BIOACTIVE COMPOUNDS IN BENGKOANG (Pachyrhizus erosus) AS ANTIOXIDANT AND TYROSINASE INHIBITING AGENTS
In Indonesia, the roots of bengkoang (Phacyrhizus erosus) have been used as the excipient for sun screening and skin whitening paste. Since the active compounds exhibiting skin whitening or sun screening effect have not previously been studied, the aim of this study was to identify compounds wit...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Gadjah Mada
2014-04-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/11 |
| _version_ | 1811222125975961600 |
|---|---|
| author | Endang Lukitaningsih Ulrike Holzgrabe |
| author_facet | Endang Lukitaningsih Ulrike Holzgrabe |
| author_sort | Endang Lukitaningsih |
| collection | DOAJ |
| description | In Indonesia, the roots of bengkoang (Phacyrhizus erosus)
have been used as the excipient for sun screening and skin
whitening paste. Since the active compounds exhibiting skin
whitening or sun screening effect have not previously been
studied, the aim of this study was to identify compounds with
antioxidant and tyrosinase inhibitor activities. Soxhlet extraction
was used as the method of isolation with petroleum ether as the
solvent and it was followed by fractionation using ethyl acetate
to obtain three isoflavonoids (i.e. daidzein (2); daidzein-7-O-ßglucopyranose
(3); 5-hydroxy-daidzein-7-O-ß-glucopyranose
(4)), and a new pterocarpan (i. e. 8,9-furanyl-pterocarpan-3-ol
(1)) which antioxidant activities (SC50% values) of 2.11; 11.86;
0.69 and 7.86 respectively. All compounds showed tyrosinase
inhibiting activities with IC50 values of 4.38; 5.35; 7.49 and
22.20 mM, respectively for compound 4, 2, 1 and 3. These
compounds can be used as antioxidant and skin whitening
materials. |
| first_indexed | 2024-04-12T08:11:23Z |
| format | Article |
| id | doaj.art-98e99c22e78241478af56d49e537816d |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-04-12T08:11:23Z |
| publishDate | 2014-04-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-98e99c22e78241478af56d49e537816d2022-12-22T03:40:58ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862014-04-01252687510.14499/indonesianjpharm25iss2pp75BIOACTIVE COMPOUNDS IN BENGKOANG (Pachyrhizus erosus) AS ANTIOXIDANT AND TYROSINASE INHIBITING AGENTSEndang Lukitaningsih0Ulrike Holzgrabe1Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Bulaksumur, Yogyakarta 55281, Indonesia Dept of Pharmacy and Food Chemistry, Würzburg University, Am Hubland, 97074, Würzburg, GermanyIn Indonesia, the roots of bengkoang (Phacyrhizus erosus) have been used as the excipient for sun screening and skin whitening paste. Since the active compounds exhibiting skin whitening or sun screening effect have not previously been studied, the aim of this study was to identify compounds with antioxidant and tyrosinase inhibitor activities. Soxhlet extraction was used as the method of isolation with petroleum ether as the solvent and it was followed by fractionation using ethyl acetate to obtain three isoflavonoids (i.e. daidzein (2); daidzein-7-O-ßglucopyranose (3); 5-hydroxy-daidzein-7-O-ß-glucopyranose (4)), and a new pterocarpan (i. e. 8,9-furanyl-pterocarpan-3-ol (1)) which antioxidant activities (SC50% values) of 2.11; 11.86; 0.69 and 7.86 respectively. All compounds showed tyrosinase inhibiting activities with IC50 values of 4.38; 5.35; 7.49 and 22.20 mM, respectively for compound 4, 2, 1 and 3. These compounds can be used as antioxidant and skin whitening materials.http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/11Pachyrhizus erosusantioxidanttyrosinase inhibitorflavonoids |
| spellingShingle | Endang Lukitaningsih Ulrike Holzgrabe BIOACTIVE COMPOUNDS IN BENGKOANG (Pachyrhizus erosus) AS ANTIOXIDANT AND TYROSINASE INHIBITING AGENTS Indonesian Journal of Pharmacy Pachyrhizus erosus antioxidant tyrosinase inhibitor flavonoids |
| title | BIOACTIVE COMPOUNDS IN BENGKOANG (Pachyrhizus erosus) AS ANTIOXIDANT AND TYROSINASE INHIBITING AGENTS |
| title_full | BIOACTIVE COMPOUNDS IN BENGKOANG (Pachyrhizus erosus) AS ANTIOXIDANT AND TYROSINASE INHIBITING AGENTS |
| title_fullStr | BIOACTIVE COMPOUNDS IN BENGKOANG (Pachyrhizus erosus) AS ANTIOXIDANT AND TYROSINASE INHIBITING AGENTS |
| title_full_unstemmed | BIOACTIVE COMPOUNDS IN BENGKOANG (Pachyrhizus erosus) AS ANTIOXIDANT AND TYROSINASE INHIBITING AGENTS |
| title_short | BIOACTIVE COMPOUNDS IN BENGKOANG (Pachyrhizus erosus) AS ANTIOXIDANT AND TYROSINASE INHIBITING AGENTS |
| title_sort | bioactive compounds in bengkoang pachyrhizus erosus as antioxidant and tyrosinase inhibiting agents |
| topic | Pachyrhizus erosus antioxidant tyrosinase inhibitor flavonoids |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/11 |
| work_keys_str_mv | AT endanglukitaningsih bioactivecompoundsinbengkoangpachyrhizuserosusasantioxidantandtyrosinaseinhibitingagents AT ulrikeholzgrabe bioactivecompoundsinbengkoangpachyrhizuserosusasantioxidantandtyrosinaseinhibitingagents |