Transcriptome analysis of immune cells from Behçet’s syndrome patients: the importance of IL-17-producing cells and antigen-presenting cells in the pathogenesis of Behçet’s syndrome

Transcriptome analysis of immune cells from Behçet’s syndrome patients: the importance of IL-17-producing cells and antigen-presenting cells in the pathogenesis of Behçet’s syndrome

Abstract Background Behçet’s syndrome (BS) is an immune-mediated disease characterized by recurrent oral ulcers, genital ulcers, uveitis, and skin symptoms. HLA-B51, as well as other genetic polymorphisms, has been reported to be associated with BS; however, the pathogenesis of BS and its relationsh...

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Main Authors: Mai Okubo, Shuji Sumitomo, Yumi Tsuchida, Yasuo Nagafuchi, Yusuke Takeshima, Haruyuki Yanaoka, Harumi Shirai, Satomi Kobayashi, Yusuke Sugimori, Junko Maeda, Hiroaki Hatano, Yukiko Iwasaki, Hirofumi Shoda, Tomohisa Okamura, Kazuhiko Yamamoto, Mineto Ota, Keishi Fujio
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Arthritis Research & Therapy
Subjects:
Behçet’s syndrome
Transcriptome
Interleukin-17
YBX3
Antigen-presenting cells
Online Access:https://doi.org/10.1186/s13075-022-02867-x

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