Using diffusion tensor imaging to effectively target TMS to deep brain structures
TMS has become a powerful tool to explore cortical function, and in parallel has proven promising in the development of therapies for various psychiatric and neurological disorders. Unfortunately, much of the inference of the direct effects of TMS has been assumed to be limited to the area a few cen...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921011344 |
| _version_ | 1818940209673273344 |
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| author | Bruce Luber Simon W. Davis Zhi-De Deng David Murphy Andrew Martella Angel V. Peterchev Sarah H. Lisanby |
| author_facet | Bruce Luber Simon W. Davis Zhi-De Deng David Murphy Andrew Martella Angel V. Peterchev Sarah H. Lisanby |
| author_sort | Bruce Luber |
| collection | DOAJ |
| description | TMS has become a powerful tool to explore cortical function, and in parallel has proven promising in the development of therapies for various psychiatric and neurological disorders. Unfortunately, much of the inference of the direct effects of TMS has been assumed to be limited to the area a few centimeters beneath the scalp, though clearly more distant regions are likely to be influenced by structurally connected stimulation sites. In this study, we sought to develop a novel paradigm to individualize TMS coil placement to non-invasively achieve activation of specific deep brain targets of relevance to the treatment of psychiatric disorders. In ten subjects, structural diffusion imaging tractography data were used to identify an accessible cortical target in the right frontal pole that demonstrated both anatomic and functional connectivity to right Brodmann area 25 (BA25). Concurrent TMS-fMRI interleaving was used with a series of single, interleaved TMS pulses applied to the right frontal pole at four intensity levels ranging from 80% to 140% of motor threshold. In nine of ten subjects, TMS to the individualized frontal pole sites resulted in significant linear increase in BOLD activation of BA25 with increasing TMS intensity. The reliable activation of BA25 in a dosage-dependent manner suggests the possibility that the careful combination of imaging with TMS can make use of network properties to help overcome depth limitations and allow noninvasive brain stimulation to influence deep brain structures. |
| first_indexed | 2024-12-20T06:36:01Z |
| format | Article |
| id | doaj.art-98b9c401d37145acb28bb774c9c2b59a |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-20T06:36:01Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-98b9c401d37145acb28bb774c9c2b59a2022-12-21T19:49:59ZengElsevierNeuroImage1095-95722022-04-01249118863Using diffusion tensor imaging to effectively target TMS to deep brain structuresBruce Luber0Simon W. Davis1Zhi-De Deng2David Murphy3Andrew Martella4Angel V. Peterchev5Sarah H. Lisanby6Noninvasive Neuromodulation Unit, Experimental Therapeutics & Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States; Corresponding author.Department of Neurology, Duke University School of Medicine, Durham, NC, United StatesNoninvasive Neuromodulation Unit, Experimental Therapeutics & Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States; Department of Psychiatry & Behavioral Sciences, Duke University School of Medicine, Durham, NC, United StatesDepartment of Psychiatry & Behavioral Sciences, Duke University School of Medicine, Durham, NC, United StatesDepartment of Psychiatry & Behavioral Sciences, Duke University School of Medicine, Durham, NC, United StatesDepartment of Psychiatry & Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States; Department of Biomedical Engineering, Duke University, Durham, NC, United States; Department of Electrical and Computer Engineering, Duke University, Durham, NC, United States; Department of Neurosurgery, Duke University School of Medicine, Durham, NC, United StatesNoninvasive Neuromodulation Unit, Experimental Therapeutics & Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States; Department of Psychiatry & Behavioral Sciences, Duke University School of Medicine, Durham, NC, United StatesTMS has become a powerful tool to explore cortical function, and in parallel has proven promising in the development of therapies for various psychiatric and neurological disorders. Unfortunately, much of the inference of the direct effects of TMS has been assumed to be limited to the area a few centimeters beneath the scalp, though clearly more distant regions are likely to be influenced by structurally connected stimulation sites. In this study, we sought to develop a novel paradigm to individualize TMS coil placement to non-invasively achieve activation of specific deep brain targets of relevance to the treatment of psychiatric disorders. In ten subjects, structural diffusion imaging tractography data were used to identify an accessible cortical target in the right frontal pole that demonstrated both anatomic and functional connectivity to right Brodmann area 25 (BA25). Concurrent TMS-fMRI interleaving was used with a series of single, interleaved TMS pulses applied to the right frontal pole at four intensity levels ranging from 80% to 140% of motor threshold. In nine of ten subjects, TMS to the individualized frontal pole sites resulted in significant linear increase in BOLD activation of BA25 with increasing TMS intensity. The reliable activation of BA25 in a dosage-dependent manner suggests the possibility that the careful combination of imaging with TMS can make use of network properties to help overcome depth limitations and allow noninvasive brain stimulation to influence deep brain structures.http://www.sciencedirect.com/science/article/pii/S1053811921011344TMSConnectivityDiffusion imaging tractographyTargetingdeep brain stimulationSubgenual cingulate cortex |
| spellingShingle | Bruce Luber Simon W. Davis Zhi-De Deng David Murphy Andrew Martella Angel V. Peterchev Sarah H. Lisanby Using diffusion tensor imaging to effectively target TMS to deep brain structures NeuroImage TMS Connectivity Diffusion imaging tractography Targeting deep brain stimulation Subgenual cingulate cortex |
| title | Using diffusion tensor imaging to effectively target TMS to deep brain structures |
| title_full | Using diffusion tensor imaging to effectively target TMS to deep brain structures |
| title_fullStr | Using diffusion tensor imaging to effectively target TMS to deep brain structures |
| title_full_unstemmed | Using diffusion tensor imaging to effectively target TMS to deep brain structures |
| title_short | Using diffusion tensor imaging to effectively target TMS to deep brain structures |
| title_sort | using diffusion tensor imaging to effectively target tms to deep brain structures |
| topic | TMS Connectivity Diffusion imaging tractography Targeting deep brain stimulation Subgenual cingulate cortex |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921011344 |
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