Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism
Abstract Aging is the basis for several unfavorable conditions, including cardiovascular diseases (CVDs). In this sense, regular physical activity (regular PA) has been proven to delay cellular aging and prevent endothelial dysfunction related to CVDs. Despite numerous studies involving athletes, li...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-44928-4 |
| _version_ | 1797452864371556352 |
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| author | Giorgia Scarfò Simona Daniele Elisa Chelucci Antonio Rizza Jonathan Fusi Giancarlo Freggia Barbara Costa Sabrina Taliani Paolo Artini Claudia Martini Ferdinando Franzoni |
| author_facet | Giorgia Scarfò Simona Daniele Elisa Chelucci Antonio Rizza Jonathan Fusi Giancarlo Freggia Barbara Costa Sabrina Taliani Paolo Artini Claudia Martini Ferdinando Franzoni |
| author_sort | Giorgia Scarfò |
| collection | DOAJ |
| description | Abstract Aging is the basis for several unfavorable conditions, including cardiovascular diseases (CVDs). In this sense, regular physical activity (regular PA) has been proven to delay cellular aging and prevent endothelial dysfunction related to CVDs. Despite numerous studies involving athletes, little is known about cellular and molecular mechanisms of regular PA among master athletes. The present study aimed at evaluating the effects of regular PA on local microcirculatory functions in elderly athletes as compared to age-matched sedentary controls. Moreover, molecular/epigenetic mechanisms (nitric oxide, oxidative stress, PGC-1α, SIRT1 and miR29) were also assessed. The results of the present study showed that regular PA significantly increased local blood flow in post-ischemia and post-heating conditions, as well as NO plasma concentrations, denoting a better endothelial function/microcirculatory efficiency. Moreover, athletes presented a greater plasma antioxidant and increased transcriptional levels of the metabolism regulator PGC-1α. Finally, regular PA enhanced plasma level of SIRT1 and miR29, suggested as epigenetic regulators of redox balance and cellular metabolism. In addition, stimulated local blood flow was directly related to plasma antioxidant capacity, and SIRT1 and miR29 levels. Overall, our data confirm the beneficial effects of regular PA on the cardiovascular profile in elderly athletes and shed light on molecular signals involved in the positive adaptations to exercise. |
| first_indexed | 2024-03-09T15:14:48Z |
| format | Article |
| id | doaj.art-98d7a62f885f419c9e9fba17176573c3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:14:48Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-98d7a62f885f419c9e9fba17176573c32023-11-26T13:10:52ZengNature PortfolioScientific Reports2045-23222023-10-0113111010.1038/s41598-023-44928-4Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolismGiorgia Scarfò0Simona Daniele1Elisa Chelucci2Antonio Rizza3Jonathan Fusi4Giancarlo Freggia5Barbara Costa6Sabrina Taliani7Paolo Artini8Claudia Martini9Ferdinando Franzoni10Division of General Medicine, Department of Clinical and Experimental Medicine, University of PisaDepartment of Pharmacy, University of PisaDepartment of Pharmacy, University of PisaInterventional Cardiology Division, Gaetano Pasquinucci Heart Hospital, Fondazione Toscana Gabriele MonasterioDivision of General Medicine, Department of Clinical and Experimental Medicine, University of PisaCardiology Unit, Gaetano Pasquinucci Heart Hospital, Fondazione Toscana Gabriele MonasterioDepartment of Pharmacy, University of PisaDepartment of Pharmacy, University of PisaDivision of Gynecology and Obstetrics, Department of Clinical and Experimental Medicine, University of PisaDepartment of Pharmacy, University of PisaDivision of General Medicine, Department of Clinical and Experimental Medicine, University of PisaAbstract Aging is the basis for several unfavorable conditions, including cardiovascular diseases (CVDs). In this sense, regular physical activity (regular PA) has been proven to delay cellular aging and prevent endothelial dysfunction related to CVDs. Despite numerous studies involving athletes, little is known about cellular and molecular mechanisms of regular PA among master athletes. The present study aimed at evaluating the effects of regular PA on local microcirculatory functions in elderly athletes as compared to age-matched sedentary controls. Moreover, molecular/epigenetic mechanisms (nitric oxide, oxidative stress, PGC-1α, SIRT1 and miR29) were also assessed. The results of the present study showed that regular PA significantly increased local blood flow in post-ischemia and post-heating conditions, as well as NO plasma concentrations, denoting a better endothelial function/microcirculatory efficiency. Moreover, athletes presented a greater plasma antioxidant and increased transcriptional levels of the metabolism regulator PGC-1α. Finally, regular PA enhanced plasma level of SIRT1 and miR29, suggested as epigenetic regulators of redox balance and cellular metabolism. In addition, stimulated local blood flow was directly related to plasma antioxidant capacity, and SIRT1 and miR29 levels. Overall, our data confirm the beneficial effects of regular PA on the cardiovascular profile in elderly athletes and shed light on molecular signals involved in the positive adaptations to exercise.https://doi.org/10.1038/s41598-023-44928-4 |
| spellingShingle | Giorgia Scarfò Simona Daniele Elisa Chelucci Antonio Rizza Jonathan Fusi Giancarlo Freggia Barbara Costa Sabrina Taliani Paolo Artini Claudia Martini Ferdinando Franzoni Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism Scientific Reports |
| title | Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism |
| title_full | Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism |
| title_fullStr | Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism |
| title_full_unstemmed | Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism |
| title_short | Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism |
| title_sort | regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism |
| url | https://doi.org/10.1038/s41598-023-44928-4 |
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