Cortex periplocae modulates the gut microbiota to restrict colitis and colitis-associated colorectal cancer via suppression of pathogenic Th17 cells

Cortex periplocae modulates the gut microbiota to restrict colitis and colitis-associated colorectal cancer via suppression of pathogenic Th17 cells

Aberrant microbe-immune cell interaction is a predisposing factor in inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Cortex Periplocae is a famous traditional Chinese medicine with putative anti-rheumatoid arthritis and anti-dyspepsia effects. Here, we show that the Periploca s...

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Bibliographic Details
Main Authors: Zemin Lin, Li Chen, Mengnan Cheng, Fenghua Zhu, Xiaoqian Yang, Weimin Zhao, Jianping Zuo, Shijun He
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Colitis
Colitis-associated cancer
Periploca sepium periplosides
Gut microbiota
Intestinal Type 17 immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222007880

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