Non-steroidal FXR agonist cilofexor improves cholestatic liver injury in the Mdr2-/- mouse model of sclerosing cholangitis

Non-steroidal FXR agonist cilofexor improves cholestatic liver injury in the Mdr2-/- mouse model of sclerosing cholangitis

Background & Aims: The nuclear receptor farnesoid X receptor (FXR) is a key regulator of hepatic bile acid (BA) and lipid metabolism, inflammation and fibrosis. Here, we aimed to explore the potential of cilofexor (GS-9674), a non-steroidal FXR agonist, as a therapeutic approach for countera...

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Bibliographic Details
Main Authors: Claudia D. Fuchs, Natalie Sroda, Hubert Scharnagl, Ruchi Gupta, Wesley Minto, Tatjana Stojakovic, John T. Liles, Grant Budas, David Hollenback, Michael Trauner
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:JHEP Reports
Subjects:
Bile acid signaling
Inflammation Fibrosis
FXR, FGF15/19 Bile acid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923002057

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