Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks.

Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks.

Genomic instability is a known precursor to cancer and aging. The RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key roles in maintaining genome stability in all living organisms. Human RecQ homologs include RECQ1, BLM, WRN, RECQ4, and RECQ5β, three of which have bee...

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Bibliographic Details
Main Authors:	Swetha Parvathaneni, Alexei Stortchevoi, Joshua A Sommers, Robert M Brosh, Sudha Sharma
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3641083?pdf=render

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