Proinflammatory cytokines and depression in rheumatoid arthritis
Objective: to specify the association between the levels of proinflammatory cytokines, such as tumor necrosis factor-а (TNF-а), interleukin-1 β (IL-1 β), and IL-6, and the presence and degree of depression and anxiety spectrum disorders (ADSDs) in patients with rheumatoid arthritis (RA). Subjects an...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2013-06-01
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| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1314 |
| _version_ | 1797862797850181632 |
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| author | Tatyana Andreyevna Lisitsyna D Yu Veltishchev O F Seravina O B Kovalevskaya A E Zeltyn A A Novikov E N Aleksandrova V N Krasnov E L Nasonov |
| author_facet | Tatyana Andreyevna Lisitsyna D Yu Veltishchev O F Seravina O B Kovalevskaya A E Zeltyn A A Novikov E N Aleksandrova V N Krasnov E L Nasonov |
| author_sort | Tatyana Andreyevna Lisitsyna |
| collection | DOAJ |
| description | Objective: to specify the association between the levels of proinflammatory cytokines, such as tumor necrosis factor-а (TNF-а), interleukin-1 β (IL-1 β), and IL-6, and the presence and degree of depression and anxiety spectrum disorders (ADSDs) in patients with rheumatoid arthritis (RA). Subjects and methods. The investigation included 45 patients with a valid RA diagnosis. Their mean age was 45.5+3.09 years; the mean disease duration was 155.0+26.5 months. The authors determined RA activity with the DAS28 index; fatigue degree with the Fatigue Severity Scale (FSS), and pain magnitude with the Brief Pain Inventory (BPI). Mental disorders were diagnosed by a psychiatrist in accordance with the ICD-10 and DSM-IV, by applying a number of psychiatric and psychological scales and tests. The concentration of proinflammatory cytokines was measured using the xMAP (27-plex) technology on a BioPlex-200 analyzer (Bio-Rad, USA). Results. There were mental ADSDs in 82.2% of the patients and moderate cognitive impairments (CI) in 67.7%. 80% of the examinees reported clinical fatigue; 64.5% experienced severe and moderate pain. The levels of TNF-а and IL-1ß were slightly higher in patients with ADSDs and CI than in those without these disorders. The concentration of IL-6 was highest in the presence of anxiety disorders. However, these differences were statistically insignificant. The level of TNF-а was somewhat higher in patients with clinical fatigue and significantly higher in those who experienced intense pain. That of IL-1ß was significantly higher in patients with severe and moderate pain than in those with mild pain (p < 0.05). Conclusion. ADSDs and CI in patients with RA are associated with the elevated levels of proinflammatory cytokines (TNF-а, IL-1ß, and IL-6), which confirms the implication of chronic inflammation in the pathogenesis of these conditions in RA. High TNF-а and IL-1ß levels are typical of RA patients with clinical fatigue and marked pain. |
| first_indexed | 2024-04-09T22:25:22Z |
| format | Article |
| id | doaj.art-98d5485f273f427ca5fdad9f0ea60e3b |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:25:22Z |
| publishDate | 2013-06-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-98d5485f273f427ca5fdad9f0ea60e3b2023-03-22T13:45:48ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922013-06-0151326126610.14412/1995-4484-2013-14981254Proinflammatory cytokines and depression in rheumatoid arthritisTatyana Andreyevna LisitsynaD Yu VeltishchevO F SeravinaO B KovalevskayaA E ZeltynA A NovikovE N AleksandrovaV N KrasnovE L NasonovObjective: to specify the association between the levels of proinflammatory cytokines, such as tumor necrosis factor-а (TNF-а), interleukin-1 β (IL-1 β), and IL-6, and the presence and degree of depression and anxiety spectrum disorders (ADSDs) in patients with rheumatoid arthritis (RA). Subjects and methods. The investigation included 45 patients with a valid RA diagnosis. Their mean age was 45.5+3.09 years; the mean disease duration was 155.0+26.5 months. The authors determined RA activity with the DAS28 index; fatigue degree with the Fatigue Severity Scale (FSS), and pain magnitude with the Brief Pain Inventory (BPI). Mental disorders were diagnosed by a psychiatrist in accordance with the ICD-10 and DSM-IV, by applying a number of psychiatric and psychological scales and tests. The concentration of proinflammatory cytokines was measured using the xMAP (27-plex) technology on a BioPlex-200 analyzer (Bio-Rad, USA). Results. There were mental ADSDs in 82.2% of the patients and moderate cognitive impairments (CI) in 67.7%. 80% of the examinees reported clinical fatigue; 64.5% experienced severe and moderate pain. The levels of TNF-а and IL-1ß were slightly higher in patients with ADSDs and CI than in those without these disorders. The concentration of IL-6 was highest in the presence of anxiety disorders. However, these differences were statistically insignificant. The level of TNF-а was somewhat higher in patients with clinical fatigue and significantly higher in those who experienced intense pain. That of IL-1ß was significantly higher in patients with severe and moderate pain than in those with mild pain (p < 0.05). Conclusion. ADSDs and CI in patients with RA are associated with the elevated levels of proinflammatory cytokines (TNF-а, IL-1ß, and IL-6), which confirms the implication of chronic inflammation in the pathogenesis of these conditions in RA. High TNF-а and IL-1ß levels are typical of RA patients with clinical fatigue and marked pain.https://rsp.mediar-press.net/rsp/article/view/1314rheumatoid arthritisdepressionfatiguepaininflammationproinflammatory cytokines |
| spellingShingle | Tatyana Andreyevna Lisitsyna D Yu Veltishchev O F Seravina O B Kovalevskaya A E Zeltyn A A Novikov E N Aleksandrova V N Krasnov E L Nasonov Proinflammatory cytokines and depression in rheumatoid arthritis Научно-практическая ревматология rheumatoid arthritis depression fatigue pain inflammation proinflammatory cytokines |
| title | Proinflammatory cytokines and depression in rheumatoid arthritis |
| title_full | Proinflammatory cytokines and depression in rheumatoid arthritis |
| title_fullStr | Proinflammatory cytokines and depression in rheumatoid arthritis |
| title_full_unstemmed | Proinflammatory cytokines and depression in rheumatoid arthritis |
| title_short | Proinflammatory cytokines and depression in rheumatoid arthritis |
| title_sort | proinflammatory cytokines and depression in rheumatoid arthritis |
| topic | rheumatoid arthritis depression fatigue pain inflammation proinflammatory cytokines |
| url | https://rsp.mediar-press.net/rsp/article/view/1314 |
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