Depression Mediates the Association Between Childhood Emotional Abuse and the Onset of Type 2 Diabetes: Findings From German Multi-Cohort Prospective Studies
BackgroundThe dysregulation of glucose homeostasis via mental health stress is increasingly acknowledged, whereby depression independently increases the risk of the onset of type 2 diabetes by up to 60%. Contributing mental health factors starting in early life have further been considered, indicati...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.825678/full |
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| author | Seryan Atasoy Seryan Atasoy Seryan Atasoy Hamimatunnisa Johar Hamimatunnisa Johar Toni Fleischer Manfred Beutel Harald Binder Elmar Braehler Georg Schomerus Daniela Zöller Johannes Kruse Karl-Heinz Ladwig Karl-Heinz Ladwig |
| author_facet | Seryan Atasoy Seryan Atasoy Seryan Atasoy Hamimatunnisa Johar Hamimatunnisa Johar Toni Fleischer Manfred Beutel Harald Binder Elmar Braehler Georg Schomerus Daniela Zöller Johannes Kruse Karl-Heinz Ladwig Karl-Heinz Ladwig |
| author_sort | Seryan Atasoy |
| collection | DOAJ |
| description | BackgroundThe dysregulation of glucose homeostasis via mental health stress is increasingly acknowledged, whereby depression independently increases the risk of the onset of type 2 diabetes by up to 60%. Contributing mental health factors starting in early life have further been considered, indicating that exposure to childhood emotional abuse is associated with both depression and an increased onset of type 2 diabetes in adulthood. However, the potential role of depression within the emotional abuse and type 2 diabetes link remains unknown.MethodsData were derived from community-dwelling participants in southern and northeastern Germany who participated in the longitudinal KORA-F4 and SHIP-3 studies. Multivariable logistic regression analyses adjusted for lifestyle, somatic, and psychological risk factors were used to investigate the association between childhood emotional abuse, assessed retrospectively by the Childhood Trauma Screener, and newly diagnosed type 2 diabetes cases, which were confirmed using a standard oral glucose tolerance test. The mediating role of depressive symptoms between childhood emotional abuse and type 2 diabetes was assessed by the Patient Health Questionnaire-9 and calculated by using the Sobel test for mediation.ResultsA total of 2,973 (53.2% women, 46.8% men) participants with a mean age of 49.7 were included in the analyses, of whom 5.9% (7.1% women, 4.5% men) reported emotional abuse in childhood. Participants exposed to childhood emotional abuse had a 1.70 (1.12–2.56; p = 0.02) times higher odds of depression in the fully adjusted model than unexposed participants. During the 6.5-year follow-up period, 104 (3.5%) participants developed type 2 diabetes. Participants who were exposed to childhood emotional abuse had a 2.56 (1.31–4.98, p = 0.005) times higher odds of developing type 2 diabetes than unexposed participants. This association was significantly mediated by the increased odds of depression in participants with childhood emotional abuse (Sobel Test, 1.84, p = 0.06; Goodman Test, 1.91, p = 0.05).ConclusionThe current results indicate that the increased likelihood of type 2 diabetes onset in participants who were exposed to childhood emotional abuse is significantly attributed to increased depression in adulthood. |
| first_indexed | 2024-12-21T05:04:04Z |
| format | Article |
| id | doaj.art-98f2dd457e5140c8af3f8b70b6ce9bc3 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-21T05:04:04Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-98f2dd457e5140c8af3f8b70b6ce9bc32022-12-21T19:15:10ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-04-011310.3389/fpsyt.2022.825678825678Depression Mediates the Association Between Childhood Emotional Abuse and the Onset of Type 2 Diabetes: Findings From German Multi-Cohort Prospective StudiesSeryan Atasoy0Seryan Atasoy1Seryan Atasoy2Hamimatunnisa Johar3Hamimatunnisa Johar4Toni Fleischer5Manfred Beutel6Harald Binder7Elmar Braehler8Georg Schomerus9Daniela Zöller10Johannes Kruse11Karl-Heinz Ladwig12Karl-Heinz Ladwig13Department of Psychosomatic Medicine and Psychotherapy, University of Giessen and Marburg, Giessen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, Klinikum Rechts der Isar, Technical University of Munich, Munich, GermanyInstitute of Epidemiology, Helmholtz Zentrum München, Munich, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University of Giessen and Marburg, Giessen, GermanyInstitute of Epidemiology, Helmholtz Zentrum München, Munich, GermanyDepartment of Psychiatry, Medical Faculty, Leipzig University, Leipzig, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, GermanyInstitute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg im Breisgau, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, GermanyDepartment of Psychiatry, Medical Faculty, Leipzig University, Leipzig, GermanyInstitute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg im Breisgau, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University of Giessen and Marburg, Giessen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, Klinikum Rechts der Isar, Technical University of Munich, Munich, GermanyGerman Center for Diabetes Research (DZD), Munich, GermanyBackgroundThe dysregulation of glucose homeostasis via mental health stress is increasingly acknowledged, whereby depression independently increases the risk of the onset of type 2 diabetes by up to 60%. Contributing mental health factors starting in early life have further been considered, indicating that exposure to childhood emotional abuse is associated with both depression and an increased onset of type 2 diabetes in adulthood. However, the potential role of depression within the emotional abuse and type 2 diabetes link remains unknown.MethodsData were derived from community-dwelling participants in southern and northeastern Germany who participated in the longitudinal KORA-F4 and SHIP-3 studies. Multivariable logistic regression analyses adjusted for lifestyle, somatic, and psychological risk factors were used to investigate the association between childhood emotional abuse, assessed retrospectively by the Childhood Trauma Screener, and newly diagnosed type 2 diabetes cases, which were confirmed using a standard oral glucose tolerance test. The mediating role of depressive symptoms between childhood emotional abuse and type 2 diabetes was assessed by the Patient Health Questionnaire-9 and calculated by using the Sobel test for mediation.ResultsA total of 2,973 (53.2% women, 46.8% men) participants with a mean age of 49.7 were included in the analyses, of whom 5.9% (7.1% women, 4.5% men) reported emotional abuse in childhood. Participants exposed to childhood emotional abuse had a 1.70 (1.12–2.56; p = 0.02) times higher odds of depression in the fully adjusted model than unexposed participants. During the 6.5-year follow-up period, 104 (3.5%) participants developed type 2 diabetes. Participants who were exposed to childhood emotional abuse had a 2.56 (1.31–4.98, p = 0.005) times higher odds of developing type 2 diabetes than unexposed participants. This association was significantly mediated by the increased odds of depression in participants with childhood emotional abuse (Sobel Test, 1.84, p = 0.06; Goodman Test, 1.91, p = 0.05).ConclusionThe current results indicate that the increased likelihood of type 2 diabetes onset in participants who were exposed to childhood emotional abuse is significantly attributed to increased depression in adulthood.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.825678/fulldepressionchildhood emotional abusetype 2 diabetesepidemiologylongitudinal |
| spellingShingle | Seryan Atasoy Seryan Atasoy Seryan Atasoy Hamimatunnisa Johar Hamimatunnisa Johar Toni Fleischer Manfred Beutel Harald Binder Elmar Braehler Georg Schomerus Daniela Zöller Johannes Kruse Karl-Heinz Ladwig Karl-Heinz Ladwig Depression Mediates the Association Between Childhood Emotional Abuse and the Onset of Type 2 Diabetes: Findings From German Multi-Cohort Prospective Studies Frontiers in Psychiatry depression childhood emotional abuse type 2 diabetes epidemiology longitudinal |
| title | Depression Mediates the Association Between Childhood Emotional Abuse and the Onset of Type 2 Diabetes: Findings From German Multi-Cohort Prospective Studies |
| title_full | Depression Mediates the Association Between Childhood Emotional Abuse and the Onset of Type 2 Diabetes: Findings From German Multi-Cohort Prospective Studies |
| title_fullStr | Depression Mediates the Association Between Childhood Emotional Abuse and the Onset of Type 2 Diabetes: Findings From German Multi-Cohort Prospective Studies |
| title_full_unstemmed | Depression Mediates the Association Between Childhood Emotional Abuse and the Onset of Type 2 Diabetes: Findings From German Multi-Cohort Prospective Studies |
| title_short | Depression Mediates the Association Between Childhood Emotional Abuse and the Onset of Type 2 Diabetes: Findings From German Multi-Cohort Prospective Studies |
| title_sort | depression mediates the association between childhood emotional abuse and the onset of type 2 diabetes findings from german multi cohort prospective studies |
| topic | depression childhood emotional abuse type 2 diabetes epidemiology longitudinal |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.825678/full |
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