Effect of gravity on brain structure as indicated on upright computed tomography
Abstract We aimed to use upright computed tomography (CT) to depict posture-related changes in the brain tissue under normal gravity. Thirty-two asymptomatic volunteers underwent upright CT in the sitting position and conventional CT in the supine position on the same day. We compared the shift of t...
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| Format: | Article |
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Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-79695-z |
| _version_ | 1818734034401886208 |
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| author | Yoichi Yokoyama Yoshitake Yamada Kenzo Kosugi Minoru Yamada Keiichi Narita Takehiro Nakahara Hirokazu Fujiwara Masahiro Toda Masahiro Jinzaki |
| author_facet | Yoichi Yokoyama Yoshitake Yamada Kenzo Kosugi Minoru Yamada Keiichi Narita Takehiro Nakahara Hirokazu Fujiwara Masahiro Toda Masahiro Jinzaki |
| author_sort | Yoichi Yokoyama |
| collection | DOAJ |
| description | Abstract We aimed to use upright computed tomography (CT) to depict posture-related changes in the brain tissue under normal gravity. Thirty-two asymptomatic volunteers underwent upright CT in the sitting position and conventional CT in the supine position on the same day. We compared the shift of the pineal body, cerebellar tonsil, the length of pituitary stalk, optic nerve sheath area and perimeter (ONSA and ONSP, respectively), and lateral ventricular volume between the supine and sitting positions. We also compared shape changes of the cerebrospinal fluid (CSF) spaces at different sites between both positions. In the sitting position, the pineal body shifted 0.68 ± 0.27 mm in the ventral direction and 0.76 ± 0.24 mm in the caudal direction, the length of pituitary stalk decreased by 1.23 ± 0.71 mm, the cerebellar tonsil descended by 2.10 ± 0.86 mm, the right ONSA decreased by 15.21 ± 6.54%, the left ONSA decreased by 15.30 ± 7.37%, the right ONSP decreased by 8.52 ± 3.91%, the left ONSP decreased by 8.20 ± 4.38%, and the lateral ventricular volume decreased by 5.07 ± 3.24% (all P < 0.001). We also observed changes in the shape of CSF spaces with changes in posture. We concluded that the intracranial structure of healthy subjects and volume of ventricles changed according to posture on Earth. |
| first_indexed | 2024-12-17T23:58:56Z |
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| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T23:58:56Z |
| publishDate | 2021-01-01 |
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| series | Scientific Reports |
| spelling | doaj.art-98d03788ee2941bb81a81a146941d1772022-12-21T21:27:59ZengNature PortfolioScientific Reports2045-23222021-01-011111910.1038/s41598-020-79695-zEffect of gravity on brain structure as indicated on upright computed tomographyYoichi Yokoyama0Yoshitake Yamada1Kenzo Kosugi2Minoru Yamada3Keiichi Narita4Takehiro Nakahara5Hirokazu Fujiwara6Masahiro Toda7Masahiro Jinzaki8Department of Radiology, Keio University School of MedicineDepartment of Radiology, Keio University School of MedicineDepartment of Neurosurgery, Keio University School of MedicineDepartment of Radiology, Keio University School of MedicineDepartment of Radiology, Keio University School of MedicineDepartment of Radiology, Keio University School of MedicineDepartment of Radiology, Keio University School of MedicineDepartment of Neurosurgery, Keio University School of MedicineDepartment of Radiology, Keio University School of MedicineAbstract We aimed to use upright computed tomography (CT) to depict posture-related changes in the brain tissue under normal gravity. Thirty-two asymptomatic volunteers underwent upright CT in the sitting position and conventional CT in the supine position on the same day. We compared the shift of the pineal body, cerebellar tonsil, the length of pituitary stalk, optic nerve sheath area and perimeter (ONSA and ONSP, respectively), and lateral ventricular volume between the supine and sitting positions. We also compared shape changes of the cerebrospinal fluid (CSF) spaces at different sites between both positions. In the sitting position, the pineal body shifted 0.68 ± 0.27 mm in the ventral direction and 0.76 ± 0.24 mm in the caudal direction, the length of pituitary stalk decreased by 1.23 ± 0.71 mm, the cerebellar tonsil descended by 2.10 ± 0.86 mm, the right ONSA decreased by 15.21 ± 6.54%, the left ONSA decreased by 15.30 ± 7.37%, the right ONSP decreased by 8.52 ± 3.91%, the left ONSP decreased by 8.20 ± 4.38%, and the lateral ventricular volume decreased by 5.07 ± 3.24% (all P < 0.001). We also observed changes in the shape of CSF spaces with changes in posture. We concluded that the intracranial structure of healthy subjects and volume of ventricles changed according to posture on Earth.https://doi.org/10.1038/s41598-020-79695-z |
| spellingShingle | Yoichi Yokoyama Yoshitake Yamada Kenzo Kosugi Minoru Yamada Keiichi Narita Takehiro Nakahara Hirokazu Fujiwara Masahiro Toda Masahiro Jinzaki Effect of gravity on brain structure as indicated on upright computed tomography Scientific Reports |
| title | Effect of gravity on brain structure as indicated on upright computed tomography |
| title_full | Effect of gravity on brain structure as indicated on upright computed tomography |
| title_fullStr | Effect of gravity on brain structure as indicated on upright computed tomography |
| title_full_unstemmed | Effect of gravity on brain structure as indicated on upright computed tomography |
| title_short | Effect of gravity on brain structure as indicated on upright computed tomography |
| title_sort | effect of gravity on brain structure as indicated on upright computed tomography |
| url | https://doi.org/10.1038/s41598-020-79695-z |
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