Cardiovascular Imaging for Systemic Sclerosis Monitoring and Management
Systemic sclerosis (SSc) is a complex connective tissue disease with multiple clinical and subclinical cardiac manifestations. SSc can affect most structural components of the heart, including the pericardium, myocardium, valves, and conduction system through a damaging cycle of inflammation, ischem...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.846213/full |
| _version_ | 1819156831788859392 |
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| author | Peter Glynn Sarah Hale Tasmeen Hussain Benjamin H. Freed |
| author_facet | Peter Glynn Sarah Hale Tasmeen Hussain Benjamin H. Freed |
| author_sort | Peter Glynn |
| collection | DOAJ |
| description | Systemic sclerosis (SSc) is a complex connective tissue disease with multiple clinical and subclinical cardiac manifestations. SSc can affect most structural components of the heart, including the pericardium, myocardium, valves, and conduction system through a damaging cycle of inflammation, ischemia, and fibrosis. While cardiac involvement is the second leading SSc-related cause of death, it is frequently clinically silent in early disease and often missed with routine screening. To facilitate identification of cardiac disease in this susceptible population, we present here a review of cardiac imaging modalities and potential uses in the SSc patient population. We describe well-characterized techniques including electrocardiography and 2D echocardiography with Doppler, but also discuss more advanced imaging approaches, such as speckle-tracking echocardiography, cardiovascular magnetic resonance imaging (CMR), and stress imaging, among others. We also suggest an algorithm for the appropriate application of these modalities in the workup and management of patients with SSc. Finally, we discuss future opportunities for cardiac imaging in SSc research to achieve early detection and to optimize treatment. |
| first_indexed | 2024-12-22T15:59:07Z |
| format | Article |
| id | doaj.art-98c7494cf94f42ac9be4cdc2ff34d397 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-22T15:59:07Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-98c7494cf94f42ac9be4cdc2ff34d3972022-12-21T18:20:43ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-03-01910.3389/fcvm.2022.846213846213Cardiovascular Imaging for Systemic Sclerosis Monitoring and ManagementPeter Glynn0Sarah Hale1Tasmeen Hussain2Benjamin H. Freed3Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDivision of Hospital Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesSystemic sclerosis (SSc) is a complex connective tissue disease with multiple clinical and subclinical cardiac manifestations. SSc can affect most structural components of the heart, including the pericardium, myocardium, valves, and conduction system through a damaging cycle of inflammation, ischemia, and fibrosis. While cardiac involvement is the second leading SSc-related cause of death, it is frequently clinically silent in early disease and often missed with routine screening. To facilitate identification of cardiac disease in this susceptible population, we present here a review of cardiac imaging modalities and potential uses in the SSc patient population. We describe well-characterized techniques including electrocardiography and 2D echocardiography with Doppler, but also discuss more advanced imaging approaches, such as speckle-tracking echocardiography, cardiovascular magnetic resonance imaging (CMR), and stress imaging, among others. We also suggest an algorithm for the appropriate application of these modalities in the workup and management of patients with SSc. Finally, we discuss future opportunities for cardiac imaging in SSc research to achieve early detection and to optimize treatment.https://www.frontiersin.org/articles/10.3389/fcvm.2022.846213/fullcardiovascular imagingsystemic sclerosis (scleroderma)echocardiographycardiovascular magnetic resonanacescleroderma heart disease |
| spellingShingle | Peter Glynn Sarah Hale Tasmeen Hussain Benjamin H. Freed Cardiovascular Imaging for Systemic Sclerosis Monitoring and Management Frontiers in Cardiovascular Medicine cardiovascular imaging systemic sclerosis (scleroderma) echocardiography cardiovascular magnetic resonanace scleroderma heart disease |
| title | Cardiovascular Imaging for Systemic Sclerosis Monitoring and Management |
| title_full | Cardiovascular Imaging for Systemic Sclerosis Monitoring and Management |
| title_fullStr | Cardiovascular Imaging for Systemic Sclerosis Monitoring and Management |
| title_full_unstemmed | Cardiovascular Imaging for Systemic Sclerosis Monitoring and Management |
| title_short | Cardiovascular Imaging for Systemic Sclerosis Monitoring and Management |
| title_sort | cardiovascular imaging for systemic sclerosis monitoring and management |
| topic | cardiovascular imaging systemic sclerosis (scleroderma) echocardiography cardiovascular magnetic resonanace scleroderma heart disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.846213/full |
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