T cell aging and Alzheimer’s disease
The brain has long been considered an immune-privileged organ due to the presence of the blood-brain barrier (BBB). However, recent discoveries have revealed the underestimated role of T cells in the brain through the meningeal lymphatic system. Age is the primary risk factor for Alzheimer’s disease...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1154699/full |
| _version_ | 1827973720958828544 |
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| author | Lin Guo Xiaoting Li Xiaoting Li Timothy Gould Zhan-You Wang Wenqiang Cao |
| author_facet | Lin Guo Xiaoting Li Xiaoting Li Timothy Gould Zhan-You Wang Wenqiang Cao |
| author_sort | Lin Guo |
| collection | DOAJ |
| description | The brain has long been considered an immune-privileged organ due to the presence of the blood-brain barrier (BBB). However, recent discoveries have revealed the underestimated role of T cells in the brain through the meningeal lymphatic system. Age is the primary risk factor for Alzheimer’s disease (AD), resulting in marked age-dependent changes in T cells. Manipulating peripheral T cell immune response has been shown to impact AD, but the relationship between T cell aging and AD remains poorly understood. Given the limited success of targeting amyloid beta (Aβ) and the growing evidence of T cells’ involvement in non-lymphoid organ aging, a deeper understanding of the relationship between T cells and AD in the context of aging is crucial for advancing therapeutic progress. In this review, we comprehensively examine existing studies on T cells and AD and offer an integrated perspective on their interconnections in the context of aging. This understanding can inform the development of new interventions to prevent or treat AD. |
| first_indexed | 2024-04-09T19:42:17Z |
| format | Article |
| id | doaj.art-98bb998c0e3b4ae5a4ce9523ec7532fe |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T19:42:17Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-98bb998c0e3b4ae5a4ce9523ec7532fe2023-04-04T05:24:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-04-011410.3389/fimmu.2023.11546991154699T cell aging and Alzheimer’s diseaseLin Guo0Xiaoting Li1Xiaoting Li2Timothy Gould3Zhan-You Wang4Wenqiang Cao5Key Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, Health Sciences Institute of China Medical University, Shenyang, ChinaKey Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, Health Sciences Institute of China Medical University, Shenyang, ChinaDepartment of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang, ChinaRubedo Life Sciences, Sunnyvale, CA, United StatesKey Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, Health Sciences Institute of China Medical University, Shenyang, ChinaKey Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, Health Sciences Institute of China Medical University, Shenyang, ChinaThe brain has long been considered an immune-privileged organ due to the presence of the blood-brain barrier (BBB). However, recent discoveries have revealed the underestimated role of T cells in the brain through the meningeal lymphatic system. Age is the primary risk factor for Alzheimer’s disease (AD), resulting in marked age-dependent changes in T cells. Manipulating peripheral T cell immune response has been shown to impact AD, but the relationship between T cell aging and AD remains poorly understood. Given the limited success of targeting amyloid beta (Aβ) and the growing evidence of T cells’ involvement in non-lymphoid organ aging, a deeper understanding of the relationship between T cells and AD in the context of aging is crucial for advancing therapeutic progress. In this review, we comprehensively examine existing studies on T cells and AD and offer an integrated perspective on their interconnections in the context of aging. This understanding can inform the development of new interventions to prevent or treat AD.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1154699/fullT cell agingAlzheimer’s disease (AD)thymic involutionsenescenceneuroinflammation |
| spellingShingle | Lin Guo Xiaoting Li Xiaoting Li Timothy Gould Zhan-You Wang Wenqiang Cao T cell aging and Alzheimer’s disease Frontiers in Immunology T cell aging Alzheimer’s disease (AD) thymic involution senescence neuroinflammation |
| title | T cell aging and Alzheimer’s disease |
| title_full | T cell aging and Alzheimer’s disease |
| title_fullStr | T cell aging and Alzheimer’s disease |
| title_full_unstemmed | T cell aging and Alzheimer’s disease |
| title_short | T cell aging and Alzheimer’s disease |
| title_sort | t cell aging and alzheimer s disease |
| topic | T cell aging Alzheimer’s disease (AD) thymic involution senescence neuroinflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1154699/full |
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