Ignored and undervalued in public health: a systematic review of health state utility values associated with syphilis infection
Abstract Background Syphilis is a sexually transmitted infection causing significant global morbidity and mortality. To inform policymaking and economic evaluation studies for syphilis, we summarised utility and disability weights for health states associated with syphilis. Methods We conducted a sy...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Health and Quality of Life Outcomes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12955-024-02234-1 |
| _version_ | 1797273186143830016 |
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| author | Patrick Miao Fern Terris-Prestholt Christopher K. Fairley Joseph D. Tucker Virginia Wiseman Philippe Mayaud Ying Zhang Jane Rowley Sami Gottlieb Eline L. Korenromp Caroline G. Watts Jason J. Ong |
| author_facet | Patrick Miao Fern Terris-Prestholt Christopher K. Fairley Joseph D. Tucker Virginia Wiseman Philippe Mayaud Ying Zhang Jane Rowley Sami Gottlieb Eline L. Korenromp Caroline G. Watts Jason J. Ong |
| author_sort | Patrick Miao |
| collection | DOAJ |
| description | Abstract Background Syphilis is a sexually transmitted infection causing significant global morbidity and mortality. To inform policymaking and economic evaluation studies for syphilis, we summarised utility and disability weights for health states associated with syphilis. Methods We conducted a systematic review, searching six databases for economic evaluations and primary valuation studies related to syphilis from January 2000 to February 2022. We extracted health state utility values or disability weights, including identification of how these were derived. The study was registered in the international prospective register of systematic reviews (PROSPERO, CRD42021230035). Findings Of 3401 studies screened, 22 economic evaluations, two primary studies providing condition-specific measures, and 13 burden of disease studies were included. Fifteen economic evaluations reported outcomes as disability-adjusted life years (DALYs) and seven reported quality-adjusted life years (QALYs). Fourteen of 15 economic evaluations that used DALYS based their values on the original Global Burden of Disease (GBD) study from 1990 (published in 1996). For the seven QALY-related economic evaluations, the methodology varied between studies, with some studies using assumptions and others creating utility weights or converting them from disability weights. Interpretation We found a limited evidence base for the valuation of health states for syphilis, a lack of transparency for the development of existing health state utility values, and inconsistencies in the application of these values to estimate DALYs and QALYs. Further research is required to expand the evidence base so that policymakers can access accurate and well-informed economic evaluations to allocate resources to address syphilis and implement syphilis programs that are cost-effective. |
| first_indexed | 2024-03-07T14:39:56Z |
| format | Article |
| id | doaj.art-98dc9736ee7344fdafeb01e78cd27e47 |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-03-07T14:39:56Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-98dc9736ee7344fdafeb01e78cd27e472024-03-05T20:26:09ZengBMCHealth and Quality of Life Outcomes1477-75252024-02-0122112110.1186/s12955-024-02234-1Ignored and undervalued in public health: a systematic review of health state utility values associated with syphilis infectionPatrick Miao0Fern Terris-Prestholt1Christopher K. Fairley2Joseph D. Tucker3Virginia Wiseman4Philippe Mayaud5Ying Zhang6Jane Rowley7Sami Gottlieb8Eline L. Korenromp9Caroline G. Watts10Jason J. Ong11Central Clinical School, Monash UniversityDepartment of Global Health and Development, London School of Hygiene and Tropical MedicineCentral Clinical School, Monash UniversityFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical MedicineDepartment of Global Health and Development, London School of Hygiene and Tropical MedicineFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical MedicineCentral Clinical School, Monash UniversityGlobal HIV, Hepatitis and Sexual Transmitted Infections Programme, World Health OrganizationDepartment of Sexual and Reproductive Health and Research, World Health OrganizationUNAIDSKirby Institute, University of New South WalesCentral Clinical School, Monash UniversityAbstract Background Syphilis is a sexually transmitted infection causing significant global morbidity and mortality. To inform policymaking and economic evaluation studies for syphilis, we summarised utility and disability weights for health states associated with syphilis. Methods We conducted a systematic review, searching six databases for economic evaluations and primary valuation studies related to syphilis from January 2000 to February 2022. We extracted health state utility values or disability weights, including identification of how these were derived. The study was registered in the international prospective register of systematic reviews (PROSPERO, CRD42021230035). Findings Of 3401 studies screened, 22 economic evaluations, two primary studies providing condition-specific measures, and 13 burden of disease studies were included. Fifteen economic evaluations reported outcomes as disability-adjusted life years (DALYs) and seven reported quality-adjusted life years (QALYs). Fourteen of 15 economic evaluations that used DALYS based their values on the original Global Burden of Disease (GBD) study from 1990 (published in 1996). For the seven QALY-related economic evaluations, the methodology varied between studies, with some studies using assumptions and others creating utility weights or converting them from disability weights. Interpretation We found a limited evidence base for the valuation of health states for syphilis, a lack of transparency for the development of existing health state utility values, and inconsistencies in the application of these values to estimate DALYs and QALYs. Further research is required to expand the evidence base so that policymakers can access accurate and well-informed economic evaluations to allocate resources to address syphilis and implement syphilis programs that are cost-effective.https://doi.org/10.1186/s12955-024-02234-1SyphilisHealth economicsQuality of lifeHealth state utility valueUtility weightDisability weight |
| spellingShingle | Patrick Miao Fern Terris-Prestholt Christopher K. Fairley Joseph D. Tucker Virginia Wiseman Philippe Mayaud Ying Zhang Jane Rowley Sami Gottlieb Eline L. Korenromp Caroline G. Watts Jason J. Ong Ignored and undervalued in public health: a systematic review of health state utility values associated with syphilis infection Health and Quality of Life Outcomes Syphilis Health economics Quality of life Health state utility value Utility weight Disability weight |
| title | Ignored and undervalued in public health: a systematic review of health state utility values associated with syphilis infection |
| title_full | Ignored and undervalued in public health: a systematic review of health state utility values associated with syphilis infection |
| title_fullStr | Ignored and undervalued in public health: a systematic review of health state utility values associated with syphilis infection |
| title_full_unstemmed | Ignored and undervalued in public health: a systematic review of health state utility values associated with syphilis infection |
| title_short | Ignored and undervalued in public health: a systematic review of health state utility values associated with syphilis infection |
| title_sort | ignored and undervalued in public health a systematic review of health state utility values associated with syphilis infection |
| topic | Syphilis Health economics Quality of life Health state utility value Utility weight Disability weight |
| url | https://doi.org/10.1186/s12955-024-02234-1 |
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