Molecular determinant deciphering of MIC-guided RND efflux substrates in E. coli

Molecular determinant deciphering of MIC-guided RND efflux substrates in E. coli

Antimicrobial resistance poses an urgent and formidable global public health threat. The escalation of bacterial multidrug resistance to antibiotics has the potential to become a leading cause of global mortality if there is no substantial improvement in antimicrobial development and therapy protoco...

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Bibliographic Details
Main Authors:	Johan Revol-Tissot, Gérard Boyer, Sandrine Alibert
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Series:	Frontiers in Drug Discovery
Subjects:	bacterial resistance Gram-negative Escherichia coli RND efflux pumps AcrAB-TolC multidrug resistance
Online Access:	https://www.frontiersin.org/articles/10.3389/fddsv.2024.1326121/full

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