Role of Cell Death in Cellular Processes During Odontogenesis
The development of a tooth germ in a precise size, shape, and position in the jaw, involves meticulous regulation of cell proliferation and cell death. Apoptosis, as the most common type of programmed cell death during embryonic development, plays a number of key roles during odontogenesis, ranging...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.671475/full |
| _version_ | 1819045361067491328 |
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| author | John Abramyan Poongodi Geetha-Loganathan Marie Šulcová Marie Šulcová Marcela Buchtová Marcela Buchtová |
| author_facet | John Abramyan Poongodi Geetha-Loganathan Marie Šulcová Marie Šulcová Marcela Buchtová Marcela Buchtová |
| author_sort | John Abramyan |
| collection | DOAJ |
| description | The development of a tooth germ in a precise size, shape, and position in the jaw, involves meticulous regulation of cell proliferation and cell death. Apoptosis, as the most common type of programmed cell death during embryonic development, plays a number of key roles during odontogenesis, ranging from the budding of the oral epithelium during tooth initiation, to later tooth germ morphogenesis and removal of enamel knot signaling center. Here, we summarize recent knowledge about the distribution and function of apoptotic cells during odontogenesis in several vertebrate lineages, with a special focus on amniotes (mammals and reptiles). We discuss the regulatory roles that apoptosis plays on various cellular processes during odontogenesis. We also review apoptosis-associated molecular signaling during tooth development, including its relationship with the autophagic pathway. Lastly, we cover apoptotic pathway disruption, and alterations in apoptotic cell distribution in transgenic mouse models. These studies foster a deeper understanding how apoptotic cells affect cellular processes during normal odontogenesis, and how they contribute to dental disorders, which could lead to new avenues of treatment in the future. |
| first_indexed | 2024-12-21T10:27:21Z |
| format | Article |
| id | doaj.art-98d900b407ee4f85b18ed8cf7506da63 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-21T10:27:21Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-98d900b407ee4f85b18ed8cf7506da632022-12-21T19:07:17ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-06-01910.3389/fcell.2021.671475671475Role of Cell Death in Cellular Processes During OdontogenesisJohn Abramyan0Poongodi Geetha-Loganathan1Marie Šulcová2Marie Šulcová3Marcela Buchtová4Marcela Buchtová5Department of Natural Sciences, University of Michigan–Dearborn, Dearborn, MI, United StatesDepartment of Biological Sciences, SUNY Oswego, Oswego, NY, United StatesDepartment of Experimental Biology, Faculty of Science, Masaryk University, Brno, CzechiaLaboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, CzechiaDepartment of Experimental Biology, Faculty of Science, Masaryk University, Brno, CzechiaLaboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, CzechiaThe development of a tooth germ in a precise size, shape, and position in the jaw, involves meticulous regulation of cell proliferation and cell death. Apoptosis, as the most common type of programmed cell death during embryonic development, plays a number of key roles during odontogenesis, ranging from the budding of the oral epithelium during tooth initiation, to later tooth germ morphogenesis and removal of enamel knot signaling center. Here, we summarize recent knowledge about the distribution and function of apoptotic cells during odontogenesis in several vertebrate lineages, with a special focus on amniotes (mammals and reptiles). We discuss the regulatory roles that apoptosis plays on various cellular processes during odontogenesis. We also review apoptosis-associated molecular signaling during tooth development, including its relationship with the autophagic pathway. Lastly, we cover apoptotic pathway disruption, and alterations in apoptotic cell distribution in transgenic mouse models. These studies foster a deeper understanding how apoptotic cells affect cellular processes during normal odontogenesis, and how they contribute to dental disorders, which could lead to new avenues of treatment in the future.https://www.frontiersin.org/articles/10.3389/fcell.2021.671475/fullteethdental laminaapoptosisodontogenesismorphogenesis |
| spellingShingle | John Abramyan Poongodi Geetha-Loganathan Marie Šulcová Marie Šulcová Marcela Buchtová Marcela Buchtová Role of Cell Death in Cellular Processes During Odontogenesis Frontiers in Cell and Developmental Biology teeth dental lamina apoptosis odontogenesis morphogenesis |
| title | Role of Cell Death in Cellular Processes During Odontogenesis |
| title_full | Role of Cell Death in Cellular Processes During Odontogenesis |
| title_fullStr | Role of Cell Death in Cellular Processes During Odontogenesis |
| title_full_unstemmed | Role of Cell Death in Cellular Processes During Odontogenesis |
| title_short | Role of Cell Death in Cellular Processes During Odontogenesis |
| title_sort | role of cell death in cellular processes during odontogenesis |
| topic | teeth dental lamina apoptosis odontogenesis morphogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.671475/full |
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