Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study
Most obstetrical studies have focused on maternal response to the SARS-CoV-2 virus but much less is known about the effect of COVID-19 on fetal physiology. We aimed to evaluate the effect of the maternal SARS-CoV-2 infection on the fetal homeostasis with the use of detailed ultrasonography and echoc...
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MDPI AG
2023-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/16/5186 |
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| author | Iwona Strzelecka Oskar Sylwestrzak Julia Murlewska Jerzy Węgrzynowski Katarzyna Leszczyńska Krzysztof Preis Maria Respondek-Liberska |
| author_facet | Iwona Strzelecka Oskar Sylwestrzak Julia Murlewska Jerzy Węgrzynowski Katarzyna Leszczyńska Krzysztof Preis Maria Respondek-Liberska |
| author_sort | Iwona Strzelecka |
| collection | DOAJ |
| description | Most obstetrical studies have focused on maternal response to the SARS-CoV-2 virus but much less is known about the effect of COVID-19 on fetal physiology. We aimed to evaluate the effect of the maternal SARS-CoV-2 infection on the fetal homeostasis with the use of detailed ultrasonography and echocardiography and consideration of the effect of vaccination. This was a multi-center study of fetuses who had prenatal detailed ultrasound and echocardiographic examinations performed by fetal cardiology specialists. The subjects were divided based on the COVID vaccination status (vaccinated women who did not have COVID-group V, unvaccinated women who had COVID-group UV, and unvaccinated women who did not have COVID-control group). We evaluated the ultrasound and echocardiography results obtained. The study group included 237 gravidas from four prenatal cardiology centers. In the group of fetuses with normal heart anatomy, normal cardiovascular function had 147 (81%) fetuses and functional cardiovascular anomalies were present in 35 (19%) cases. Functional cardiovascular anomalies were present in 11 (16%) fetuses in the V group, 19 (47%) fetuses in the UV group and 5 (8%) fetuses in the control group (<i>p</i> < 0.01). There were 56 (24%) fetuses with extracardiac anomalies. Extracardiac anomalies were present in 20 (22%) fetuses in the V group, 22 (45%) fetuses of the UV group and in 14 (14%) fetuses in the control group (<i>p</i> < 0.01). Our study has proved that maternal COVID-19 infection can affect the fetal physiology and mild cardiac and extracardiac markers detected by fetal ultrasonography and echocardiography. Moreover, maternal vaccination results in lower occurrence of these findings in fetuses. |
| first_indexed | 2024-03-10T23:50:40Z |
| format | Article |
| id | doaj.art-98f61f25d92547708a56c492332988a0 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T23:50:40Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-98f61f25d92547708a56c492332988a02023-11-19T01:39:07ZengMDPI AGJournal of Clinical Medicine2077-03832023-08-011216518610.3390/jcm12165186Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort StudyIwona Strzelecka0Oskar Sylwestrzak1Julia Murlewska2Jerzy Węgrzynowski3Katarzyna Leszczyńska4Krzysztof Preis5Maria Respondek-Liberska6Department of Fetal Malformations Diagnosis and Prevention, Medical University of Łódź, 90-419 Lodz, PolandDepartment of Prenatal Cardiology, Polish Mother’s Memorial Hospital Research Institute in Łódź, 93-338 Lodz, PolandDepartment of Prenatal Cardiology, Polish Mother’s Memorial Hospital Research Institute in Łódź, 93-338 Lodz, PolandDepartment of Obstetrics and Gynecology, Zdroje Hospital, 70-780 Szczecin, PolandDepartment of Obstetrics, Medical University of Gdansk, 80-210 Gdansk, PolandDepartment of Obstetrics, Gynecological Diseases and Oncological Gynecology of the Regional Hospital in Toruń, 87-100 Toruń, PolandDepartment of Fetal Malformations Diagnosis and Prevention, Medical University of Łódź, 90-419 Lodz, PolandMost obstetrical studies have focused on maternal response to the SARS-CoV-2 virus but much less is known about the effect of COVID-19 on fetal physiology. We aimed to evaluate the effect of the maternal SARS-CoV-2 infection on the fetal homeostasis with the use of detailed ultrasonography and echocardiography and consideration of the effect of vaccination. This was a multi-center study of fetuses who had prenatal detailed ultrasound and echocardiographic examinations performed by fetal cardiology specialists. The subjects were divided based on the COVID vaccination status (vaccinated women who did not have COVID-group V, unvaccinated women who had COVID-group UV, and unvaccinated women who did not have COVID-control group). We evaluated the ultrasound and echocardiography results obtained. The study group included 237 gravidas from four prenatal cardiology centers. In the group of fetuses with normal heart anatomy, normal cardiovascular function had 147 (81%) fetuses and functional cardiovascular anomalies were present in 35 (19%) cases. Functional cardiovascular anomalies were present in 11 (16%) fetuses in the V group, 19 (47%) fetuses in the UV group and 5 (8%) fetuses in the control group (<i>p</i> < 0.01). There were 56 (24%) fetuses with extracardiac anomalies. Extracardiac anomalies were present in 20 (22%) fetuses in the V group, 22 (45%) fetuses of the UV group and in 14 (14%) fetuses in the control group (<i>p</i> < 0.01). Our study has proved that maternal COVID-19 infection can affect the fetal physiology and mild cardiac and extracardiac markers detected by fetal ultrasonography and echocardiography. Moreover, maternal vaccination results in lower occurrence of these findings in fetuses.https://www.mdpi.com/2077-0383/12/16/5186SARS-CoV-2COVIDfetal ultrasonographyfetal echocardiographyprenatal cardiology |
| spellingShingle | Iwona Strzelecka Oskar Sylwestrzak Julia Murlewska Jerzy Węgrzynowski Katarzyna Leszczyńska Krzysztof Preis Maria Respondek-Liberska Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study Journal of Clinical Medicine SARS-CoV-2 COVID fetal ultrasonography fetal echocardiography prenatal cardiology |
| title | Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study |
| title_full | Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study |
| title_fullStr | Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study |
| title_full_unstemmed | Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study |
| title_short | Fetal Cardiac Hemodynamic and Sonographic Anomalies in Maternal COVID-19 Infection Depending on Vaccination Status—Polish Multicenter Cohort Study |
| title_sort | fetal cardiac hemodynamic and sonographic anomalies in maternal covid 19 infection depending on vaccination status polish multicenter cohort study |
| topic | SARS-CoV-2 COVID fetal ultrasonography fetal echocardiography prenatal cardiology |
| url | https://www.mdpi.com/2077-0383/12/16/5186 |
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