O-Acetylation is essential for functional antibody generation against Staphylococcus aureus capsular polysaccharide
Staphylococcus aureus produces an antiphagocytic polysaccharide capsule to evade neutrophil-mediated killing. Many vaccines against encapsulated bacterial pathogens require generation of functional anti-capsular antibodies to mediate protection against infection and disease. Here it is shown that th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-01-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2017.1386360 |
| _version_ | 1797677561427263488 |
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| author | Ingrid L. Scully Viliam Pavliak Yekaterina Timofeyeva Yongdong Liu Christine Singer Annaliesa S. Anderson |
| author_facet | Ingrid L. Scully Viliam Pavliak Yekaterina Timofeyeva Yongdong Liu Christine Singer Annaliesa S. Anderson |
| author_sort | Ingrid L. Scully |
| collection | DOAJ |
| description | Staphylococcus aureus produces an antiphagocytic polysaccharide capsule to evade neutrophil-mediated killing. Many vaccines against encapsulated bacterial pathogens require generation of functional anti-capsular antibodies to mediate protection against infection and disease. Here it is shown that the generation of such antibody responses to S. aureus in vivo and in vitro requires the presence of O-acetyl modifications on the capsular polysaccharides. O-acetylation of S. aureus capsular polysaccharide therefore should be monitored carefully during vaccine development and production. This finding may provide additional insight into the previous failure of a S. aureus capsular polysaccharide conjugate vaccine. |
| first_indexed | 2024-03-11T22:47:04Z |
| format | Article |
| id | doaj.art-98cb7ea7f294425caa9e2ed3b209d505 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:47:04Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-98cb7ea7f294425caa9e2ed3b209d5052023-09-22T08:17:52ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-01-01141818410.1080/21645515.2017.13863601386360O-Acetylation is essential for functional antibody generation against Staphylococcus aureus capsular polysaccharideIngrid L. Scully0Viliam Pavliak1Yekaterina Timofeyeva2Yongdong Liu3Christine Singer4Annaliesa S. Anderson5Pfizer Vaccine ResearchPfizer Vaccine ResearchPfizer Vaccine ResearchPfizer Vaccine ResearchPfizer Vaccine ResearchPfizer Vaccine ResearchStaphylococcus aureus produces an antiphagocytic polysaccharide capsule to evade neutrophil-mediated killing. Many vaccines against encapsulated bacterial pathogens require generation of functional anti-capsular antibodies to mediate protection against infection and disease. Here it is shown that the generation of such antibody responses to S. aureus in vivo and in vitro requires the presence of O-acetyl modifications on the capsular polysaccharides. O-acetylation of S. aureus capsular polysaccharide therefore should be monitored carefully during vaccine development and production. This finding may provide additional insight into the previous failure of a S. aureus capsular polysaccharide conjugate vaccine.http://dx.doi.org/10.1080/21645515.2017.1386360staphylococcus aureuscapsular polysaccharidevaccineantibody responseo-acetylation |
| spellingShingle | Ingrid L. Scully Viliam Pavliak Yekaterina Timofeyeva Yongdong Liu Christine Singer Annaliesa S. Anderson O-Acetylation is essential for functional antibody generation against Staphylococcus aureus capsular polysaccharide Human Vaccines & Immunotherapeutics staphylococcus aureus capsular polysaccharide vaccine antibody response o-acetylation |
| title | O-Acetylation is essential for functional antibody generation against Staphylococcus aureus capsular polysaccharide |
| title_full | O-Acetylation is essential for functional antibody generation against Staphylococcus aureus capsular polysaccharide |
| title_fullStr | O-Acetylation is essential for functional antibody generation against Staphylococcus aureus capsular polysaccharide |
| title_full_unstemmed | O-Acetylation is essential for functional antibody generation against Staphylococcus aureus capsular polysaccharide |
| title_short | O-Acetylation is essential for functional antibody generation against Staphylococcus aureus capsular polysaccharide |
| title_sort | o acetylation is essential for functional antibody generation against staphylococcus aureus capsular polysaccharide |
| topic | staphylococcus aureus capsular polysaccharide vaccine antibody response o-acetylation |
| url | http://dx.doi.org/10.1080/21645515.2017.1386360 |
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