Sanguisorba officinalis L. suppresses non-small cell lung cancer via downregulating the PI3K/AKT/mTOR signaling pathway based on network pharmacology and experimental investigation

Sanguisorba officinalis L. suppresses non-small cell lung cancer via downregulating the PI3K/AKT/mTOR signaling pathway based on network pharmacology and experimental investigation

Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Sanguisorba officinalis L. (SOL), a traditional Chinese herbal medicine called Diyu, has been shown to have potent antitumor effects. However, the role of SOL in suppressing NSCLC remains unknown.Methods: Network...

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Bibliographic Details
Main Authors: Hong Li, Jing Lin, Fei Yang, Junzhu Deng, Jia Lai, Jing Zeng, Wenjun Zou, Nan Jiang, Qianqian Huang, Hua Li, Jian Liu, Mao Li, Zhirong Zhong, Jianming Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
Sanguisorba officinalis L.
non-small cell lung cancer
network pharmacology
PI3K/AKT/mTOR
ROS
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1054803/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1054803/full

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