Effects of Red and Infrared Laser Therapy in Patients with Tinnitus: A Double-Blind, Clinical, Randomized Controlled Study Combining Light with Ultrasound, Drugs and Vacuum Therapy
Background: tinnitus is a symptom with no specific cause known to date, and there are no associated pharmacogenomics of hearing disorders and no FDA-approved drugs for tinnitus treatment. The effectiveness of drug treatments is not reproducible on idiopathic patients and inexistent in refractory pat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/4/581 |
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| author | Vitor Hugo Panhóca Antônio Eduardo de Aquino Junior Viviane Brocca de Souza Simone Aparecida Ferreira Lais Tatiane Ferreira Karina Jullienne de Oliveira Souza Patricia Eriko Tamae Marcelo Saito Nogueira Vanderlei Salvador Bagnato |
| author_facet | Vitor Hugo Panhóca Antônio Eduardo de Aquino Junior Viviane Brocca de Souza Simone Aparecida Ferreira Lais Tatiane Ferreira Karina Jullienne de Oliveira Souza Patricia Eriko Tamae Marcelo Saito Nogueira Vanderlei Salvador Bagnato |
| author_sort | Vitor Hugo Panhóca |
| collection | DOAJ |
| description | Background: tinnitus is a symptom with no specific cause known to date, and there are no associated pharmacogenomics of hearing disorders and no FDA-approved drugs for tinnitus treatment. The effectiveness of drug treatments is not reproducible on idiopathic patients and inexistent in refractory patients. Personalized treatments for these patients are a great clinical need. Our study investigated the outcome of potential alternative and complementary treatment modalities for idiopathic and refractory tinnitus patients. Methods: we were the first to evaluate the tinnitus handicap inventory (THI) score changes over the course of treatment up to 15 days after complete cessation of treatment for novel transmeatal low-level laser therapy (LLLT) modalities using light alone, as well as LLLT combined with vacuum therapy (VT), ultrasound (US), Ginkgo biloba (GB) and flunarizine dihydrochloride (FD), while also comparing all treatment outcomes with laser puncture (LP), FD alone and GB alone. Results: a positive treatment outcome (superior to a placebo effect) was achieved by using either LP or transmeatal LLLT, whereas short-term antagonistic effects of VT, US, GB and FD when combined with LLLT. For transmeatal LLLT, an improvement in the treatment outcome was observed by increasing the irradiation time from 6 min to 15 min (with 100-mW of applied laser power at 660 nm). Finally, a lasting therapeutic effect higher than the placebo was observed at 15 days after treatment upon combining LLLT with VT, GB or by using FD alone, by using the transmeatal LLLT alone or by using LP. Conclusions: LP and Transmeatal LLLT can be promising alternative treatments for idiopathic and refractory tinnitus patients. Future studies should investigate the long-term effects of LLLT in tinnitus patients, as well as the dosimetry and wavelength of transmeatal LLLT. |
| first_indexed | 2024-03-11T04:51:12Z |
| format | Article |
| id | doaj.art-98eea9c5a6d141f0a98f2fd24ffeaa54 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T04:51:12Z |
| publishDate | 2023-03-01 |
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| series | Journal of Personalized Medicine |
| spelling | doaj.art-98eea9c5a6d141f0a98f2fd24ffeaa542023-11-17T19:59:11ZengMDPI AGJournal of Personalized Medicine2075-44262023-03-0113458110.3390/jpm13040581Effects of Red and Infrared Laser Therapy in Patients with Tinnitus: A Double-Blind, Clinical, Randomized Controlled Study Combining Light with Ultrasound, Drugs and Vacuum TherapyVitor Hugo Panhóca0Antônio Eduardo de Aquino Junior1Viviane Brocca de Souza2Simone Aparecida Ferreira3Lais Tatiane Ferreira4Karina Jullienne de Oliveira Souza5Patricia Eriko Tamae6Marcelo Saito Nogueira7Vanderlei Salvador Bagnato8Biophotonics Laboratory, Institute of Physics of São Carlos, University of São Paulo, São Carlos 13563-120, SP, BrazilBiophotonics Laboratory, Institute of Physics of São Carlos, University of São Paulo, São Carlos 13563-120, SP, BrazilBiophotonics Laboratory, Institute of Physics of São Carlos, University of São Paulo, São Carlos 13563-120, SP, BrazilBiophotonics Laboratory, Institute of Physics of São Carlos, University of São Paulo, São Carlos 13563-120, SP, BrazilBiophotonics Laboratory, Institute of Physics of São Carlos, University of São Paulo, São Carlos 13563-120, SP, BrazilIntegrated Therapy Center, Londrina 86055-240, PR, BrazilCentral Paulista University Center—UNICEP, São Carlos 13563-470, SP, BrazilBiophotonics Laboratory, Institute of Physics of São Carlos, University of São Paulo, São Carlos 13563-120, SP, BrazilBiophotonics Laboratory, Institute of Physics of São Carlos, University of São Paulo, São Carlos 13563-120, SP, BrazilBackground: tinnitus is a symptom with no specific cause known to date, and there are no associated pharmacogenomics of hearing disorders and no FDA-approved drugs for tinnitus treatment. The effectiveness of drug treatments is not reproducible on idiopathic patients and inexistent in refractory patients. Personalized treatments for these patients are a great clinical need. Our study investigated the outcome of potential alternative and complementary treatment modalities for idiopathic and refractory tinnitus patients. Methods: we were the first to evaluate the tinnitus handicap inventory (THI) score changes over the course of treatment up to 15 days after complete cessation of treatment for novel transmeatal low-level laser therapy (LLLT) modalities using light alone, as well as LLLT combined with vacuum therapy (VT), ultrasound (US), Ginkgo biloba (GB) and flunarizine dihydrochloride (FD), while also comparing all treatment outcomes with laser puncture (LP), FD alone and GB alone. Results: a positive treatment outcome (superior to a placebo effect) was achieved by using either LP or transmeatal LLLT, whereas short-term antagonistic effects of VT, US, GB and FD when combined with LLLT. For transmeatal LLLT, an improvement in the treatment outcome was observed by increasing the irradiation time from 6 min to 15 min (with 100-mW of applied laser power at 660 nm). Finally, a lasting therapeutic effect higher than the placebo was observed at 15 days after treatment upon combining LLLT with VT, GB or by using FD alone, by using the transmeatal LLLT alone or by using LP. Conclusions: LP and Transmeatal LLLT can be promising alternative treatments for idiopathic and refractory tinnitus patients. Future studies should investigate the long-term effects of LLLT in tinnitus patients, as well as the dosimetry and wavelength of transmeatal LLLT.https://www.mdpi.com/2075-4426/13/4/581low-level laser therapyvacuum therapyultrasoundtinnitusphotobiomodulationphototherapy |
| spellingShingle | Vitor Hugo Panhóca Antônio Eduardo de Aquino Junior Viviane Brocca de Souza Simone Aparecida Ferreira Lais Tatiane Ferreira Karina Jullienne de Oliveira Souza Patricia Eriko Tamae Marcelo Saito Nogueira Vanderlei Salvador Bagnato Effects of Red and Infrared Laser Therapy in Patients with Tinnitus: A Double-Blind, Clinical, Randomized Controlled Study Combining Light with Ultrasound, Drugs and Vacuum Therapy Journal of Personalized Medicine low-level laser therapy vacuum therapy ultrasound tinnitus photobiomodulation phototherapy |
| title | Effects of Red and Infrared Laser Therapy in Patients with Tinnitus: A Double-Blind, Clinical, Randomized Controlled Study Combining Light with Ultrasound, Drugs and Vacuum Therapy |
| title_full | Effects of Red and Infrared Laser Therapy in Patients with Tinnitus: A Double-Blind, Clinical, Randomized Controlled Study Combining Light with Ultrasound, Drugs and Vacuum Therapy |
| title_fullStr | Effects of Red and Infrared Laser Therapy in Patients with Tinnitus: A Double-Blind, Clinical, Randomized Controlled Study Combining Light with Ultrasound, Drugs and Vacuum Therapy |
| title_full_unstemmed | Effects of Red and Infrared Laser Therapy in Patients with Tinnitus: A Double-Blind, Clinical, Randomized Controlled Study Combining Light with Ultrasound, Drugs and Vacuum Therapy |
| title_short | Effects of Red and Infrared Laser Therapy in Patients with Tinnitus: A Double-Blind, Clinical, Randomized Controlled Study Combining Light with Ultrasound, Drugs and Vacuum Therapy |
| title_sort | effects of red and infrared laser therapy in patients with tinnitus a double blind clinical randomized controlled study combining light with ultrasound drugs and vacuum therapy |
| topic | low-level laser therapy vacuum therapy ultrasound tinnitus photobiomodulation phototherapy |
| url | https://www.mdpi.com/2075-4426/13/4/581 |
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