Excitability changes in the sciatic nerve and triceps surae muscle after spinal cord injury in mice
<p>Abstract</p> <p>Background</p> <p>From the onset to the chronic phase of spinal cord injury (SCI), peripheral axons and muscles are subjected to abnormal states of activity. This starts with very intense spasms during the first instant of SCI, through a no activity f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2010-04-01
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| Series: | Journal of Brachial Plexus and Peripheral Nerve Injury |
| Online Access: | http://www.jbppni.com/content/5/1/8 |
| _version_ | 1811244280674516992 |
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| author | Freedland Robert Ahmed Zaghloul Wieraszko Andrzej |
| author_facet | Freedland Robert Ahmed Zaghloul Wieraszko Andrzej |
| author_sort | Freedland Robert |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>From the onset to the chronic phase of spinal cord injury (SCI), peripheral axons and muscles are subjected to abnormal states of activity. This starts with very intense spasms during the first instant of SCI, through a no activity flaccidity phase, to a chronic hyperactivity phase. It remains unclear how the nature of this sequence may affect the peripheral axons and muscles.</p> <p>Methods</p> <p>We set out to investigate the changes in excitability of the sciatic nerve and to characterize the properties of muscle contractility after contusive injury of the mouse thoracic spinal cord.</p> <p>Results</p> <p>The following changes were observed in animals after SCI: 1) The sciatic nerve compound action potential was of higher amplitudes and lower threshold, with the longer strength-duration time constant and faster conduction velocity; 2) The latency of the onset of muscle contraction of the triceps surae muscle was significantly shorter in animals with SCI; 3) The muscle twitches expressed slower rising and falling slopes, which were accompanied by prolonged contraction duration in SCI animals compared to controls.</p> <p>Conclusion</p> <p>These findings suggest that in peripheral nerves SCI promotes hyperexcitability, which might contribute to mechanisms of spastic syndrome.</p> |
| first_indexed | 2024-04-12T14:22:04Z |
| format | Article |
| id | doaj.art-98f0f3511e0d4a128094adaacfa08d11 |
| institution | Directory Open Access Journal |
| issn | 1749-7221 |
| language | English |
| last_indexed | 2024-04-12T14:22:04Z |
| publishDate | 2010-04-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Journal of Brachial Plexus and Peripheral Nerve Injury |
| spelling | doaj.art-98f0f3511e0d4a128094adaacfa08d112022-12-22T03:29:32ZengGeorg Thieme Verlag KGJournal of Brachial Plexus and Peripheral Nerve Injury1749-72212010-04-0151810.1186/1749-7221-5-8Excitability changes in the sciatic nerve and triceps surae muscle after spinal cord injury in miceFreedland RobertAhmed ZaghloulWieraszko Andrzej<p>Abstract</p> <p>Background</p> <p>From the onset to the chronic phase of spinal cord injury (SCI), peripheral axons and muscles are subjected to abnormal states of activity. This starts with very intense spasms during the first instant of SCI, through a no activity flaccidity phase, to a chronic hyperactivity phase. It remains unclear how the nature of this sequence may affect the peripheral axons and muscles.</p> <p>Methods</p> <p>We set out to investigate the changes in excitability of the sciatic nerve and to characterize the properties of muscle contractility after contusive injury of the mouse thoracic spinal cord.</p> <p>Results</p> <p>The following changes were observed in animals after SCI: 1) The sciatic nerve compound action potential was of higher amplitudes and lower threshold, with the longer strength-duration time constant and faster conduction velocity; 2) The latency of the onset of muscle contraction of the triceps surae muscle was significantly shorter in animals with SCI; 3) The muscle twitches expressed slower rising and falling slopes, which were accompanied by prolonged contraction duration in SCI animals compared to controls.</p> <p>Conclusion</p> <p>These findings suggest that in peripheral nerves SCI promotes hyperexcitability, which might contribute to mechanisms of spastic syndrome.</p>http://www.jbppni.com/content/5/1/8 |
| spellingShingle | Freedland Robert Ahmed Zaghloul Wieraszko Andrzej Excitability changes in the sciatic nerve and triceps surae muscle after spinal cord injury in mice Journal of Brachial Plexus and Peripheral Nerve Injury |
| title | Excitability changes in the sciatic nerve and triceps surae muscle after spinal cord injury in mice |
| title_full | Excitability changes in the sciatic nerve and triceps surae muscle after spinal cord injury in mice |
| title_fullStr | Excitability changes in the sciatic nerve and triceps surae muscle after spinal cord injury in mice |
| title_full_unstemmed | Excitability changes in the sciatic nerve and triceps surae muscle after spinal cord injury in mice |
| title_short | Excitability changes in the sciatic nerve and triceps surae muscle after spinal cord injury in mice |
| title_sort | excitability changes in the sciatic nerve and triceps surae muscle after spinal cord injury in mice |
| url | http://www.jbppni.com/content/5/1/8 |
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