ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells

ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells

Notch signaling is aberrantly activated in approximately 30% of hepatocellular carcinoma (HCC), significantly contributing to tumorigenesis and disease progression. Expression of the major Notch receptor, NOTCH1, is upregulated in HCC cells and correlates with advanced disease stages, although the m...

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Bibliographic Details
Main Authors: Tze‐Sian Chan, Li‐Hsin Cheng, Chung‐Chi Hsu, Pei‐Ming Yang, Tai‐Yan Liao, Hsiao‐Yen Hsieh, Pei‐Chun Lin, Wei‐Chun HuangFu, Chih‐Pin Chuu, Kelvin K. Tsai
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Molecular Oncology
Subjects:
ASPM
FBXW7
hepatocellular carcinoma
Notch signaling
NOTCH1
tumorigenesis
Online Access:https://doi.org/10.1002/1878-0261.13589

Internet

https://doi.org/10.1002/1878-0261.13589

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