Effects of Diosmin on Vascular Leakage and Inflammation in a Mouse Model of Venous Obstruction
At present, iliac vein compression syndrome (IVCS) plagues countless people, posing a significant economic and social burden. The progress of current IVCS-related research is slow owing to the limitations of animal models. In this study, we generated a mouse model of iliac vein stenosis (IVS) to mon...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.831485/full |
| _version_ | 1819279070148427776 |
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| author | Junjie Zou Dongping Yuan Jin Yang Yun Yu |
| author_facet | Junjie Zou Dongping Yuan Jin Yang Yun Yu |
| author_sort | Junjie Zou |
| collection | DOAJ |
| description | At present, iliac vein compression syndrome (IVCS) plagues countless people, posing a significant economic and social burden. The progress of current IVCS-related research is slow owing to the limitations of animal models. In this study, we generated a mouse model of iliac vein stenosis (IVS) to monitor the effects of IVCS on venous function, such as increased vascular leakage, the expression of adhesion molecules, and elevated inflammation factors. Diosmin, a widely used clinical bioactive ingredient, was administered to confirm its therapeutic effects on the IVS mouse model. The results revealed that diosmin manifested therapeutic improvement in the IVS mouse model. In addition, we verified that the IVS mouse model is a stable and reproducible animal model for pathophysiological studies. High-purity diosmin can be beneficial to venous dysfunction and hence provides a more effective treatment option for venous diseases. |
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| format | Article |
| id | doaj.art-98cb2216e20f4a049fdec3eb2cf0cd5c |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-24T00:22:03Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-98cb2216e20f4a049fdec3eb2cf0cd5c2022-12-21T17:24:34ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-02-01910.3389/fnut.2022.831485831485Effects of Diosmin on Vascular Leakage and Inflammation in a Mouse Model of Venous ObstructionJunjie Zou0Dongping Yuan1Jin Yang2Yun Yu3First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Vascular Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, ChinaAt present, iliac vein compression syndrome (IVCS) plagues countless people, posing a significant economic and social burden. The progress of current IVCS-related research is slow owing to the limitations of animal models. In this study, we generated a mouse model of iliac vein stenosis (IVS) to monitor the effects of IVCS on venous function, such as increased vascular leakage, the expression of adhesion molecules, and elevated inflammation factors. Diosmin, a widely used clinical bioactive ingredient, was administered to confirm its therapeutic effects on the IVS mouse model. The results revealed that diosmin manifested therapeutic improvement in the IVS mouse model. In addition, we verified that the IVS mouse model is a stable and reproducible animal model for pathophysiological studies. High-purity diosmin can be beneficial to venous dysfunction and hence provides a more effective treatment option for venous diseases.https://www.frontiersin.org/articles/10.3389/fnut.2022.831485/fulliliac vein compression syndromeiliac vein stenosisvenous permeabilityinflammationdiosmin |
| spellingShingle | Junjie Zou Dongping Yuan Jin Yang Yun Yu Effects of Diosmin on Vascular Leakage and Inflammation in a Mouse Model of Venous Obstruction Frontiers in Nutrition iliac vein compression syndrome iliac vein stenosis venous permeability inflammation diosmin |
| title | Effects of Diosmin on Vascular Leakage and Inflammation in a Mouse Model of Venous Obstruction |
| title_full | Effects of Diosmin on Vascular Leakage and Inflammation in a Mouse Model of Venous Obstruction |
| title_fullStr | Effects of Diosmin on Vascular Leakage and Inflammation in a Mouse Model of Venous Obstruction |
| title_full_unstemmed | Effects of Diosmin on Vascular Leakage and Inflammation in a Mouse Model of Venous Obstruction |
| title_short | Effects of Diosmin on Vascular Leakage and Inflammation in a Mouse Model of Venous Obstruction |
| title_sort | effects of diosmin on vascular leakage and inflammation in a mouse model of venous obstruction |
| topic | iliac vein compression syndrome iliac vein stenosis venous permeability inflammation diosmin |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.831485/full |
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