Gravis—Potential Pathomechanisms and Treatment Directed against Specific Targets Cells myasthenia gravis MuSK neuromuscular disease autoimmune |
| title | MuSK Myasthenia Gravis—Potential Pathomechanisms and Treatment Directed against Specific Targets |
| title_full | MuSK Myasthenia Gravis—Potential Pathomechanisms and Treatment Directed against Specific Targets |
| title_fullStr | MuSK Myasthenia Gravis—Potential Pathomechanisms and Treatment Directed against Specific Targets |
| title_full_unstemmed | MuSK Myasthenia Gravis—Potential Pathomechanisms and Treatment Directed against Specific Targets |
| title_short | MuSK Myasthenia Gravis—Potential Pathomechanisms and Treatment Directed against Specific Targets |
| title_sort | musk myasthenia gravis potential pathomechanisms and treatment directed against specific targets |
| topic | myasthenia gravis MuSK neuromuscular disease autoimmune |
| url | https://www.mdpi.com/2073-4409/13/6/556 |
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