Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling

Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling

Diabetes and inflammatory diseases are associated with an altered cellular lipid composition due to lipid peroxidation. The pathogenic potential of these lipid alterations in glomerular kidney diseases remains largely obscure as suitable cell culture and animal models are lacking. In glomerular dise...

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Bibliographic Details
Main Authors: Henning Hagmann, Naghmeh Hassanzadeh Khayyat, Cem Oezel, Antonios Papadakis, Alexander Kuczkowski, Thomas Benzing, Erich Gulbins, Stuart Dryer, Paul T. Brinkkoetter
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
podocyte
calcium signaling
oxidative stress
lipid peroxidation
Online Access:https://www.mdpi.com/2073-4409/11/22/3625

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