Functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimation
<p>Abstract</p> <p>Background</p> <p>The identification of genes or quantitative trait loci that are expressed in response to different environmental factors such as temperature and light, through functional mapping, critically relies on precise modeling of the covarian...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-01-01
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| Series: | BMC Plant Biology |
| Online Access: | http://www.biomedcentral.com/1471-2229/11/23 |
| _version_ | 1818491372031705088 |
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| author | Li Jiahan Das Kiranmoy Li Yao Yap John S Wu Rongling |
| author_facet | Li Jiahan Das Kiranmoy Li Yao Yap John S Wu Rongling |
| author_sort | Li Jiahan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The identification of genes or quantitative trait loci that are expressed in response to different environmental factors such as temperature and light, through functional mapping, critically relies on precise modeling of the covariance structure. Previous work used separable parametric covariance structures, such as a Kronecker product of autoregressive one [AR(1)] matrices, that do not account for interaction effects of different environmental factors.</p> <p>Results</p> <p>We implement a more robust nonparametric covariance estimator to model these interactions within the framework of functional mapping of reaction norms to two signals. Our results from Monte Carlo simulations show that this estimator can be useful in modeling interactions that exist between two environmental signals. The interactions are simulated using nonseparable covariance models with spatio-temporal structural forms that mimic interaction effects.</p> <p>Conclusions</p> <p>The nonparametric covariance estimator has an advantage over separable parametric covariance estimators in the detection of QTL location, thus extending the breadth of use of functional mapping in practical settings.</p> |
| first_indexed | 2024-12-10T17:29:57Z |
| format | Article |
| id | doaj.art-98f53e07db614630a07fb4762842f147 |
| institution | Directory Open Access Journal |
| issn | 1471-2229 |
| language | English |
| last_indexed | 2024-12-10T17:29:57Z |
| publishDate | 2011-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Plant Biology |
| spelling | doaj.art-98f53e07db614630a07fb4762842f1472022-12-22T01:39:43ZengBMCBMC Plant Biology1471-22292011-01-011112310.1186/1471-2229-11-23Functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimationLi JiahanDas KiranmoyLi YaoYap John SWu Rongling<p>Abstract</p> <p>Background</p> <p>The identification of genes or quantitative trait loci that are expressed in response to different environmental factors such as temperature and light, through functional mapping, critically relies on precise modeling of the covariance structure. Previous work used separable parametric covariance structures, such as a Kronecker product of autoregressive one [AR(1)] matrices, that do not account for interaction effects of different environmental factors.</p> <p>Results</p> <p>We implement a more robust nonparametric covariance estimator to model these interactions within the framework of functional mapping of reaction norms to two signals. Our results from Monte Carlo simulations show that this estimator can be useful in modeling interactions that exist between two environmental signals. The interactions are simulated using nonseparable covariance models with spatio-temporal structural forms that mimic interaction effects.</p> <p>Conclusions</p> <p>The nonparametric covariance estimator has an advantage over separable parametric covariance estimators in the detection of QTL location, thus extending the breadth of use of functional mapping in practical settings.</p>http://www.biomedcentral.com/1471-2229/11/23 |
| spellingShingle | Li Jiahan Das Kiranmoy Li Yao Yap John S Wu Rongling Functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimation BMC Plant Biology |
| title | Functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimation |
| title_full | Functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimation |
| title_fullStr | Functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimation |
| title_full_unstemmed | Functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimation |
| title_short | Functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimation |
| title_sort | functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimation |
| url | http://www.biomedcentral.com/1471-2229/11/23 |
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