Tumor Metabolism of Malignant Gliomas
Constitutively activated oncogenic signaling via genetic mutations such as in the EGFR/PI3K/Akt and Ras/RAF/MEK pathways has been recognized as a major driver for tumorigenesis in most cancers. Recent insights into tumor metabolism have further revealed that oncogenic signaling pathways directly pro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/5/4/1469 |
| _version_ | 1797713570919612416 |
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| author | Deliang Guo Arnab Chakravarti Terence M. Williams Peng Ru |
| author_facet | Deliang Guo Arnab Chakravarti Terence M. Williams Peng Ru |
| author_sort | Deliang Guo |
| collection | DOAJ |
| description | Constitutively activated oncogenic signaling via genetic mutations such as in the EGFR/PI3K/Akt and Ras/RAF/MEK pathways has been recognized as a major driver for tumorigenesis in most cancers. Recent insights into tumor metabolism have further revealed that oncogenic signaling pathways directly promote metabolic reprogramming to upregulate biosynthesis of lipids, carbohydrates, protein, DNA and RNA, leading to enhanced growth of human tumors. Therefore, targeting cell metabolism has become a novel direction for drug development in oncology. In malignant gliomas, metabolism pathways of glucose, glutamine and lipid are significantly reprogrammed. Moreover, molecular mechanisms causing these metabolic changes are just starting to be unraveled. In this review, we will summarize recent studies revealing critical gene alterations that lead to metabolic changes in malignant gliomas, and also discuss promising therapeutic strategies via targeting the key players in metabolic regulation. |
| first_indexed | 2024-03-12T07:38:35Z |
| format | Article |
| id | doaj.art-98e17817c45a42bcb76858e08652ef05 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T07:38:35Z |
| publishDate | 2013-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-98e17817c45a42bcb76858e08652ef052023-09-02T21:25:47ZengMDPI AGCancers2072-66942013-11-01541469148410.3390/cancers5041469Tumor Metabolism of Malignant GliomasDeliang GuoArnab ChakravartiTerence M. WilliamsPeng RuConstitutively activated oncogenic signaling via genetic mutations such as in the EGFR/PI3K/Akt and Ras/RAF/MEK pathways has been recognized as a major driver for tumorigenesis in most cancers. Recent insights into tumor metabolism have further revealed that oncogenic signaling pathways directly promote metabolic reprogramming to upregulate biosynthesis of lipids, carbohydrates, protein, DNA and RNA, leading to enhanced growth of human tumors. Therefore, targeting cell metabolism has become a novel direction for drug development in oncology. In malignant gliomas, metabolism pathways of glucose, glutamine and lipid are significantly reprogrammed. Moreover, molecular mechanisms causing these metabolic changes are just starting to be unraveled. In this review, we will summarize recent studies revealing critical gene alterations that lead to metabolic changes in malignant gliomas, and also discuss promising therapeutic strategies via targeting the key players in metabolic regulation.http://www.mdpi.com/2072-6694/5/4/1469glioblastomatumor metabolismSREBP-1LDLRLXRglucoselipidscholesterol |
| spellingShingle | Deliang Guo Arnab Chakravarti Terence M. Williams Peng Ru Tumor Metabolism of Malignant Gliomas Cancers glioblastoma tumor metabolism SREBP-1 LDLR LXR glucose lipids cholesterol |
| title | Tumor Metabolism of Malignant Gliomas |
| title_full | Tumor Metabolism of Malignant Gliomas |
| title_fullStr | Tumor Metabolism of Malignant Gliomas |
| title_full_unstemmed | Tumor Metabolism of Malignant Gliomas |
| title_short | Tumor Metabolism of Malignant Gliomas |
| title_sort | tumor metabolism of malignant gliomas |
| topic | glioblastoma tumor metabolism SREBP-1 LDLR LXR glucose lipids cholesterol |
| url | http://www.mdpi.com/2072-6694/5/4/1469 |
| work_keys_str_mv | AT deliangguo tumormetabolismofmalignantgliomas AT arnabchakravarti tumormetabolismofmalignantgliomas AT terencemwilliams tumormetabolismofmalignantgliomas AT pengru tumormetabolismofmalignantgliomas |