In-Vitro characterization of gastroretentive microballoons prepared by the emulsion solvent diffusion method
Microballoons floatable on JPXIII No.1 solution were developed as a dosage form capable of floating in the stomach. Microballoons were prepared by the emulsion solvent diffusion method using enteric acrylic and other polymers with drug in a mixture of dichloromethane and ethanol. It was found that p...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-01-01
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| Series: | Journal of Advanced Pharmaceutical Technology & Research |
| Subjects: | |
| Online Access: | http://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=1;spage=56;epage=67;aulast=Yadav |
| _version_ | 1818136048182493184 |
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| author | Akash Yadav Dinesh Kumar Jain |
| author_facet | Akash Yadav Dinesh Kumar Jain |
| author_sort | Akash Yadav |
| collection | DOAJ |
| description | Microballoons floatable on JPXIII No.1 solution were developed as a dosage form capable of floating in the stomach. Microballoons were prepared by the emulsion solvent diffusion method using enteric acrylic and other polymers with drug in a mixture of dichloromethane and ethanol. It was found that preparation temperature determined the formation of cavity inside the microsphere and the surface smoothness, determining the floatability and the drug release rate of the microballoons. The correlation between the buoyancy of microballoons and their physical properties, e.g. apparent density and roundness of microballoons were elucidated. The drug loading efficiency of microballoons was also determined. The optimum loading amount of metformin in the microballoons was found to impart ideal floatable properties to the microballoons. By fitting the data into zero order, first order and Highuchi model it was concluded that the release followed zero order release. |
| first_indexed | 2024-12-11T09:34:12Z |
| format | Article |
| id | doaj.art-98c4e335a5614b0d96b666d9db10a7d0 |
| institution | Directory Open Access Journal |
| issn | 2231-4040 0976-2094 |
| language | English |
| last_indexed | 2024-12-11T09:34:12Z |
| publishDate | 2010-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Advanced Pharmaceutical Technology & Research |
| spelling | doaj.art-98c4e335a5614b0d96b666d9db10a7d02022-12-22T01:12:56ZengWolters Kluwer Medknow PublicationsJournal of Advanced Pharmaceutical Technology & Research2231-40400976-20942010-01-01115667In-Vitro characterization of gastroretentive microballoons prepared by the emulsion solvent diffusion methodAkash YadavDinesh Kumar JainMicroballoons floatable on JPXIII No.1 solution were developed as a dosage form capable of floating in the stomach. Microballoons were prepared by the emulsion solvent diffusion method using enteric acrylic and other polymers with drug in a mixture of dichloromethane and ethanol. It was found that preparation temperature determined the formation of cavity inside the microsphere and the surface smoothness, determining the floatability and the drug release rate of the microballoons. The correlation between the buoyancy of microballoons and their physical properties, e.g. apparent density and roundness of microballoons were elucidated. The drug loading efficiency of microballoons was also determined. The optimum loading amount of metformin in the microballoons was found to impart ideal floatable properties to the microballoons. By fitting the data into zero order, first order and Highuchi model it was concluded that the release followed zero order release.http://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=1;spage=56;epage=67;aulast=YadavFloating controlled drug delivery systemGastroretentiveMicroballoonsEmulsion solvent diffusion methodMetforminBuoyancy. |
| spellingShingle | Akash Yadav Dinesh Kumar Jain In-Vitro characterization of gastroretentive microballoons prepared by the emulsion solvent diffusion method Journal of Advanced Pharmaceutical Technology & Research Floating controlled drug delivery system Gastroretentive Microballoons Emulsion solvent diffusion method Metformin Buoyancy. |
| title | In-Vitro characterization of gastroretentive microballoons prepared by the emulsion solvent diffusion method |
| title_full | In-Vitro characterization of gastroretentive microballoons prepared by the emulsion solvent diffusion method |
| title_fullStr | In-Vitro characterization of gastroretentive microballoons prepared by the emulsion solvent diffusion method |
| title_full_unstemmed | In-Vitro characterization of gastroretentive microballoons prepared by the emulsion solvent diffusion method |
| title_short | In-Vitro characterization of gastroretentive microballoons prepared by the emulsion solvent diffusion method |
| title_sort | in vitro characterization of gastroretentive microballoons prepared by the emulsion solvent diffusion method |
| topic | Floating controlled drug delivery system Gastroretentive Microballoons Emulsion solvent diffusion method Metformin Buoyancy. |
| url | http://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=1;spage=56;epage=67;aulast=Yadav |
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