Effect of double dose plateletpheresis on target yield and donor platelet recovery
Introduction: The demand for apheresis platelets has increased in the recent past and the shrinking donor pool has shifted the trend to collection of double-dose or higher yield of platelets. Objective: The present study aimed to determine the effect of double-dose plateletpheresis on the target yie...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Hematology, Transfusion and Cell Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137921000833 |
| _version_ | 1811172216838029312 |
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| author | Sapna Chopra Paramjit Kaur Ravneet Kaur Bedi Gagandeep Kaur |
| author_facet | Sapna Chopra Paramjit Kaur Ravneet Kaur Bedi Gagandeep Kaur |
| author_sort | Sapna Chopra |
| collection | DOAJ |
| description | Introduction: The demand for apheresis platelets has increased in the recent past and the shrinking donor pool has shifted the trend to collection of double-dose or higher yield of platelets. Objective: The present study aimed to determine the effect of double-dose plateletpheresis on the target yield and donor platelet recovery. Methods: The study was conducted on 100 healthy plateletpheresis donors, 50 of whom were in the study group, which underwent double-dose plateletpheresis (DDP), and 50 of whom were in the control group for single-donor plateletpheresis. Pre- and post-procedure samples of donors were subjected to a complete blood count. The DDP product was sampled for platelet yield and then split into two parts. Platelet yield, collection efficiency, collection rate, recruitment factor and donor platelet loss were calculated. Results: The mean platelet yield in the SDP was 4.09 ± 1.15 × 1011 and in the DDP, 5.93 ± 1.04 × 1011. There was a significant correlation between the pre-donation platelet count and platelet yield. The total of platelets processed for the SDP were 5.42 ± 1.08 × 1011 and for the DDP, 7.94 ± 0.77 × 1011. The collection efficiency was 71.93 ± 25.14% in the SDP and 72.94 ± 16.28% in the DDP, while the collection rates were 0.78 × 1011 and 0.94 × 1011 per minute, respectively. The average recruitment factor observed was 0.98 in the SDP, while it was 0.99 in the DDP. The mean platelet loss observed in the SDP was 35.55 ± 8.53% and in the DDP, 37.76 ± 8.65%. Conclusion: The double-dose plateletpheresis supplements the platelet inventory in developing countries where the apheresis donor pool is limited. It is prudent to ensure stringent donor selection criteria for donors donating high-yield platelet products, thus enhancing donor safety and retention. |
| first_indexed | 2024-04-10T17:26:07Z |
| format | Article |
| id | doaj.art-98dab9f951c44397bfcc381872024cff |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-04-10T17:26:07Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-98dab9f951c44397bfcc381872024cff2023-02-04T04:18:24ZengElsevierHematology, Transfusion and Cell Therapy2531-13792023-01-014511624Effect of double dose plateletpheresis on target yield and donor platelet recoverySapna Chopra0Paramjit Kaur1Ravneet Kaur Bedi2Gagandeep Kaur3All India Institute of Medical Sciences, Ansari Nagar, New Delhi, IndiaGovernment Medical College and Hospital, Sector 32, Chandigarh, India; Corresponding Author at: Department of Transfusion Medicine, Government Medical College and Hospital, Sector 32-B, Chandigarh, India, Postal code 160030, Phone: 91 172 2601023. Ext 2210.Government Medical College and Hospital, Sector 32, Chandigarh, IndiaGovernment Medical College and Hospital, Sector 32, Chandigarh, IndiaIntroduction: The demand for apheresis platelets has increased in the recent past and the shrinking donor pool has shifted the trend to collection of double-dose or higher yield of platelets. Objective: The present study aimed to determine the effect of double-dose plateletpheresis on the target yield and donor platelet recovery. Methods: The study was conducted on 100 healthy plateletpheresis donors, 50 of whom were in the study group, which underwent double-dose plateletpheresis (DDP), and 50 of whom were in the control group for single-donor plateletpheresis. Pre- and post-procedure samples of donors were subjected to a complete blood count. The DDP product was sampled for platelet yield and then split into two parts. Platelet yield, collection efficiency, collection rate, recruitment factor and donor platelet loss were calculated. Results: The mean platelet yield in the SDP was 4.09 ± 1.15 × 1011 and in the DDP, 5.93 ± 1.04 × 1011. There was a significant correlation between the pre-donation platelet count and platelet yield. The total of platelets processed for the SDP were 5.42 ± 1.08 × 1011 and for the DDP, 7.94 ± 0.77 × 1011. The collection efficiency was 71.93 ± 25.14% in the SDP and 72.94 ± 16.28% in the DDP, while the collection rates were 0.78 × 1011 and 0.94 × 1011 per minute, respectively. The average recruitment factor observed was 0.98 in the SDP, while it was 0.99 in the DDP. The mean platelet loss observed in the SDP was 35.55 ± 8.53% and in the DDP, 37.76 ± 8.65%. Conclusion: The double-dose plateletpheresis supplements the platelet inventory in developing countries where the apheresis donor pool is limited. It is prudent to ensure stringent donor selection criteria for donors donating high-yield platelet products, thus enhancing donor safety and retention.http://www.sciencedirect.com/science/article/pii/S2531137921000833Double-dose plateletpheresisRecruitment factorAdverse reactionsPlatelet recovery |
| spellingShingle | Sapna Chopra Paramjit Kaur Ravneet Kaur Bedi Gagandeep Kaur Effect of double dose plateletpheresis on target yield and donor platelet recovery Hematology, Transfusion and Cell Therapy Double-dose plateletpheresis Recruitment factor Adverse reactions Platelet recovery |
| title | Effect of double dose plateletpheresis on target yield and donor platelet recovery |
| title_full | Effect of double dose plateletpheresis on target yield and donor platelet recovery |
| title_fullStr | Effect of double dose plateletpheresis on target yield and donor platelet recovery |
| title_full_unstemmed | Effect of double dose plateletpheresis on target yield and donor platelet recovery |
| title_short | Effect of double dose plateletpheresis on target yield and donor platelet recovery |
| title_sort | effect of double dose plateletpheresis on target yield and donor platelet recovery |
| topic | Double-dose plateletpheresis Recruitment factor Adverse reactions Platelet recovery |
| url | http://www.sciencedirect.com/science/article/pii/S2531137921000833 |
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