Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague–Dawley rats
Low-frequency stimulation (LFS) of the kindling focus or the piriform cortex inhibits kindling epileptogenesis, but whether LFS of brain targets outside the limbic system has anticonvulsive actions remain unknown. The current study was designed to investigate the effect of LFS of the cerebellar fast...
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Elsevier
2008-01-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996107001842 |
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| author | Shuang Wang Deng-chang Wu Mei-ping Ding Qing Li Zhen-bing Zhuge Shi-hong Zhang Zhong Chen |
| author_facet | Shuang Wang Deng-chang Wu Mei-ping Ding Qing Li Zhen-bing Zhuge Shi-hong Zhang Zhong Chen |
| author_sort | Shuang Wang |
| collection | DOAJ |
| description | Low-frequency stimulation (LFS) of the kindling focus or the piriform cortex inhibits kindling epileptogenesis, but whether LFS of brain targets outside the limbic system has anticonvulsive actions remain unknown. The current study was designed to investigate the effect of LFS of the cerebellar fastigial nucleus (FN) on seizure progression induced by amygdaloid kindling. Stimulation at 1 Hz (15-min train of 0.1-ms pulses, 100 μA), but not at 3 Hz, in the ipsilateral FN immediately after the daily kindling stimulus (1-s train of 1-ms pulses at 60 Hz and 100–300 μA) significantly inhibited the seizure stage and afterdischarge duration in kindling acquisition. Neither 1 Hz nor 3 Hz stimulation of the contralateral FH had any significant effect. It is interesting that delaying delivery (immediately after the cessation of afterdischarge) of LFS in the ipsilateral FN accelerated the rate of kindling acquisition compared to controls. Our study suggests that LFS of targets outside the limbic system, such as the FN, may have a significant anti-epileptogenic action, and the effects of LFS depend on the frequency and timing of stimulation. |
| first_indexed | 2024-12-16T16:46:08Z |
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| id | doaj.art-98dd979f33844f42bb0ed013ee5acb9a |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-16T16:46:08Z |
| publishDate | 2008-01-01 |
| publisher | Elsevier |
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| series | Neurobiology of Disease |
| spelling | doaj.art-98dd979f33844f42bb0ed013ee5acb9a2022-12-21T22:24:11ZengElsevierNeurobiology of Disease1095-953X2008-01-012915258Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague–Dawley ratsShuang Wang0Deng-chang Wu1Mei-ping Ding2Qing Li3Zhen-bing Zhuge4Shi-hong Zhang5Zhong Chen6Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 310058 China; Department of Neurology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009 ChinaDepartment of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 310058 ChinaDepartment of Neurology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009 ChinaDepartment of Physiology, Zhejiang Medical College, Hangzhou, 310053 ChinaDepartment of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 310058 ChinaDepartment of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 310058 ChinaDepartment of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 310058 China; Corresponding author. Fax: +86 571 88208228.Low-frequency stimulation (LFS) of the kindling focus or the piriform cortex inhibits kindling epileptogenesis, but whether LFS of brain targets outside the limbic system has anticonvulsive actions remain unknown. The current study was designed to investigate the effect of LFS of the cerebellar fastigial nucleus (FN) on seizure progression induced by amygdaloid kindling. Stimulation at 1 Hz (15-min train of 0.1-ms pulses, 100 μA), but not at 3 Hz, in the ipsilateral FN immediately after the daily kindling stimulus (1-s train of 1-ms pulses at 60 Hz and 100–300 μA) significantly inhibited the seizure stage and afterdischarge duration in kindling acquisition. Neither 1 Hz nor 3 Hz stimulation of the contralateral FH had any significant effect. It is interesting that delaying delivery (immediately after the cessation of afterdischarge) of LFS in the ipsilateral FN accelerated the rate of kindling acquisition compared to controls. Our study suggests that LFS of targets outside the limbic system, such as the FN, may have a significant anti-epileptogenic action, and the effects of LFS depend on the frequency and timing of stimulation.http://www.sciencedirect.com/science/article/pii/S0969996107001842EpilepsyBrain stimulationKindled seizuresFastigial nuclei |
| spellingShingle | Shuang Wang Deng-chang Wu Mei-ping Ding Qing Li Zhen-bing Zhuge Shi-hong Zhang Zhong Chen Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague–Dawley rats Neurobiology of Disease Epilepsy Brain stimulation Kindled seizures Fastigial nuclei |
| title | Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague–Dawley rats |
| title_full | Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague–Dawley rats |
| title_fullStr | Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague–Dawley rats |
| title_full_unstemmed | Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague–Dawley rats |
| title_short | Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague–Dawley rats |
| title_sort | low frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in sprague dawley rats |
| topic | Epilepsy Brain stimulation Kindled seizures Fastigial nuclei |
| url | http://www.sciencedirect.com/science/article/pii/S0969996107001842 |
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