External counterpulsation stimulation combined with acupuncture for vascular endothelial function in patients with hypertension: A randomized pilot trial
Objective Endothelial function may improve with enhanced external counterpulsation (EECP) or acupuncture. This study aimed to evaluate the feasibility of acupoint stimulation combined with EECP (acupoint-EECP) for endothelial cell function in patients with essential hypertension. Methods Thirty esse...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2023.2181355 |
| _version_ | 1797681036555976704 |
|---|---|
| author | Meilan Lin Xiaonv Wang Bingbing Ye Jun Zhang Shuman Lin Yiye Xu Jianguan Zhou Sipei Liu Shiwei Zhou Xiafei Guan Yan Jin Lei Wang |
| author_facet | Meilan Lin Xiaonv Wang Bingbing Ye Jun Zhang Shuman Lin Yiye Xu Jianguan Zhou Sipei Liu Shiwei Zhou Xiafei Guan Yan Jin Lei Wang |
| author_sort | Meilan Lin |
| collection | DOAJ |
| description | Objective Endothelial function may improve with enhanced external counterpulsation (EECP) or acupuncture. This study aimed to evaluate the feasibility of acupoint stimulation combined with EECP (acupoint-EECP) for endothelial cell function in patients with essential hypertension. Methods Thirty essential hypertensive patients were, randomly divided into two groups, with 15 patients in the acupoint-EECP group, and 15 patients in the control group, of which 3 cases were lost by week 6. Both groups were treated with continued medicine. The participants in the acupoint-EECP group received acupoint stimulation combined with EECP therapy, 45 min for each time, 5 times weekly for 6 weeks for a total of 22.5 hours. The selected acupoints are Zusanli (ST36), Fenglong (ST40) and Sanyinjiao (SP6). The curative effects of the two groups were compared. Results The acupoint-EECP group (n=15) showed significant improvement in endothelial function [nitric oxide (NO) ，endothelin-1 (ET-1) and carotid-femoral pulse wave velocity (cf-PWV), respectively] values compared to the control group (n=12). Multiple imputation (n = 20 imputations) was performed to account for potential bias due to missing data. In stratified analyses, SBP and DBP values decreased when the baseline SBP was ≥120 mmHg and DBP was ≥80 mmHg. Conclusions These findings suggest the feasibility of acupoint-EECP in improving endothelial function and treating hypertension. (The Chinese clinical trial registration number is ChiCTR2100053795.) |
| first_indexed | 2024-03-11T23:39:03Z |
| format | Article |
| id | doaj.art-98f15e2d09114b63ae170f34711fd938 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:39:03Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-98f15e2d09114b63ae170f34711fd9382023-09-19T16:04:08ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062023-12-0145110.1080/10641963.2023.21813552181355External counterpulsation stimulation combined with acupuncture for vascular endothelial function in patients with hypertension: A randomized pilot trialMeilan Lin0Xiaonv Wang1Bingbing Ye2Jun Zhang3Shuman Lin4Yiye Xu5Jianguan Zhou6Sipei Liu7Shiwei Zhou8Xiafei Guan9Yan Jin10Lei Wang11Clinical College of Nanjing University of Chinese MedicineRuian Hospital of Traditional Chinese MedicineRuian Hospital of Traditional Chinese MedicineRuian Hospital of Traditional Chinese MedicineRuian Hospital of Traditional Chinese MedicineRuian Hospital of Traditional Chinese MedicineRuian Hospital of Traditional Chinese MedicineClinical College of Nanjing University of Chinese MedicineRuian Hospital of Traditional Chinese MedicineRuian Hospital of Traditional Chinese MedicineClinical College of Nanjing University of Chinese MedicineClinical College of Nanjing University of Chinese MedicineObjective Endothelial function may improve with enhanced external counterpulsation (EECP) or acupuncture. This study aimed to evaluate the feasibility of acupoint stimulation combined with EECP (acupoint-EECP) for endothelial cell function in patients with essential hypertension. Methods Thirty essential hypertensive patients were, randomly divided into two groups, with 15 patients in the acupoint-EECP group, and 15 patients in the control group, of which 3 cases were lost by week 6. Both groups were treated with continued medicine. The participants in the acupoint-EECP group received acupoint stimulation combined with EECP therapy, 45 min for each time, 5 times weekly for 6 weeks for a total of 22.5 hours. The selected acupoints are Zusanli (ST36), Fenglong (ST40) and Sanyinjiao (SP6). The curative effects of the two groups were compared. Results The acupoint-EECP group (n=15) showed significant improvement in endothelial function [nitric oxide (NO) ，endothelin-1 (ET-1) and carotid-femoral pulse wave velocity (cf-PWV), respectively] values compared to the control group (n=12). Multiple imputation (n = 20 imputations) was performed to account for potential bias due to missing data. In stratified analyses, SBP and DBP values decreased when the baseline SBP was ≥120 mmHg and DBP was ≥80 mmHg. Conclusions These findings suggest the feasibility of acupoint-EECP in improving endothelial function and treating hypertension. (The Chinese clinical trial registration number is ChiCTR2100053795.)http://dx.doi.org/10.1080/10641963.2023.2181355blood pressureendothelinexternal counterpulsationacupressurenonpharmaceutical therapy |
| spellingShingle | Meilan Lin Xiaonv Wang Bingbing Ye Jun Zhang Shuman Lin Yiye Xu Jianguan Zhou Sipei Liu Shiwei Zhou Xiafei Guan Yan Jin Lei Wang External counterpulsation stimulation combined with acupuncture for vascular endothelial function in patients with hypertension: A randomized pilot trial Clinical and Experimental Hypertension blood pressure endothelin external counterpulsation acupressure nonpharmaceutical therapy |
| title | External counterpulsation stimulation combined with acupuncture for vascular endothelial function in patients with hypertension: A randomized pilot trial |
| title_full | External counterpulsation stimulation combined with acupuncture for vascular endothelial function in patients with hypertension: A randomized pilot trial |
| title_fullStr | External counterpulsation stimulation combined with acupuncture for vascular endothelial function in patients with hypertension: A randomized pilot trial |
| title_full_unstemmed | External counterpulsation stimulation combined with acupuncture for vascular endothelial function in patients with hypertension: A randomized pilot trial |
| title_short | External counterpulsation stimulation combined with acupuncture for vascular endothelial function in patients with hypertension: A randomized pilot trial |
| title_sort | external counterpulsation stimulation combined with acupuncture for vascular endothelial function in patients with hypertension a randomized pilot trial |
| topic | blood pressure endothelin external counterpulsation acupressure nonpharmaceutical therapy |
| url | http://dx.doi.org/10.1080/10641963.2023.2181355 |
| work_keys_str_mv | AT meilanlin externalcounterpulsationstimulationcombinedwithacupunctureforvascularendothelialfunctioninpatientswithhypertensionarandomizedpilottrial AT xiaonvwang externalcounterpulsationstimulationcombinedwithacupunctureforvascularendothelialfunctioninpatientswithhypertensionarandomizedpilottrial AT bingbingye externalcounterpulsationstimulationcombinedwithacupunctureforvascularendothelialfunctioninpatientswithhypertensionarandomizedpilottrial AT junzhang externalcounterpulsationstimulationcombinedwithacupunctureforvascularendothelialfunctioninpatientswithhypertensionarandomizedpilottrial AT shumanlin externalcounterpulsationstimulationcombinedwithacupunctureforvascularendothelialfunctioninpatientswithhypertensionarandomizedpilottrial AT yiyexu externalcounterpulsationstimulationcombinedwithacupunctureforvascularendothelialfunctioninpatientswithhypertensionarandomizedpilottrial AT jianguanzhou externalcounterpulsationstimulationcombinedwithacupunctureforvascularendothelialfunctioninpatientswithhypertensionarandomizedpilottrial AT sipeiliu externalcounterpulsationstimulationcombinedwithacupunctureforvascularendothelialfunctioninpatientswithhypertensionarandomizedpilottrial AT shiweizhou externalcounterpulsationstimulationcombinedwithacupunctureforvascularendothelialfunctioninpatientswithhypertensionarandomizedpilottrial AT xiafeiguan externalcounterpulsationstimulationcombinedwithacupunctureforvascularendothelialfunctioninpatientswithhypertensionarandomizedpilottrial AT yanjin externalcounterpulsationstimulationcombinedwithacupunctureforvascularendothelialfunctioninpatientswithhypertensionarandomizedpilottrial AT leiwang externalcounterpulsationstimulationcombinedwithacupunctureforvascularendothelialfunctioninpatientswithhypertensionarandomizedpilottrial |