Natural killer cell activity as a biomarker for the diagnosis of lung cancer in high-risk patients
Objective Natural killer (NK) cells play an essential role in the immune response against cancer. However, immune escape mechanisms may cause inferior NK cell activity (NKA) in patients with cancer. This prospective study examined the relationship between NKA and lung cancer in a high-risk cohort. M...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-06-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221108924 |
| _version_ | 1828723747054419968 |
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| author | Morten Borg Sara Witting Christensen Wen Torben Frøstrup Hansen Anders Jakobsen Rikke Fredslund Andersen Ole Hilberg Ulla Møller Weinreich Line Nederby |
| author_facet | Morten Borg Sara Witting Christensen Wen Torben Frøstrup Hansen Anders Jakobsen Rikke Fredslund Andersen Ole Hilberg Ulla Møller Weinreich Line Nederby |
| author_sort | Morten Borg |
| collection | DOAJ |
| description | Objective Natural killer (NK) cells play an essential role in the immune response against cancer. However, immune escape mechanisms may cause inferior NK cell activity (NKA) in patients with cancer. This prospective study examined the relationship between NKA and lung cancer in a high-risk cohort. Methods In a cohort study, 250 participants referred by their general practitioner for suspicion of lung cancer were included. Before clinical investigation, blood was collected into NK Vue tubes, and the level of interferon gamma after 24 hours served as a surrogate marker for NKA. Results Among 250 patients, 79 were diagnosed with lung cancer. No difference in NKA was found between patients with lung cancer and control participants in which lung cancer was ruled out (median 226 pg/mL vs. 450 pg/mL). However, there was a significant difference in NKA between patients with late-stage lung cancer and controls (median 161 pg/mL vs. 450 pg/mL). A linear regression model showed that NKA was not influenced by age, sex or smoking status. Conclusions The significantly lower NKA in patients with late-stage lung cancer warrants further investigation combining NKA with other biomarkers and examining the potential role of NKA as a marker of disseminated disease. |
| first_indexed | 2024-04-12T12:56:13Z |
| format | Article |
| id | doaj.art-98d79f5b73f64adfaed8e24a84beff98 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-04-12T12:56:13Z |
| publishDate | 2022-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-98d79f5b73f64adfaed8e24a84beff982022-12-22T03:32:20ZengSAGE PublishingJournal of International Medical Research1473-23002022-06-015010.1177/03000605221108924Natural killer cell activity as a biomarker for the diagnosis of lung cancer in high-risk patientsMorten BorgSara Witting Christensen WenTorben Frøstrup HansenAnders JakobsenRikke Fredslund AndersenOle HilbergUlla Møller WeinreichLine NederbyObjective Natural killer (NK) cells play an essential role in the immune response against cancer. However, immune escape mechanisms may cause inferior NK cell activity (NKA) in patients with cancer. This prospective study examined the relationship between NKA and lung cancer in a high-risk cohort. Methods In a cohort study, 250 participants referred by their general practitioner for suspicion of lung cancer were included. Before clinical investigation, blood was collected into NK Vue tubes, and the level of interferon gamma after 24 hours served as a surrogate marker for NKA. Results Among 250 patients, 79 were diagnosed with lung cancer. No difference in NKA was found between patients with lung cancer and control participants in which lung cancer was ruled out (median 226 pg/mL vs. 450 pg/mL). However, there was a significant difference in NKA between patients with late-stage lung cancer and controls (median 161 pg/mL vs. 450 pg/mL). A linear regression model showed that NKA was not influenced by age, sex or smoking status. Conclusions The significantly lower NKA in patients with late-stage lung cancer warrants further investigation combining NKA with other biomarkers and examining the potential role of NKA as a marker of disseminated disease.https://doi.org/10.1177/03000605221108924 |
| spellingShingle | Morten Borg Sara Witting Christensen Wen Torben Frøstrup Hansen Anders Jakobsen Rikke Fredslund Andersen Ole Hilberg Ulla Møller Weinreich Line Nederby Natural killer cell activity as a biomarker for the diagnosis of lung cancer in high-risk patients Journal of International Medical Research |
| title | Natural killer cell activity as a biomarker for the diagnosis of lung cancer in high-risk patients |
| title_full | Natural killer cell activity as a biomarker for the diagnosis of lung cancer in high-risk patients |
| title_fullStr | Natural killer cell activity as a biomarker for the diagnosis of lung cancer in high-risk patients |
| title_full_unstemmed | Natural killer cell activity as a biomarker for the diagnosis of lung cancer in high-risk patients |
| title_short | Natural killer cell activity as a biomarker for the diagnosis of lung cancer in high-risk patients |
| title_sort | natural killer cell activity as a biomarker for the diagnosis of lung cancer in high risk patients |
| url | https://doi.org/10.1177/03000605221108924 |
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