Application of Metagenomic Analyses in Dentistry as a Novel Strategy Enabling Complex Insight into Microbial Diversity of the Oral Cavity
The composition of the oral microbiome in healthy individuals is complex and dynamic, and depends on many factors, such as anatomi­cal location in the oral cavity, diet, oral hygiene habits or host immune responses. It is estimated at present that worldwide about 2 billion people suffer from...
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| Format: | Article |
| Language: | English |
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Sciendo
2017-03-01
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| Series: | Polish Journal of Microbiology |
| Subjects: | |
| Online Access: | https://www.exeley.com/exeley/journals/polish_journal_of_microbiology/66/1/pdf/10.5604_17331331.1234988.pdf |
| _version_ | 1818016612167450624 |
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| author | Aleksandra Burczyńska Łukasz Dziewit Przemysław Decewicz Izabela Strużycka Marta Wróblewska |
| author_facet | Aleksandra Burczyńska Łukasz Dziewit Przemysław Decewicz Izabela Strużycka Marta Wróblewska |
| author_sort | Aleksandra Burczyńska |
| collection | DOAJ |
| description | The composition of the oral microbiome in healthy individuals is complex and dynamic, and depends on many factors, such as anatomi­cal location in the oral cavity, diet, oral hygiene habits or host immune responses. It is estimated at present that worldwide about 2 billion people suffer from diseases of the oral cavity, mainly periodontal disease and dental caries. Importantly, the oral microflora involved in local infections may spread and cause systemic, even life-threatening infections. In search for etiological agents of infections in dentistry, traditional approaches are not sufficient, as about 50% of oral bacteria are not cultivable. Instead, metagenomic analyses are particularly useful for studies of the complex oral microbiome – both in healthy individuals, and in patients with oral and dental diseases. In this paper we review the current and future applications of metagenomic studies in evaluation of both the composition of the oral microbiome as well as its potential pathogenic role in infections in dentistry. |
| first_indexed | 2024-04-14T07:14:57Z |
| format | Article |
| id | doaj.art-98eb38d004404a188503e01064340109 |
| institution | Directory Open Access Journal |
| issn | 1733-1331 2544-4646 |
| language | English |
| last_indexed | 2024-04-14T07:14:57Z |
| publishDate | 2017-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Polish Journal of Microbiology |
| spelling | doaj.art-98eb38d004404a188503e010643401092022-12-22T02:06:19ZengSciendoPolish Journal of Microbiology1733-13312544-46462017-03-0166110.5604/17331331.1234988Application of Metagenomic Analyses in Dentistry as a Novel Strategy Enabling Complex Insight into Microbial Diversity of the Oral CavityAleksandra Burczyńska0Łukasz Dziewit1Przemysław Decewicz2Izabela Strużycka3Marta Wróblewska4Department of Dental Microbiology, Medical University of Warsaw, PolandDepartment of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, PolandResearch and Development for Life Sciences Ltd., PolandDepartment of Comprehensive Dental Care, Medical University of Warsaw, PolandDepartment of Microbiology, Central Clinical Hospital in Warsaw, PolandThe composition of the oral microbiome in healthy individuals is complex and dynamic, and depends on many factors, such as anatomi­cal location in the oral cavity, diet, oral hygiene habits or host immune responses. It is estimated at present that worldwide about 2 billion people suffer from diseases of the oral cavity, mainly periodontal disease and dental caries. Importantly, the oral microflora involved in local infections may spread and cause systemic, even life-threatening infections. In search for etiological agents of infections in dentistry, traditional approaches are not sufficient, as about 50% of oral bacteria are not cultivable. Instead, metagenomic analyses are particularly useful for studies of the complex oral microbiome – both in healthy individuals, and in patients with oral and dental diseases. In this paper we review the current and future applications of metagenomic studies in evaluation of both the composition of the oral microbiome as well as its potential pathogenic role in infections in dentistry.https://www.exeley.com/exeley/journals/polish_journal_of_microbiology/66/1/pdf/10.5604_17331331.1234988.pdfdental cariesendodonticsmetagenomicsperiapical abscessperiodontitis |
| spellingShingle | Aleksandra Burczyńska Łukasz Dziewit Przemysław Decewicz Izabela Strużycka Marta Wróblewska Application of Metagenomic Analyses in Dentistry as a Novel Strategy Enabling Complex Insight into Microbial Diversity of the Oral Cavity Polish Journal of Microbiology dental caries endodontics metagenomics periapical abscess periodontitis |
| title | Application of Metagenomic Analyses in Dentistry as a Novel Strategy Enabling Complex Insight into Microbial Diversity of the Oral Cavity |
| title_full | Application of Metagenomic Analyses in Dentistry as a Novel Strategy Enabling Complex Insight into Microbial Diversity of the Oral Cavity |
| title_fullStr | Application of Metagenomic Analyses in Dentistry as a Novel Strategy Enabling Complex Insight into Microbial Diversity of the Oral Cavity |
| title_full_unstemmed | Application of Metagenomic Analyses in Dentistry as a Novel Strategy Enabling Complex Insight into Microbial Diversity of the Oral Cavity |
| title_short | Application of Metagenomic Analyses in Dentistry as a Novel Strategy Enabling Complex Insight into Microbial Diversity of the Oral Cavity |
| title_sort | application of metagenomic analyses in dentistry as a novel strategy enabling complex insight into microbial diversity of the oral cavity |
| topic | dental caries endodontics metagenomics periapical abscess periodontitis |
| url | https://www.exeley.com/exeley/journals/polish_journal_of_microbiology/66/1/pdf/10.5604_17331331.1234988.pdf |
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