Substances of Natural Origin in Medicine: Plants vs. Cancer
Continuous monitoring of the population’s health is the main method of learning about disease prevalence. National and international data draw attention to the persistently high rates of cancer incidence. This necessitates the intensification of efforts aimed at developing new, more effective chemot...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/7/986 |
| _version_ | 1797608198824263680 |
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| author | Adrianna Gielecińska Mateusz Kciuk Somdutt Mujwar Ismail Celik Damian Kołat Żaneta Kałuzińska-Kołat Renata Kontek |
| author_facet | Adrianna Gielecińska Mateusz Kciuk Somdutt Mujwar Ismail Celik Damian Kołat Żaneta Kałuzińska-Kołat Renata Kontek |
| author_sort | Adrianna Gielecińska |
| collection | DOAJ |
| description | Continuous monitoring of the population’s health is the main method of learning about disease prevalence. National and international data draw attention to the persistently high rates of cancer incidence. This necessitates the intensification of efforts aimed at developing new, more effective chemotherapeutic and chemopreventive drugs. Plants represent an invaluable source of natural substances with versatile medicinal properties. Multidirectional activities exhibited by natural substances and their ability to modulate key signaling pathways, mainly related to cancer cell death, make these substances an important research direction. This review summarizes the information regarding plant-derived chemotherapeutic drugs, including their mechanisms of action, with a special focus on selected anti-cancer drugs (paclitaxel, irinotecan) approved in clinical practice. It also presents promising plant-based drug candidates currently being tested in clinical and preclinical trials (betulinic acid, resveratrol, and roburic acid). |
| first_indexed | 2024-03-11T05:41:06Z |
| format | Article |
| id | doaj.art-98dcf7be0bc34e05903a5e7ae8261dce |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T05:41:06Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-98dcf7be0bc34e05903a5e7ae8261dce2023-11-17T16:27:40ZengMDPI AGCells2073-44092023-03-0112798610.3390/cells12070986Substances of Natural Origin in Medicine: Plants vs. CancerAdrianna Gielecińska0Mateusz Kciuk1Somdutt Mujwar2Ismail Celik3Damian Kołat4Żaneta Kałuzińska-Kołat5Renata Kontek6Doctoral School of Exact and Natural Sciences, University of Lodz, 90-237 Lodz, PolandDoctoral School of Exact and Natural Sciences, University of Lodz, 90-237 Lodz, PolandChitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, IndiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38039, TurkeyDepartment of Experimental Surgery, Faculty of Medicine, Medical University of Lodz, Narutowicza 60, 90-136 Lodz, PolandDepartment of Experimental Surgery, Faculty of Medicine, Medical University of Lodz, Narutowicza 60, 90-136 Lodz, PolandDepartment of Molecular Biotechnology and Genetics, University of Lodz, 90-237 Lodz, PolandContinuous monitoring of the population’s health is the main method of learning about disease prevalence. National and international data draw attention to the persistently high rates of cancer incidence. This necessitates the intensification of efforts aimed at developing new, more effective chemotherapeutic and chemopreventive drugs. Plants represent an invaluable source of natural substances with versatile medicinal properties. Multidirectional activities exhibited by natural substances and their ability to modulate key signaling pathways, mainly related to cancer cell death, make these substances an important research direction. This review summarizes the information regarding plant-derived chemotherapeutic drugs, including their mechanisms of action, with a special focus on selected anti-cancer drugs (paclitaxel, irinotecan) approved in clinical practice. It also presents promising plant-based drug candidates currently being tested in clinical and preclinical trials (betulinic acid, resveratrol, and roburic acid).https://www.mdpi.com/2073-4409/12/7/986cancerpaclitaxelirinotecanbetulinic acidresveratrolroburic acid |
| spellingShingle | Adrianna Gielecińska Mateusz Kciuk Somdutt Mujwar Ismail Celik Damian Kołat Żaneta Kałuzińska-Kołat Renata Kontek Substances of Natural Origin in Medicine: Plants vs. Cancer Cells cancer paclitaxel irinotecan betulinic acid resveratrol roburic acid |
| title | Substances of Natural Origin in Medicine: Plants vs. Cancer |
| title_full | Substances of Natural Origin in Medicine: Plants vs. Cancer |
| title_fullStr | Substances of Natural Origin in Medicine: Plants vs. Cancer |
| title_full_unstemmed | Substances of Natural Origin in Medicine: Plants vs. Cancer |
| title_short | Substances of Natural Origin in Medicine: Plants vs. Cancer |
| title_sort | substances of natural origin in medicine plants vs cancer |
| topic | cancer paclitaxel irinotecan betulinic acid resveratrol roburic acid |
| url | https://www.mdpi.com/2073-4409/12/7/986 |
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