The metabolic plasticity of B cells
The humoral response requires rapid growth, biosynthetic capacity, proliferation and differentiation of B cells. These processes involve profound B-cell phenotypic transitions that are coupled to drastic changes in metabolism so as to meet the extremely different energetic requirements as B cells sw...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.991188/full |
| _version_ | 1811209158964281344 |
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| author | Yurena Vivas-García Alejo Efeyan |
| author_facet | Yurena Vivas-García Alejo Efeyan |
| author_sort | Yurena Vivas-García |
| collection | DOAJ |
| description | The humoral response requires rapid growth, biosynthetic capacity, proliferation and differentiation of B cells. These processes involve profound B-cell phenotypic transitions that are coupled to drastic changes in metabolism so as to meet the extremely different energetic requirements as B cells switch from resting to an activated, highly proliferative state and to plasma or memory cell fates. Thus, B cells execute a multi-step, energetically dynamic process of profound metabolic rewiring from low ATP production to transient and large increments of energy expenditure that depend on high uptake and consumption of glucose and fatty acids. Such metabolic plasticity is under tight transcriptional and post-transcriptional regulation. Alterations in B-cell metabolism driven by genetic mutations or by extrinsic insults impair B-cell functions and differentiation and may underlie the anomalous behavior of pathological B cells. Herein, we review molecular switches that control B-cell metabolism and fuel utilization, as well as the emerging awareness of the impact of dynamic metabolic adaptations of B cells throughout the different phases of the humoral response. |
| first_indexed | 2024-04-12T04:34:49Z |
| format | Article |
| id | doaj.art-98f47212bd9b4130ba2efa0fbbe14ab1 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-12T04:34:49Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-98f47212bd9b4130ba2efa0fbbe14ab12022-12-22T03:47:50ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-09-01910.3389/fmolb.2022.991188991188The metabolic plasticity of B cellsYurena Vivas-GarcíaAlejo EfeyanThe humoral response requires rapid growth, biosynthetic capacity, proliferation and differentiation of B cells. These processes involve profound B-cell phenotypic transitions that are coupled to drastic changes in metabolism so as to meet the extremely different energetic requirements as B cells switch from resting to an activated, highly proliferative state and to plasma or memory cell fates. Thus, B cells execute a multi-step, energetically dynamic process of profound metabolic rewiring from low ATP production to transient and large increments of energy expenditure that depend on high uptake and consumption of glucose and fatty acids. Such metabolic plasticity is under tight transcriptional and post-transcriptional regulation. Alterations in B-cell metabolism driven by genetic mutations or by extrinsic insults impair B-cell functions and differentiation and may underlie the anomalous behavior of pathological B cells. Herein, we review molecular switches that control B-cell metabolism and fuel utilization, as well as the emerging awareness of the impact of dynamic metabolic adaptations of B cells throughout the different phases of the humoral response.https://www.frontiersin.org/articles/10.3389/fmolb.2022.991188/fullmetabolic plasticityB-cell activationhumoral responseglycolysisOxphosanabolism |
| spellingShingle | Yurena Vivas-García Alejo Efeyan The metabolic plasticity of B cells Frontiers in Molecular Biosciences metabolic plasticity B-cell activation humoral response glycolysis Oxphos anabolism |
| title | The metabolic plasticity of B cells |
| title_full | The metabolic plasticity of B cells |
| title_fullStr | The metabolic plasticity of B cells |
| title_full_unstemmed | The metabolic plasticity of B cells |
| title_short | The metabolic plasticity of B cells |
| title_sort | metabolic plasticity of b cells |
| topic | metabolic plasticity B-cell activation humoral response glycolysis Oxphos anabolism |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.991188/full |
| work_keys_str_mv | AT yurenavivasgarcia themetabolicplasticityofbcells AT alejoefeyan themetabolicplasticityofbcells AT yurenavivasgarcia metabolicplasticityofbcells AT alejoefeyan metabolicplasticityofbcells |