Clinical and pathological characteristics of early-onset colorectal cancer in South Korea
Background: Early-onset colorectal cancer (EOCRC) may differ by race and ethnicity, and recently South Korea has witnessed a surge in cases. We aimed to evaluate the clinical and pathological features of patients with EOCRC, and to determine the predictors of overall survival. Methods: In this retro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2023;volume=29;issue=6;spage=358;epage=364;aulast=Park |
| _version_ | 1797226234758823936 |
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| author | Su Bee Park Jin Young Yoon Min Seob Kwak Jae Myung Cha |
| author_facet | Su Bee Park Jin Young Yoon Min Seob Kwak Jae Myung Cha |
| author_sort | Su Bee Park |
| collection | DOAJ |
| description | Background: Early-onset colorectal cancer (EOCRC) may differ by race and ethnicity, and recently South Korea has witnessed a surge in cases. We aimed to evaluate the clinical and pathological features of patients with EOCRC, and to determine the predictors of overall survival.
Methods: In this retrospective study, EOCRC was defined as CRC diagnosed in patients aged < 50 years, and late-onset CRC was defined as CRC diagnosed in those over 75 years of age. The clinical and pathological characteristics of patients with EOCRC were compared with late-onset CRC. We also used multivariable Cox proportional hazard models to find predictors of overall survival in patients with EOCRC.
Results: The proportion of early-onset CRC was 9.1% of 518 patients with CRC, and the clinical and pathological characteristics were similar between early-onset (n = 47) and late-onset CRC (n = 134). However, EOCRC had a preponderance for distal tumor location (70.2% vs. 50.7%, P = 0.02) and T1-2 stage disease (23.4% vs. 11.2%, P = 0.04), compared with those of late-onset CRC. Using multivariable Cox proportional hazard models, only vascular invasion (hazard ratio = 8.75, 95% confidence interval 1.139‒67.197) was found to be a risk factor for overall survival (P = 0.04) for patients with CRC.
Conclusion: EOCRC had preponderance for distal tumor location and early T-stage disease, compared with late-onset CRC. Considering the increasing incidence of EOCRC, more studies on clinical and pathological characteristics of EOCRC may be warranted. |
| first_indexed | 2024-04-24T14:21:40Z |
| format | Article |
| id | doaj.art-98e9d6c893114726b3fd38bc009ebdfc |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-04-24T14:21:40Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-98e9d6c893114726b3fd38bc009ebdfc2024-04-03T06:40:25ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492023-01-0129635836410.4103/sjg.sjg_35_23Clinical and pathological characteristics of early-onset colorectal cancer in South KoreaSu Bee ParkJin Young YoonMin Seob KwakJae Myung ChaBackground: Early-onset colorectal cancer (EOCRC) may differ by race and ethnicity, and recently South Korea has witnessed a surge in cases. We aimed to evaluate the clinical and pathological features of patients with EOCRC, and to determine the predictors of overall survival. Methods: In this retrospective study, EOCRC was defined as CRC diagnosed in patients aged < 50 years, and late-onset CRC was defined as CRC diagnosed in those over 75 years of age. The clinical and pathological characteristics of patients with EOCRC were compared with late-onset CRC. We also used multivariable Cox proportional hazard models to find predictors of overall survival in patients with EOCRC. Results: The proportion of early-onset CRC was 9.1% of 518 patients with CRC, and the clinical and pathological characteristics were similar between early-onset (n = 47) and late-onset CRC (n = 134). However, EOCRC had a preponderance for distal tumor location (70.2% vs. 50.7%, P = 0.02) and T1-2 stage disease (23.4% vs. 11.2%, P = 0.04), compared with those of late-onset CRC. Using multivariable Cox proportional hazard models, only vascular invasion (hazard ratio = 8.75, 95% confidence interval 1.139‒67.197) was found to be a risk factor for overall survival (P = 0.04) for patients with CRC. Conclusion: EOCRC had preponderance for distal tumor location and early T-stage disease, compared with late-onset CRC. Considering the increasing incidence of EOCRC, more studies on clinical and pathological characteristics of EOCRC may be warranted.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2023;volume=29;issue=6;spage=358;epage=364;aulast=Parkageearly-onset colorectal cancerpathologyrisk factorsurvival |
| spellingShingle | Su Bee Park Jin Young Yoon Min Seob Kwak Jae Myung Cha Clinical and pathological characteristics of early-onset colorectal cancer in South Korea The Saudi Journal of Gastroenterology age early-onset colorectal cancer pathology risk factor survival |
| title | Clinical and pathological characteristics of early-onset colorectal cancer in South Korea |
| title_full | Clinical and pathological characteristics of early-onset colorectal cancer in South Korea |
| title_fullStr | Clinical and pathological characteristics of early-onset colorectal cancer in South Korea |
| title_full_unstemmed | Clinical and pathological characteristics of early-onset colorectal cancer in South Korea |
| title_short | Clinical and pathological characteristics of early-onset colorectal cancer in South Korea |
| title_sort | clinical and pathological characteristics of early onset colorectal cancer in south korea |
| topic | age early-onset colorectal cancer pathology risk factor survival |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2023;volume=29;issue=6;spage=358;epage=364;aulast=Park |
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