Contacting the gut: Mitochondria-associated Endoplasmic Reticulum Membranes in the Enteric Nervous System
Changes in the connections between the endoplasmic reticulum (ER) and mitochondria, as well as alterations in mitochondria-associated ER membrane (MAM) signalling, have been documented in various neurodegenerative diseases affecting the brain. Despite the growing recognition of the significance of t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-04-01
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| Series: | Contact |
| Online Access: | https://doi.org/10.1177/25152564241244941 |
| _version_ | 1797220684113379328 |
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| author | Jenny Greig Giada Delfino Pascal Derkinderen Sébastien Paillusson |
| author_facet | Jenny Greig Giada Delfino Pascal Derkinderen Sébastien Paillusson |
| author_sort | Jenny Greig |
| collection | DOAJ |
| description | Changes in the connections between the endoplasmic reticulum (ER) and mitochondria, as well as alterations in mitochondria-associated ER membrane (MAM) signalling, have been documented in various neurodegenerative diseases affecting the brain. Despite the growing recognition of the significance of the gut-brain axis in neurodegenerative conditions, there has been no prior investigation into the biology of MAM within the enteric nervous system (ENS). Our recent research reveals, for the first time, the existence of connections between the ER and mitochondria within enteric neurons. Additionally, we observed alterations in the dynamics of these connections in the enteric neurons from a mouse model exhibiting age-related neurodegeneration. These findings provide the first detailed characterization of MAM in the ENS under physiological conditions and in a mouse model of age-associated neurodegeneration and shed new light on the potential role of enteric MAM in the context of neurodegenerative disorders. |
| first_indexed | 2024-04-24T12:53:27Z |
| format | Article |
| id | doaj.art-98f141a390d646d6951fdf51e5bd2d54 |
| institution | Directory Open Access Journal |
| issn | 2515-2564 |
| language | English |
| last_indexed | 2024-04-24T12:53:27Z |
| publishDate | 2024-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Contact |
| spelling | doaj.art-98f141a390d646d6951fdf51e5bd2d542024-04-05T17:03:21ZengSAGE PublishingContact2515-25642024-04-01710.1177/25152564241244941Contacting the gut: Mitochondria-associated Endoplasmic Reticulum Membranes in the Enteric Nervous SystemJenny Greig0Giada Delfino1Pascal Derkinderen2Sébastien Paillusson3 INSERM, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France Nantes Université, INSERM, CHU Nantes, The Enteric Nervous System in Gut and Brain Disorders, Nantes, France Nantes Université, INSERM, CHU Nantes, The Enteric Nervous System in Gut and Brain Disorders, Nantes, France Nantes Université, INSERM, CHU Nantes, The Enteric Nervous System in Gut and Brain Disorders, Nantes, FranceChanges in the connections between the endoplasmic reticulum (ER) and mitochondria, as well as alterations in mitochondria-associated ER membrane (MAM) signalling, have been documented in various neurodegenerative diseases affecting the brain. Despite the growing recognition of the significance of the gut-brain axis in neurodegenerative conditions, there has been no prior investigation into the biology of MAM within the enteric nervous system (ENS). Our recent research reveals, for the first time, the existence of connections between the ER and mitochondria within enteric neurons. Additionally, we observed alterations in the dynamics of these connections in the enteric neurons from a mouse model exhibiting age-related neurodegeneration. These findings provide the first detailed characterization of MAM in the ENS under physiological conditions and in a mouse model of age-associated neurodegeneration and shed new light on the potential role of enteric MAM in the context of neurodegenerative disorders.https://doi.org/10.1177/25152564241244941 |
| spellingShingle | Jenny Greig Giada Delfino Pascal Derkinderen Sébastien Paillusson Contacting the gut: Mitochondria-associated Endoplasmic Reticulum Membranes in the Enteric Nervous System Contact |
| title | Contacting the gut: Mitochondria-associated Endoplasmic Reticulum Membranes in the Enteric Nervous System |
| title_full | Contacting the gut: Mitochondria-associated Endoplasmic Reticulum Membranes in the Enteric Nervous System |
| title_fullStr | Contacting the gut: Mitochondria-associated Endoplasmic Reticulum Membranes in the Enteric Nervous System |
| title_full_unstemmed | Contacting the gut: Mitochondria-associated Endoplasmic Reticulum Membranes in the Enteric Nervous System |
| title_short | Contacting the gut: Mitochondria-associated Endoplasmic Reticulum Membranes in the Enteric Nervous System |
| title_sort | contacting the gut mitochondria associated endoplasmic reticulum membranes in the enteric nervous system |
| url | https://doi.org/10.1177/25152564241244941 |
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