Protein kinetics of superoxide dismutase‐1 in familial and sporadic amyotrophic lateral sclerosis

Protein kinetics of superoxide dismutase‐1 in familial and sporadic amyotrophic lateral sclerosis

Abstract Objective Accumulation of misfolded superoxide dismutase‐1 (SOD1) is a pathological hallmark of SOD1‐related amyotrophic lateral sclerosis (ALS) and is observed in sporadic ALS where its role in pathogenesis is controversial. Understanding in vivo protein kinetics may clarify how SOD1 influ...

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Bibliographic Details
Main Authors: Cindy V. Ly, Margaret D. Ireland, Wade K. Self, James Bollinger, Jennifer Jockel‐Balsarotti, Hillary Herzog, Peggy Allred, Leah Miller, Michael Doyle, Isabel Anez‐Bruzual, Bhavesh Trikamji, Ted Hyman, Tyler Kung, Katherine Nicholson, Robert C. Bucelli, Bruce W. Patterson, Randall J. Bateman, Timothy M. Miller
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.51784

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