Neither polyphenol-rich red wine nor fenofibrate affects the onset of type-1 diabetes mellitus in the BB rat
Abstract Serum levels of the pro-inflammatory apolipoprotein CIII (apoCIII) are increased in type-1 diabetic (T1D) patients and when β-cells are exposed to apoCIII they undergo apoptosis, which can be prevented by an antibody against apoCIII. We have previously investigated the BB rat, an animal mod...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | Laboratory Animal Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.5625/lar.2018.34.3.126 |
| _version_ | 1818019839802867712 |
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| author | Karin Åvall Per-Olof Berggren Lisa Juntti-Berggren |
| author_facet | Karin Åvall Per-Olof Berggren Lisa Juntti-Berggren |
| author_sort | Karin Åvall |
| collection | DOAJ |
| description | Abstract Serum levels of the pro-inflammatory apolipoprotein CIII (apoCIII) are increased in type-1 diabetic (T1D) patients and when β-cells are exposed to apoCIII they undergo apoptosis, which can be prevented by an antibody against apoCIII. We have previously investigated the BB rat, an animal model that develops a human-like T1D at the age of around 60 days, and found that apoCIII was also increased in sera from pre-diabetic rats and this promoted β-cell death. Lowering apoCIII with an oligonucleotide antisense during a phase of the pre-diabetic period prolonged the time to onset of T1D. In order to find other ways to lower apoCIII we in this study tested non-alcoholic red wine with medium and high concentrations of polyphenols and the lipid-lowering drug, fenofibrate, both reported to decrease the expression of apoCIII by activating peroxisome proliferator-activated receptors. Pre-diabetic BB-rats were treated orally for one month prior to the expected onset of diabetes with the two different wines or fenofibrate. None of the treatments prevented or prolonged the time to onset of diabetes and the expression of apoCIII was unaffected in this animal model for T1D. However, it must be emphasized that this does not exclude that other species can show a response to these substances. |
| first_indexed | 2024-04-14T07:56:52Z |
| format | Article |
| id | doaj.art-98d2e8fcf82c49deba4974996ca12354 |
| institution | Directory Open Access Journal |
| issn | 2233-7660 |
| language | English |
| last_indexed | 2024-04-14T07:56:52Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Laboratory Animal Research |
| spelling | doaj.art-98d2e8fcf82c49deba4974996ca123542022-12-22T02:05:01ZengBMCLaboratory Animal Research2233-76602018-12-0134312613110.5625/lar.2018.34.3.126Neither polyphenol-rich red wine nor fenofibrate affects the onset of type-1 diabetes mellitus in the BB ratKarin Åvall0Per-Olof Berggren1Lisa Juntti-Berggren2The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1Abstract Serum levels of the pro-inflammatory apolipoprotein CIII (apoCIII) are increased in type-1 diabetic (T1D) patients and when β-cells are exposed to apoCIII they undergo apoptosis, which can be prevented by an antibody against apoCIII. We have previously investigated the BB rat, an animal model that develops a human-like T1D at the age of around 60 days, and found that apoCIII was also increased in sera from pre-diabetic rats and this promoted β-cell death. Lowering apoCIII with an oligonucleotide antisense during a phase of the pre-diabetic period prolonged the time to onset of T1D. In order to find other ways to lower apoCIII we in this study tested non-alcoholic red wine with medium and high concentrations of polyphenols and the lipid-lowering drug, fenofibrate, both reported to decrease the expression of apoCIII by activating peroxisome proliferator-activated receptors. Pre-diabetic BB-rats were treated orally for one month prior to the expected onset of diabetes with the two different wines or fenofibrate. None of the treatments prevented or prolonged the time to onset of diabetes and the expression of apoCIII was unaffected in this animal model for T1D. However, it must be emphasized that this does not exclude that other species can show a response to these substances.http://link.springer.com/article/10.5625/lar.2018.34.3.126Apolipoprotein CIIIred winefenofibratediabetes |
| spellingShingle | Karin Åvall Per-Olof Berggren Lisa Juntti-Berggren Neither polyphenol-rich red wine nor fenofibrate affects the onset of type-1 diabetes mellitus in the BB rat Laboratory Animal Research Apolipoprotein CIII red wine fenofibrate diabetes |
| title | Neither polyphenol-rich red wine nor fenofibrate affects the onset of type-1 diabetes mellitus in the BB rat |
| title_full | Neither polyphenol-rich red wine nor fenofibrate affects the onset of type-1 diabetes mellitus in the BB rat |
| title_fullStr | Neither polyphenol-rich red wine nor fenofibrate affects the onset of type-1 diabetes mellitus in the BB rat |
| title_full_unstemmed | Neither polyphenol-rich red wine nor fenofibrate affects the onset of type-1 diabetes mellitus in the BB rat |
| title_short | Neither polyphenol-rich red wine nor fenofibrate affects the onset of type-1 diabetes mellitus in the BB rat |
| title_sort | neither polyphenol rich red wine nor fenofibrate affects the onset of type 1 diabetes mellitus in the bb rat |
| topic | Apolipoprotein CIII red wine fenofibrate diabetes |
| url | http://link.springer.com/article/10.5625/lar.2018.34.3.126 |
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