Interaction of gut microbiota with the tumor microenvironment: A new strategy for antitumor treatment and traditional Chinese medicine in colorectal cancer
Colorectal cancer (CRC) is one of the most common malignancies worldwide and the second leading cause of cancer-related death. In recent years, the relationship between gut microbiota and CRC has attracted increasing attention from researchers. Studies reported that changes in the composition of gut...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1140325/full |
| _version_ | 1811159566436532224 |
|---|---|
| author | Tingting Li Liang Han Simin Ma Weiji Lin Xin Ba Jiahui Yan Ying Huang Shenghao Tu Kai Qin |
| author_facet | Tingting Li Liang Han Simin Ma Weiji Lin Xin Ba Jiahui Yan Ying Huang Shenghao Tu Kai Qin |
| author_sort | Tingting Li |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the most common malignancies worldwide and the second leading cause of cancer-related death. In recent years, the relationship between gut microbiota and CRC has attracted increasing attention from researchers. Studies reported that changes in the composition of gut microbiota, such as increase in the number of Fusobacterium nucleatum and Helicobacter hepaticus, impair the immune surveillance by affecting the intestinal mucosal immunity and increase the risk of tumor initiation and progression. The tumor microenvironment is the soil for tumor survival. Close contacts between gut microbiota and the tumor microenvironment may directly affect the progression of tumors and efficacy of antitumor drugs, thus influencing the prognosis of patients with CRC. Recently, many studies have shown that traditional Chinese medicine can safely and effectively improve the efficacy of antitumor drugs, potentially through remodeling of the tumor microenvironment by regulated gut microbiota. This article describes the effect of gut microbiota on the tumor microenvironment and possible mechanisms concerning the initiation and progression of CRC, and summarizes the potential role of traditional Chinese medicine. |
| first_indexed | 2024-04-10T05:43:21Z |
| format | Article |
| id | doaj.art-98db32b7e79c44ba9345223d1322e0af |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-10T05:43:21Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-98db32b7e79c44ba9345223d1322e0af2023-03-06T06:41:43ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-03-011010.3389/fmolb.2023.11403251140325Interaction of gut microbiota with the tumor microenvironment: A new strategy for antitumor treatment and traditional Chinese medicine in colorectal cancerTingting Li0Liang Han1Simin Ma2Weiji Lin3Xin Ba4Jiahui Yan5Ying Huang6Shenghao Tu7Kai Qin8Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Nosocomial Infection Management, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaColorectal cancer (CRC) is one of the most common malignancies worldwide and the second leading cause of cancer-related death. In recent years, the relationship between gut microbiota and CRC has attracted increasing attention from researchers. Studies reported that changes in the composition of gut microbiota, such as increase in the number of Fusobacterium nucleatum and Helicobacter hepaticus, impair the immune surveillance by affecting the intestinal mucosal immunity and increase the risk of tumor initiation and progression. The tumor microenvironment is the soil for tumor survival. Close contacts between gut microbiota and the tumor microenvironment may directly affect the progression of tumors and efficacy of antitumor drugs, thus influencing the prognosis of patients with CRC. Recently, many studies have shown that traditional Chinese medicine can safely and effectively improve the efficacy of antitumor drugs, potentially through remodeling of the tumor microenvironment by regulated gut microbiota. This article describes the effect of gut microbiota on the tumor microenvironment and possible mechanisms concerning the initiation and progression of CRC, and summarizes the potential role of traditional Chinese medicine.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1140325/fullcolorectal cancertumor microenvironmentgut microbiotatraditional Chinese medicinetreatment |
| spellingShingle | Tingting Li Liang Han Simin Ma Weiji Lin Xin Ba Jiahui Yan Ying Huang Shenghao Tu Kai Qin Interaction of gut microbiota with the tumor microenvironment: A new strategy for antitumor treatment and traditional Chinese medicine in colorectal cancer Frontiers in Molecular Biosciences colorectal cancer tumor microenvironment gut microbiota traditional Chinese medicine treatment |
| title | Interaction of gut microbiota with the tumor microenvironment: A new strategy for antitumor treatment and traditional Chinese medicine in colorectal cancer |
| title_full | Interaction of gut microbiota with the tumor microenvironment: A new strategy for antitumor treatment and traditional Chinese medicine in colorectal cancer |
| title_fullStr | Interaction of gut microbiota with the tumor microenvironment: A new strategy for antitumor treatment and traditional Chinese medicine in colorectal cancer |
| title_full_unstemmed | Interaction of gut microbiota with the tumor microenvironment: A new strategy for antitumor treatment and traditional Chinese medicine in colorectal cancer |
| title_short | Interaction of gut microbiota with the tumor microenvironment: A new strategy for antitumor treatment and traditional Chinese medicine in colorectal cancer |
| title_sort | interaction of gut microbiota with the tumor microenvironment a new strategy for antitumor treatment and traditional chinese medicine in colorectal cancer |
| topic | colorectal cancer tumor microenvironment gut microbiota traditional Chinese medicine treatment |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1140325/full |
| work_keys_str_mv | AT tingtingli interactionofgutmicrobiotawiththetumormicroenvironmentanewstrategyforantitumortreatmentandtraditionalchinesemedicineincolorectalcancer AT lianghan interactionofgutmicrobiotawiththetumormicroenvironmentanewstrategyforantitumortreatmentandtraditionalchinesemedicineincolorectalcancer AT siminma interactionofgutmicrobiotawiththetumormicroenvironmentanewstrategyforantitumortreatmentandtraditionalchinesemedicineincolorectalcancer AT weijilin interactionofgutmicrobiotawiththetumormicroenvironmentanewstrategyforantitumortreatmentandtraditionalchinesemedicineincolorectalcancer AT xinba interactionofgutmicrobiotawiththetumormicroenvironmentanewstrategyforantitumortreatmentandtraditionalchinesemedicineincolorectalcancer AT jiahuiyan interactionofgutmicrobiotawiththetumormicroenvironmentanewstrategyforantitumortreatmentandtraditionalchinesemedicineincolorectalcancer AT yinghuang interactionofgutmicrobiotawiththetumormicroenvironmentanewstrategyforantitumortreatmentandtraditionalchinesemedicineincolorectalcancer AT shenghaotu interactionofgutmicrobiotawiththetumormicroenvironmentanewstrategyforantitumortreatmentandtraditionalchinesemedicineincolorectalcancer AT kaiqin interactionofgutmicrobiotawiththetumormicroenvironmentanewstrategyforantitumortreatmentandtraditionalchinesemedicineincolorectalcancer |