<i>S. boulardii</i> Early Intervention Maintains Gut Microbiome Structure and Promotes Gut Mucosal Barrier Function in Early-Weaned Rats
Early weaning leads to the disorder of the gut microbiome and gut mucosal barrier injury. Early intervention of gut microbiome colonization contributes to the development of the gut microbiome and gut function. The aim of this study was to explore the effects of <i>Saccharomyces boulardii</...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/17/3485 |
| _version_ | 1797493863125876736 |
|---|---|
| author | Zhipeng Yang Yanting Wu Xiangchen Liu Mei Zhang Jian Peng Hongkui Wei |
| author_facet | Zhipeng Yang Yanting Wu Xiangchen Liu Mei Zhang Jian Peng Hongkui Wei |
| author_sort | Zhipeng Yang |
| collection | DOAJ |
| description | Early weaning leads to the disorder of the gut microbiome and gut mucosal barrier injury. Early intervention of gut microbiome colonization contributes to the development of the gut microbiome and gut function. The aim of this study was to explore the effects of <i>Saccharomyces boulardii</i> (<i>S. boulardii</i>) early intervention on the gut microbiome structure and gut mucosal barrier function of early-weaned rats. The results showed that <i>S. boulardii</i> early intervention improved growth performance along with a decrease in pathogenic bacteria, an increase in beneficial bacteria, a stable and complex microbiome, and a high level of microbial metabolism. Moreover, <i>S. boulardii</i> upregulated the mucosal barrier function including goblet cells and relative gene expression, tight junction, and sIgA level. Furthermore, <i>S. boulardii</i> suppressed the inflammatory response and promoted the anti-inflammatory response. Our study may provide a possible early intervention strategy for preventing an early weaning-induced disorder of the gut microbiome and loss of gut mucosal barrier function. |
| first_indexed | 2024-03-10T01:26:04Z |
| format | Article |
| id | doaj.art-98eac5d3ee64447e9daf5e200ea6ff26 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:26:04Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-98eac5d3ee64447e9daf5e200ea6ff262023-11-23T13:51:14ZengMDPI AGNutrients2072-66432022-08-011417348510.3390/nu14173485<i>S. boulardii</i> Early Intervention Maintains Gut Microbiome Structure and Promotes Gut Mucosal Barrier Function in Early-Weaned RatsZhipeng Yang0Yanting Wu1Xiangchen Liu2Mei Zhang3Jian Peng4Hongkui Wei5Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaEarly weaning leads to the disorder of the gut microbiome and gut mucosal barrier injury. Early intervention of gut microbiome colonization contributes to the development of the gut microbiome and gut function. The aim of this study was to explore the effects of <i>Saccharomyces boulardii</i> (<i>S. boulardii</i>) early intervention on the gut microbiome structure and gut mucosal barrier function of early-weaned rats. The results showed that <i>S. boulardii</i> early intervention improved growth performance along with a decrease in pathogenic bacteria, an increase in beneficial bacteria, a stable and complex microbiome, and a high level of microbial metabolism. Moreover, <i>S. boulardii</i> upregulated the mucosal barrier function including goblet cells and relative gene expression, tight junction, and sIgA level. Furthermore, <i>S. boulardii</i> suppressed the inflammatory response and promoted the anti-inflammatory response. Our study may provide a possible early intervention strategy for preventing an early weaning-induced disorder of the gut microbiome and loss of gut mucosal barrier function.https://www.mdpi.com/2072-6643/14/17/3485early-weaned rats<i>Saccharomyces boulardii</i>gut mucosal barriergut microbiome homeostasisinflammatory responsesmicrobial metabolism |
| spellingShingle | Zhipeng Yang Yanting Wu Xiangchen Liu Mei Zhang Jian Peng Hongkui Wei <i>S. boulardii</i> Early Intervention Maintains Gut Microbiome Structure and Promotes Gut Mucosal Barrier Function in Early-Weaned Rats Nutrients early-weaned rats <i>Saccharomyces boulardii</i> gut mucosal barrier gut microbiome homeostasis inflammatory responses microbial metabolism |
| title | <i>S. boulardii</i> Early Intervention Maintains Gut Microbiome Structure and Promotes Gut Mucosal Barrier Function in Early-Weaned Rats |
| title_full | <i>S. boulardii</i> Early Intervention Maintains Gut Microbiome Structure and Promotes Gut Mucosal Barrier Function in Early-Weaned Rats |
| title_fullStr | <i>S. boulardii</i> Early Intervention Maintains Gut Microbiome Structure and Promotes Gut Mucosal Barrier Function in Early-Weaned Rats |
| title_full_unstemmed | <i>S. boulardii</i> Early Intervention Maintains Gut Microbiome Structure and Promotes Gut Mucosal Barrier Function in Early-Weaned Rats |
| title_short | <i>S. boulardii</i> Early Intervention Maintains Gut Microbiome Structure and Promotes Gut Mucosal Barrier Function in Early-Weaned Rats |
| title_sort | i s boulardii i early intervention maintains gut microbiome structure and promotes gut mucosal barrier function in early weaned rats |
| topic | early-weaned rats <i>Saccharomyces boulardii</i> gut mucosal barrier gut microbiome homeostasis inflammatory responses microbial metabolism |
| url | https://www.mdpi.com/2072-6643/14/17/3485 |
| work_keys_str_mv | AT zhipengyang isboulardiiiearlyinterventionmaintainsgutmicrobiomestructureandpromotesgutmucosalbarrierfunctioninearlyweanedrats AT yantingwu isboulardiiiearlyinterventionmaintainsgutmicrobiomestructureandpromotesgutmucosalbarrierfunctioninearlyweanedrats AT xiangchenliu isboulardiiiearlyinterventionmaintainsgutmicrobiomestructureandpromotesgutmucosalbarrierfunctioninearlyweanedrats AT meizhang isboulardiiiearlyinterventionmaintainsgutmicrobiomestructureandpromotesgutmucosalbarrierfunctioninearlyweanedrats AT jianpeng isboulardiiiearlyinterventionmaintainsgutmicrobiomestructureandpromotesgutmucosalbarrierfunctioninearlyweanedrats AT hongkuiwei isboulardiiiearlyinterventionmaintainsgutmicrobiomestructureandpromotesgutmucosalbarrierfunctioninearlyweanedrats |