Practice of Childhood Nephrotic Syndrome Management amongPediatric Nephrologists in the GCC Countries
Childhood nephrotic syndrome (NS) management is greatly variable among pediatric nephrologists worldwide. We aimed to evaluate if this variability exists among pediatric nephrologists in the gulf countries and whether certain training programs influence this variability. A web-based multiple-choice...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2021;volume=32;issue=6;spage=1600;epage=1614;aulast=Alkandari |
| _version_ | 1811342247418920960 |
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| author | Omar Alkandari Alanoud A. Alshami Entesar A. Alhammadi |
| author_facet | Omar Alkandari Alanoud A. Alshami Entesar A. Alhammadi |
| author_sort | Omar Alkandari |
| collection | DOAJ |
| description | Childhood nephrotic syndrome (NS) management is greatly variable among pediatric nephrologists worldwide. We aimed to evaluate if this variability exists among pediatric nephrologists in the gulf countries and whether certain training programs influence this variability. A web-based multiple-choice survey of 35 NS management questions distributed to certified pediatric nephrologists working in the Gulf countries. Amongst 92 invitees, the response rate was 67%. The majority (73%) were older than 50 years and male (58%). Sixty percent trained in North America and 41% had >10 years of experience. Sixty-three percent use a 12- week corticosteroids regimen for the initial treatment of childhood NS and only 10% never consider long-term small alternate dose corticosteroids therapy to sustain remission before commencing a corticosteroids-sparing agent for frequently relapsing or corticosteroids-dependent NS. Mycophenolate mofetil was the drug of choice for frequently relapsing and corticosteroids dependent NS in 51% and 58% of the participants, respectively, whereas calcineurin inhibitors were preferred by the vast majority (95%) of the participants for corticosteroids-resistant childhood NS. Regarding rituximab treatment, almost half of the participants (48%) give two doses of rituximab one to two weeks apart and 61% do not give another course of rituximab until the child relapse. Fellowship training site and the duration of the clinical experience did not seem to influence certain management of childhood NS. As shown in North American studies, great variability in the management of childhood NS does exist in the Gulf countries. The country of fellowship training and the experience did not seem to contribute to this variability. |
| first_indexed | 2024-04-13T19:08:17Z |
| format | Article |
| id | doaj.art-98dad193b92d4882bbefd02b75707296 |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-04-13T19:08:17Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-98dad193b92d4882bbefd02b757072962022-12-22T02:33:55ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422021-01-013261600161410.4103/1319-2442.352421Practice of Childhood Nephrotic Syndrome Management amongPediatric Nephrologists in the GCC CountriesOmar AlkandariAlanoud A. AlshamiEntesar A. AlhammadiChildhood nephrotic syndrome (NS) management is greatly variable among pediatric nephrologists worldwide. We aimed to evaluate if this variability exists among pediatric nephrologists in the gulf countries and whether certain training programs influence this variability. A web-based multiple-choice survey of 35 NS management questions distributed to certified pediatric nephrologists working in the Gulf countries. Amongst 92 invitees, the response rate was 67%. The majority (73%) were older than 50 years and male (58%). Sixty percent trained in North America and 41% had >10 years of experience. Sixty-three percent use a 12- week corticosteroids regimen for the initial treatment of childhood NS and only 10% never consider long-term small alternate dose corticosteroids therapy to sustain remission before commencing a corticosteroids-sparing agent for frequently relapsing or corticosteroids-dependent NS. Mycophenolate mofetil was the drug of choice for frequently relapsing and corticosteroids dependent NS in 51% and 58% of the participants, respectively, whereas calcineurin inhibitors were preferred by the vast majority (95%) of the participants for corticosteroids-resistant childhood NS. Regarding rituximab treatment, almost half of the participants (48%) give two doses of rituximab one to two weeks apart and 61% do not give another course of rituximab until the child relapse. Fellowship training site and the duration of the clinical experience did not seem to influence certain management of childhood NS. As shown in North American studies, great variability in the management of childhood NS does exist in the Gulf countries. The country of fellowship training and the experience did not seem to contribute to this variability.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2021;volume=32;issue=6;spage=1600;epage=1614;aulast=Alkandari |
| spellingShingle | Omar Alkandari Alanoud A. Alshami Entesar A. Alhammadi Practice of Childhood Nephrotic Syndrome Management amongPediatric Nephrologists in the GCC Countries Saudi Journal of Kidney Diseases and Transplantation |
| title | Practice of Childhood Nephrotic Syndrome Management amongPediatric Nephrologists in the GCC Countries |
| title_full | Practice of Childhood Nephrotic Syndrome Management amongPediatric Nephrologists in the GCC Countries |
| title_fullStr | Practice of Childhood Nephrotic Syndrome Management amongPediatric Nephrologists in the GCC Countries |
| title_full_unstemmed | Practice of Childhood Nephrotic Syndrome Management amongPediatric Nephrologists in the GCC Countries |
| title_short | Practice of Childhood Nephrotic Syndrome Management amongPediatric Nephrologists in the GCC Countries |
| title_sort | practice of childhood nephrotic syndrome management amongpediatric nephrologists in the gcc countries |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2021;volume=32;issue=6;spage=1600;epage=1614;aulast=Alkandari |
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