ADAM10-Mediated Cleavage of ICAM-1 Is Involved in Neutrophil Transendothelial Migration

ADAM10-Mediated Cleavage of ICAM-1 Is Involved in Neutrophil Transendothelial Migration

To efficiently cross the endothelial barrier during inflammation, neutrophils first firmly adhere to the endothelial surface using the endothelial adhesion molecule ICAM-1. Upon actual transmigration, the release from ICAM-1 is required. While Integrin LFA1/Mac1 de-activation is one described mechan...

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Bibliographic Details
Main Authors: Sofia K. H. Morsing, Timo Rademakers, Sanne L. N. Brouns, Anne-Marieke D. van Stalborch, Marjo M. P. C. Donners, Jaap D. van Buul
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
transmigration
ICAM-1
endothelium
ADAM
shedding
Online Access:https://www.mdpi.com/2073-4409/10/2/232

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